Advanced Tailored Randomness: A Novel Approach for Improving the Efficacy of Biological Systems

Abstract

Improving the function of biological systems represents a significant task in the fight to control health conditions and slow down the aging process. Applying the laws of physics to a biological system is difficult, due to the multiple parameters that must be considered at the cellular and whole-organ levels. The second law of thermodynamics states that entropy, a measure of randomness in an isolated system, increases over time. Based on this concept, randomness has been suggested as a means by which the efficacy of isolated biological systems may be improved. While classical and quantum physics uses different definitions of randomness and complexity, biological randomness is as an essential component of the intrinsic unpredictability of life. The manifestation of biological randomness may be different for different individuals, leading to differences in patient outcomes. In this work, an approach for enhancing the effectiveness of biological systems based on a novel concept of advanced tailored randomness in patient care is presented.

Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects

“…Marked variability is a characteristic of many intracellular processes. 39 , 40 , 57 , 58 Drug-target interactions in the microenvironment of the cell do not always follow the rules of simple diffusion and chemical reactions. Multiple non-specific interactions of drugs with macromolecules in cells are not measured by simple pharmacodynamics methods.…”

“…A dynamic platform, based on signatures of patient-tailored variability, is being developed to ensure the long-term, sustainable beneficial effect of drugs, with minimal toxicity. 4 , 40 , 58 , 63 , 118 The platform is being developed in steps. In the first step, the effect of introducing variability into therapeutic regimens of patients who partially or completely lost their response to chronic medications is evaluated using algorithms that introduce pseudo-random number generators, which introduce variability in times of administration and dosages within an approved range.…”

Introducing variability in targeting the microtubules: Review of current mechanisms and future directions in colchicine therapy

“…Variability is inherent to biological systems and is considered a part of the normal function of cells and organs. [144][145][146] The dynamic instability of MTs exemplifies the variability in their structure and function. 147 Variability contributes to cell plasticity and is a method used for overcoming errors in the assembly and tasks at the cellular and potentially whole organ levels.…”

“…147 Variability contributes to cell plasticity and is a method used for overcoming errors in the assembly and tasks at the cellular and potentially whole organ levels. 145,145,146,[148][149][150] Variability also characterizes the response to certain therapies. 149 The introduction of variability was proposed as a method for overcoming partial or complete loss of effect to medications for chronic conditions.…”

Order Through Disorder: The Characteristic Variability of Systems

“…The term "randomness" is also being used when referring to the complexity of biological systems (Varella, 2018;El-Haj et al, 2019;Ilan, 2019b,c,d). In addition, this term can sometimes be used for describing noisy or stochastic behavior of systems, emphasizing some type of unpredictability of these structures (Trewavas, 2006;Tsimring, 2014;El-Haj et al, 2019;Ilan, 2020). Randomness also has some evolutionary implications, where variation and probability are linked with adaptation (Latta, 2008(Latta, , 2010.…”