Advanced Technologies for Gastrointestinal Endoscopy

Valdastri, Pietro; Simi, Massimiliano; Webster, Robert J.

doi:10.1146/annurev-bioeng-071811-150006

Cited by 182 publications

(122 citation statements)

References 128 publications

(128 reference statements)

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“…For drug release only, the disk batteries in the current endoscopic capsules (3V, 55mAh ≅ 20 mW) will be sufficient as they last 8-9 hours for powering a number of LEDs, taking images and sending them wirelessly to an external data recorder. A detailed review of endoscopic capsules is presented elsewhere [12,13,62,63,68].…”

Section: Expert Commentarymentioning

confidence: 99%

Towards soft robotic devices for site-specific drug delivery

Alici

2015

Expert Review of Medical Devices

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Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specific drug delivery (site-specific, controlled, targeted or smart drug delivery are terms used interchangeably in the literature, to mean to transport a drug or a therapeutic agent to a desired location within the body and release it as desired with negligibly small toxicity and side effect compared to classical drug administration means such as peroral, parenteral, transmucosal, topical and inhalation) based on mechanical/physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish soft robotic devices for clinical and biomedical applications. Towards soft robotic devices for site-specific drug delivery Abstract Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) which are mechanical / physical, chemical and biological/molecular DDS. In this paper, we report on recent advances in site-specific drug delivery 1 based on mechanical / physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish really soft robotic devices for clinical and biomedical applications.

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Section: Expert Commentarymentioning

confidence: 99%

Towards soft robotic devices for site-specific drug delivery

Alici

2015

Expert Review of Medical Devices

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“…Due to the limited capacity of battery, the recording time of VCE is about 8 to 11 hours, which is shorter than the digestion period of human body, so a part of gastrointestinal (GI) tract cannot be inspected. Meanwhile, the image capture rate is 2 to 8 frames per second and the resolution is 256×256, which would possibly miss the lesion areas [2][3][4]. The efficacy of playback functions were compared to reduce the reading time, a high-speed and high-efficiency system was developed, yet none of them reduced the power consumption nor extend the working time of VCE [5,6].…”

Section: Introductionmentioning

confidence: 99%

A portable wireless power transmission system for video capsule endoscopes

Yan

Zhu

et al. 2015

BME

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Abstract. Wireless power transmission (WPT) technology can solve the energy shortage problem of the video capsule endoscope (VCE) powered by button batteries, but the fixed platform limited its clinical application. This paper presents a portable WPT system for VCE. Besides portability, power transfer efficiency and stability are considered as the main indexes of optimization design of the system, which consists of the transmitting coil structure, portable control box, operating frequency, magnetic core and winding of receiving coil. Upon the above principles, the correlation parameters are measured, compared and chosen. Finally, through experiments on the platform, the methods are tested and evaluated. In the gastrointestinal tract of small pig, the VCE is supplied with sufficient energy by the WPT system, and the energy conversion efficiency is 2.8%. The video obtained is clear with a resolution of 320×240 and a frame rate of 30 frames per second. The experiments verify the feasibility of design scheme, and further improvement direction is discussed.

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“…Specific wireless capsule endoscopes have been proposed for colon inspection, but have not reached the diagnostic accuracy of standard colonoscopy (Eliakim et al 2009, Spada et al 2012. One of the main limitations of commercially available capsule endoscopes is passive locomotion (Valdastri, Simi & Webster III 2012). It is desirable for the endoscopist to be able to maneuver the camera arbitrarily rather than relying on peristalsis to drive the capsule for adequate visualization of GI mucosa.…”

Section: Introductionmentioning

confidence: 99%

A wireless platform forin vivomeasurement of resistance properties of the gastrointestinal tract

et al. 2014

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Abstract. Active locomotion of wireless capsule endoscopes has the potential improve the diagnostic yield of this painless technique for the diagnosis of gastrointestinal tract disease. In order to design effective locomotion mechanisms, a quantitative measure of the propelling force required to effectively move a capsule inside the gastrointestinal tract is necessary.In this study, we introduce a novel wireless platform that is able to measure the force opposing capsule motion, without perturbing the physiologic conditions with physical connections to the outside of the gastrointestinal tract. The platform takes advantage of a wireless capsule that is magnetically coupled with an external permanent magnet. A secondary contribution of this manuscript is to present a real-time method to estimate the axial magnetic force acting on a wireless capsule manipulated by an external magnetic field. In addition to the intermagnetic force, the platform provides real-time measurements of the capsule position, velocity, and acceleration.The platform was assessed with benchtop trials within a workspace that extends 15 cm from each side of the external permanent magnet, showing average error in estimating the force and the position of less than 0.1 N and 10 mm, respectively. The platform was also able to estimate the dynamic behavior of a known resistant force with an error of 5.45%. Finally, an in vivo experiment on a porcine colon model validated the feasibility of measuring the resistant force in opposition to magnetic propulsion of a wireless capsule.

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Advanced Technologies for Gastrointestinal Endoscopy

Cited by 182 publications

References 128 publications

Towards soft robotic devices for site-specific drug delivery

Towards soft robotic devices for site-specific drug delivery

A portable wireless power transmission system for video capsule endoscopes

A wireless platform forin vivomeasurement of resistance properties of the gastrointestinal tract

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