Advancements in Bioengineered Corneas for Vision Restoration -A Systematic Review

Abstract

The quest for vision restoration has witnessed significant advancements in the field of bioengineering, particularly in the development of bioengineered corneas. The cornea, as a critical component of the visual system, plays an essential role in light refraction and focusing, directly impacting visual acuity. In recent years, bioengineered corneas have emerged as a promising solution for patients suffering from corneal blindness due to injury, disease, or congenital defects.The review presented herein aims to comprehensively analyze and evaluate the latest advancements in bioengineered corneas for vision restoration. Through an extensive search of academic databases and scientific literature, relevant studies and research articles were identified and selected for inclusion in this review. The selected studies cover a diverse range of approaches and methodologies, including tissue engineering, cell-based therapies, 3D bioprinting, and regenerative medicine techniques.Additionally, this review critically assesses the outcomes of preclinical and clinical studies involving bioengineered corneas, shedding light on the safety, efficacy, and long-term viability of these innovative approaches. Ethical considerations, regulatory hurdles, and potential challenges in large-scale implementation are also addressed.The findings of this systematic review highlight the tremendous potential of bioengineered corneas in restoring vision for corneal blindness patients. While acknowledging the progress made thus far, it also identifies areas for further research and refinement. The pursuit of effective and accessible bioengineered corneal solutions stands to transform the field of ophthalmology, offering renewed hope for those afflicted with corneal blindness and paving the way for a brighter future in vision restoration.