2024
DOI: 10.1021/acssynbio.4c00599
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Advancements in Microbial Cell Engineering for Benzylisoquinoline Alkaloid Production

Liyan Cao,
Desmond Teo,
Yuyang Wang
et al.

Abstract: Benzylisoquinoline alkaloids (BIAs) are a class of natural compounds found in plants of the Ranunculaceae family, known for their diverse pharmacological activities. However, the extraction yields of BIAs from plants are limited, and the cost of chemical synthesis is prohibitively high. Recent advancements in systems metabolic engineering and genomics have made it feasible to use microbes as bioreactors for BIAs production. This review explores recent progress in enhancing the production and yields of BIAs in … Show more

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