Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology

Baral, Kshitis Chandra; Bajracharya, Rajiv; Lee, Sang Hoon; Han, Hyo-Kyung

doi:10.2147/ijn.s337427

Cited by 72 publications

(49 citation statements)

References 157 publications

(252 reference statements)

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“…; and (4) yeast bacteria . Studies have shown that probiotic preparations combined with antibiotics can effectively relieve the clinical symptoms of patients with H. pylori infection, improve the effect of H. pylori eradication and reduce the incidence of adverse drug reactions ( Baral et al., 2021 ) ( Figure 3 ). Commonly used probiotic preparations in the clinic include L. acidophilus, Bacillus licheniformis, Bifidobacterium triple viable bacteria , Bacillus subtilis dual viable bacteria and Saccharomyces boulardii ( Lu et al., 2022 ).…”

Section: Effect Of Intestinal Probiotics On H Pylori ...mentioning

confidence: 99%

Relationship between Helicobacter pylori infection and gastrointestinal microecology

2022

Front. Cell. Infect. Microbiol.

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The prevalence of Helicobacter pylori (H. pylori) infection has exceeded 50% worldwide, and it is considered a high-risk factor for chronic gastritis, peptic ulcer, gastric adenocarcinoma, gastroesophageal reflux disease and functional dyspepsia. H. pylori drug resistance is a common problem worldwide. In recent years, the relationship between H. pylori infection and gastrointestinal microecology has received much attention. H. pylori infection changes the structure and composition of gastrointestinal microflora by regulating the gastrointestinal microecological environment, local pH value, cytokines and antimicrobial peptides, and immune response and then plays a crucial role in the occurrence and development of digestive system tumors, liver metabolism and extragastrointestinal diseases. The quadruple strategy of H. pylori eradication can also aggravate gastrointestinal microflora disorder. However, probiotics can reduce intestinal flora changes and imbalances through different mechanisms, thus enhancing the efficacy of H. pylori eradication therapy and reducing adverse reactions caused by eradication therapy. Therefore, this paper reviews the relationship between H. pylori infection and gastrointestinal microecology and its clinical application, providing a basis for clinical treatment.

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Section: Effect Of Intestinal Probiotics On H Pylori ...mentioning

confidence: 99%

Relationship between Helicobacter pylori infection and gastrointestinal microecology

2022

Front. Cell. Infect. Microbiol.

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“…For instance, potential factors that may hamper the airway delivery of probiotics are rapid mucociliary clearance, short retention time, enzymatic degradation, low stability in mucus and competition with lung indigenous or pathogenic microflora. Nasal delivery of probiotics via nasal spray seems a promising and feasible administration approach that has demonstrated its efficacy in animal models and clinical studies [82], but other ways of delivery (e.g., aerosol) that ensure a high volume and efficient arrival of therapeutic bacteria to the lower respiratory tract are worth being explored.…”

Section: Mode Of Administration and Formulationmentioning

confidence: 99%

“…Modern formulation technologies and biomaterials are being intensively investigated and hold promise for providing optimized production processes and sophisticated de-livery systems with the controlled release of probiotics for site-specific applications in the years to come [81,82]. Specifically, some nanomaterial-based formulations including nanofibers, nanoparticles and nanocomposites seem to meet most of the requirements for delivery systems of probiotics including efficient encapsulation, controlled release and improved stability of the therapeutic bacteria during manufacturing, storage and in vivo applications [82]. For instance, in a recent study, Jokicevic and coworkers analyzed several spray-dried formulations for probiotic nasal delivery [83].…”

Section: Mode Of Administration and Formulationmentioning

confidence: 99%

Lung-Directed Bacteriotherapy in Cystic Fibrosis: Could It Be an Option?

et al. 2022

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Due to the alarming spread of bacterial resistance to conventional drugs, the sole use of antibiotics to fight lung infections in cystic fibrosis (CF) is not resolutive, and novel strategies to replace or complement the use of antibiotics are highly desirable. Among these strategies, the use of probiotics is emerging as a particularly attractive approach. Probiotic administration via the oral route has demonstrated an ability to improve lung function and to reduce infection and exacerbation rates in CF patients through mechanisms mainly attributable to the gut–lung axis. Nevertheless, some studies reported no beneficial effect of probiotic intake suggesting that there is margin for improvement of such innovative intervention in CF. The present review aims to address the rationale behind probiotic use in CF and discuss the hypothesis that nasal/aerosol administration of appropriate probiotic strains may help to exert a direct beneficial effect on the respiratory tract, increasing the effectiveness of probiotic interventions in CF patients.

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“…Moreover, probiotics viability may be decreased under thermal conditions during their preparation or shelf life. Therefore, formulations of probiotics should consider the various physicochemical, biopharmaceutical, and biological barriers to make the best of their therapeutic effectiveness and clinical applicability ( Baral et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Layer-by-Layer Coating of Single-Cell Lacticaseibacillus rhamnosus to Increase Viability Under Simulated Gastrointestinal Conditions and Use in Film Formation

et al. 2022

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Probiotics and prebiotics are widely used as functional food ingredients. Viability of probiotics in the food matrix and further in the digestive system is still a challenge for the food industry. Different approaches were used to enhance the viability of probiotics including microencapsulation and layer-by-layer cell coating. The of aim of this study was to evaluate the viability of coated Lacticaseibacillus rhamnosus using a layer-by-layer (LbL) technique with black seed protein (BSP) extracted from Nigella sativa defatted seeds cakes (NsDSC), as a coating material, with alginate, inulin, or glucomannan, separately, and the final number of coating layers was 3. The viable cell counts of the plain and coated L. rhamnosus were determined under sequential simulated gastric fluid (SGF) for 120 min and simulated intestinal fluid (SIF) for 180 min. Additionally, the viability after exposure to 37, 45, and 55°C for 30 min was also determined. Generally, the survivability of coated L. rhamnosus showed significant (p ≤ 0.05) improvement (<4, 3, and 1.5 logs reduction for glucomannan, alginate and inulin, respectively) compared with plain cells (∼6.7 log reduction) under sequential exposure to SGF and SIF. Moreover, the cells coated with BSP and inulin showed the best protection for L. rhamnosus under high temperatures. Edible films prepared with pectin with LbL-coated cells showed significantly higher values in their tensile strength (TS) of 50% and elongation at the break (EB) of 32.5% than pectin without LbL-coated cells. The LbL technique showed a significant protection of probiotic cells and potential use in food application.

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Advancements in the Pharmaceutical Applications of Probiotics: Dosage Forms and Formulation Technology

Cited by 72 publications

References 157 publications

Relationship between Helicobacter pylori infection and gastrointestinal microecology

Relationship between Helicobacter pylori infection and gastrointestinal microecology

Lung-Directed Bacteriotherapy in Cystic Fibrosis: Could It Be an Option?

Layer-by-Layer Coating of Single-Cell Lacticaseibacillus rhamnosus to Increase Viability Under Simulated Gastrointestinal Conditions and Use in Film Formation

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