Advances and Current Clinical Applications of Anterior Segment Optical Coherence Tomography Angiography

Luo, Man; Li, Yiqing; Zhuo, Yehong

doi:10.3389/fmed.2021.721442

Cited by 6 publications

(6 citation statements)

References 86 publications

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“…The main drawback of switching scan configurations is the time gap for changing the settings. Recently, Luo et al have demonstrated an SS-OCT prototype that utilizes a single source and a single detection channel for sequential imaging ( 192 ).…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

et al. 2022

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The field of ophthalmic imaging has grown substantially over the last years. Massive improvements in image processing and computer hardware have allowed the emergence of multiple imaging techniques of the eye that can transform patient care. The purpose of this review is to describe the most recent advances in eye imaging and explain how new technologies and imaging methods can be utilized in a clinical setting. The introduction of optical coherence tomography (OCT) was a revolution in eye imaging and has since become the standard of care for a plethora of conditions. Its most recent iterations, OCT angiography, and visible light OCT, as well as imaging modalities, such as fluorescent lifetime imaging ophthalmoscopy, would allow a more thorough evaluation of patients and provide additional information on disease processes. Toward that goal, the application of adaptive optics (AO) and full-field scanning to a variety of eye imaging techniques has further allowed the histologic study of single cells in the retina and anterior segment. Toward the goal of remote eye care and more accessible eye imaging, methods such as handheld OCT devices and imaging through smartphones, have emerged. Finally, incorporating artificial intelligence (AI) in eye images has the potential to become a new milestone for eye imaging while also contributing in social aspects of eye care.

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Section: Optical Coherence Tomographymentioning

confidence: 99%

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

et al. 2022

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“…The major drawback of OCTA when compared to the traditional angiography tools lies in its inability to identify the flow characteristics and thus, patterns of leakage, the difference between afferent and efferent systems, etc. cannot be captured with OCTA [30,31]. In the context of ocular burns, this is relevant as images from OCTA may not distinguish vasospasm from true ischemia and thus caution must be exercised during interpretation of OCTA scans.…”

Section: Comparison With Fluorescein Angiography (Fa) and Indocyanine...mentioning

confidence: 99%

“…The OCT machines are devised to image the structure and functional blood flow of the retina and the choroid. To do so, a special adaptor lens attachment is usually required to perform anterior segment angiography; however, the image acquisition can also be carried out by manually adjusting the focus [31,34]. In such cases, the external lens is very close to the patient's eye and care has to be taken to avoid accidental trauma [3].…”

Section: Image Acquisitionmentioning

confidence: 99%

Role of Anterior Segment-Optical Coherence Tomography Angiography in Acute Ocular Burns

Kate

Basu

2022

Diagnostics

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Acute ocular burns have varied manifestations which require prompt diagnosis and management to prevent chronic sequelae. Of these, the detection of limbal ischemia poses a challenge because of the subjective nature of its clinical signs. Anterior segment optical coherence tomography angiography (AS-OCTA) offers an objective method of assessing ischemia in these eyes. This review provides an overview of the technology of AS-OCTA and its applications in acute burns. AS-OCTA generates images by isolating the movement of erythrocytes within blood vessels from sequentially obtained b-scans. Limbal ischemia manifests in these scans as absent vasculature and the extent of ischemia can be quantified using different vessel-related parameters. Of these, the density of vessels is most commonly used and correlates with the severity of the injury. Incorporation of the degree of ischemia in the classification of acute burns has been attempted in animal studies and its extension to human trials may provide an added dimension in determining the final prognosis of these eyes. Thus, AS-OCTA is a promising device that can objectively evaluate limbal ischemia. This will facilitate the identification of patients who will benefit from revascularization therapies and stem cell transplants in acute and chronic ocular burns, respectively.

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“… 16 , 17 In recent years, anterior segment OCTA (AS-OCTA) has gained acceptance, and its value has been validated in various anterior segment diseases, including glaucoma filtering surgery (GFS) and minimally invasive glaucoma surgery (MIGS). 18 – 25 Previous studies found that superficial vascular density (SVD) in the bleb area was more associated with postoperative IOP and surgical outcome than IBAGS and MBGS. 22 , 26 , 27 However, none of them have provided a joint analysis of the vascular and morphological parameters.…”

Section: Introductionmentioning

confidence: 99%

Multi-Quantitative Assessment of AS-OCTA Complemented AS-OCT for Monitoring Filtering Bleb Function After Trabeculectomy

Luo

Xiao

Huang

et al. 2023

Trans. Vis. Sci. Tech.

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Purpose The purpose of this study was to explore a quantitative grading system of the filtering bleb combined anterior segment optical coherence tomography angiography (AS-OCTA) vascular features and optical coherence tomography (OCT) morphological features. Methods One hundred three eyes of 103 patients diagnosed with primary open-angle glaucoma and undergone trabeculectomy over 6 months were divided into success and failure groups according to postoperative intraocular pressure (IOP) level. Vessel density (VD) and vessel diameter index (VDI) were examined by AS-OCTA. Bleb's morphology, including bleb height (BH), and microcyst-structure (MCS) were detected by AS-OCT. Multi-vascular model score (MVMS) was calculated by comprehensive factor analysis, and the comprehensive grading system (MVMS-MCS-BH) was analyzed by linear regression. The efficiency our method was verified by receiver operating characteristic (ROC) analysis. Results The VD and VDI were higher in the failure group and closely related to post-trabeculectomy IOP (all P = 0.000). The MVMS was mostly consisted of VD in all regions, and VDIs of nasal, central, and temporal positions in sequence. MVMS ≥0, BH <1.33, and non-MCS were significantly associated with IOP increasing (coefficient = –3.23, –3.69, and 8.10, all P = 0.000). MVMS-BH-MCS got a higher area under curve (AUC), sensitivity, and specificity (0.92, 100%, and 80.30%) than the slit-lamp method (0.62, 72.20%, and 46.43%, respectively). Conclusions The quantitative vascular characteristics detected by AS-OCTA were significant for the bleb monitor. The MVMS-BH-MCS grading system had achieved outstanding accuracy in reflecting the surgical results. Translational Relevance The multi-vascular biomarker and comprehensive evaluation combined vascular and morphological parameters yield useful information on surgical outcomes, and help ophthalmologists to monitor patients effectively.

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Advances and Current Clinical Applications of Anterior Segment Optical Coherence Tomography Angiography

Cited by 6 publications

References 86 publications

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

Role of Anterior Segment-Optical Coherence Tomography Angiography in Acute Ocular Burns

Multi-Quantitative Assessment of AS-OCTA Complemented AS-OCT for Monitoring Filtering Bleb Function After Trabeculectomy

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