Advances and novel developments in molecular allergology

Abstract

New technologies are changing the way research is performed in many areas of molecular allergology. 1 Recombinant (r) allergens have influenced the development of allergy diagnosis and allergen-specific immunotherapy (AIT) for over three decades. 2 Although the gold rush of allergen discovery is over, gaps in our knowledge of structures, cross-reactivities, and conformational epitopes are being constantly filled. 2,3

Peanut components measured by ISAC: comparison with ImmunoCap and clinical relevance in peanut allergic children

“…Both skin prick test and serum sIgE to whole peanut extract have a high sensitivity but poor specificity in identifying peanut allergic patients [ 8 , 9 ]. The development of component-resolved diagnostics (CRD) has enabled a diagnostic approach of peanut allergy at protein (component) level [ 10 , 11 ]. With the measurement of sIgE to the individual peanut proteins, sensitization to peanut major allergens and cross-reactive peanut allergens can be distinguished.…”

“…With the measurement of sIgE to the individual peanut proteins, sensitization to peanut major allergens and cross-reactive peanut allergens can be distinguished. Component resolved diagnostics may help clinicians in their diagnostic approach, for example to prevent unnecessary food challenges and to assess the risk of a clinically relevant peanut allergy [ 11 , 12 ].…”

Real word evidence studies: Is it the way forward?

“…The importance of CRD in allergy diagnosis and AIT has slowly been unravelled, with the concept being accepted by World Allergy Organisation (WAO). Studies to investigate diagnostic approaches for component testing have therefore been of huge interest 7 . In a systematic review published within the current issue by Maesa et al, 8 the diagnostic accuracy of component testing within the ImmunoCAP ISAC panel was thoroughly investigated.…”

“…Studies to investigate diagnostic approaches for component testing have therefore been of huge interest. 7 In a systematic review published within the current issue by Maesa et al, 8 various studies highlighted that diagnostic test accuracy information for ISAC components is highly specific but not very sensitive, in contrast to other diagnostics for food allergy such as skin prick test and specific IgE to whole allergens, where sensitivity tends to be high but false positive readings are very common. With this thorough systematic review, we can gather that there is a lack of evidence for most components and the quality of evidence analysed is insufficient to confirm that ImmunoCAP ISAC can be used as a diagnostic test in place of the gold standard approach Component testing may, however, provide useful additional information above standard allergy tests, taking into consideration the lower sensitivity and higher specificity than other forms of allergy testing.…”

Sağlık Mesleği Mensuplarının Suçu Bildirmemesi Suçu (TCK m. 280)

“…Sağlık mesleği mensubunun "görevini yaptığı sırada" ifadesi sağlık mesleği mensubunun mesleğini icra ettiği anı ifade ettiğinden, bu suç sadece sağlık kuruluşlarında karşılaşılan suçları değil, sağlık mesleği mensubunun yer ve zaman fark etmeksizin tıbbi bir hizmet sunduğu sırada karşılaştığı tüm suçları kapsamaktadır 51 . Sözgelimi bir hekimin hastasını muayene etmek için gittiği evde bir suç işlendiğine yönelik belirtiyle karşılaşması durumunda da bildirim yükümlülüğü doğmakta, bildirimde bulunulmaması durumunda ise sağlık mesleği mensuplarının suçu bildirmemesi suçu oluşmaktadır 52 .…”