Advances in analytical techniques and quality control of traditional Chinese medicine injections

Tu, Yujia; Li, Linnan; Wang, Zhengtao; Yang, Li

doi:10.1016/j.jpba.2021.114353

Cited by 23 publications

(22 citation statements)

References 72 publications

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“… 30 Compared with injections, paeonol tablets, ointments and patches have low bioavailability, but injections contain high concentrations of tween 80 and ethanol to stimulate blood vessels and muscles. 31 Modern research has used nanotechnology, 32 , 33 cyclodextrin inclusion, 20 and derivatization technology to modify it. 34 Although these preparation techniques have improved the problem of low bioavailability of paeonol, there is a lack of relevant pharmacodynamic experiments to verify the anti-inflammatory effects of their preparations.…”

Section: Discussionmentioning

confidence: 99%

Development of Paeonol Liposomes: Design, Optimization, in vitro and in vivo Evaluation

Huang¹,

Zhai²,

Yang³

et al. 2022

IJN

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Background Ulcerative colitis (UC) is one of the intractable diseases recognized by the World Health Organization, and paeonol has been proven to have therapeutic effects. However, the low solubility of paeonol limits its clinical application. To prepare and optimize paeonol liposome, study its absorption mechanism and the anti-inflammatory activity in vitro and in vivo, in order to provide experimental basis for the further development of paeonol into an anti-inflammatory drug in the future. Methods Paeonol loaded liposomes were prepared and optimized by thin film dispersion-ultrasonic method. The absorption mechanism of paeonol-loaded liposomes was studied by pharmacokinetics, in situ single-pass intestinal perfusion and Caco-2 cell monolayer model, the anti-inflammatory activity was studied in a mouse ulcerative model. Results Box-Behnken response surface methodology permits to screen the best formulations. The structural and morphological characterization showed that paeonol was entrapped inside the bilayer in liposomes. Pharmacokinetic studies found that the AUC 0-t of Pae-Lips was 2.78 times than that of paeonol suspension, indicating that Pae-Lips significantly improved the absorption of paeonol. In situ single intestinal perfusion and Caco-2 monolayer cell model results showed that paeonol was passively transported and absorbed, and was the substrate of P-gp, MRP2 and BCRP, and the Papp value of Pae-Lips was significantly higher than that of paeonol. In vitro and in vivo anti-inflammatory experiments showed that compared with paeonol, Pae-Lips exhibited excellent anti-inflammatory activity. Conclusion In this study, Pae-Lips were successfully prepared to improve the oral absorption of paeonol. Absorption may involve passive diffusion and efflux transporters. Moreover, Pae-Lips have excellent anti-inflammatory activity in vitro and in vivo, which preliminarily clarifies the feasibility of further development of Pae-Lips into oral anti-inflammatory drugs.

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Section: Discussionmentioning

confidence: 99%

Development of Paeonol Liposomes: Design, Optimization, in vitro and in vivo Evaluation

Huang¹,

Zhai²,

Yang³

et al. 2022

IJN

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“…The peak at 8.11 ppm was selected as IS peak, and the peaks at 1.68 and 0.79 ppm were selected as quantitative peaks of TG. The molarity of TG was calculated according to Equation (2).…”

Section: Quantificationmentioning

confidence: 99%

“…Compound herbal injections (CHIs), as a significant innovation in the modernisation of herbal medicine, are extensively known for their rapid curative effect and high bioavailability 1 . CHIs are widely used to treat various diseases including cancer, musculoskeletal disorders, cardiovascular and cerebrovascular dysfunction, and bacterial and viral infections, 2 which are also of particular value against the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) 3 . CHIs are usually prepared from the extracts of multiple herbal medicines, thus containing more complex chemical components.…”

Section: Introductionmentioning

confidence: 99%

Quantitative profiling of comprehensive composition in compound herbal injections: An NMR approach applied on Shenmai injection

Zhao

Xie

et al. 2022

Phytochemical Analysis

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Introduction: Compound herbal injections (CHIs) can be regarded as a significant innovation in the modernisation of herbal medicine. Therefore, improving the quality control level of CHIs has always been an active research topic in traditional herbal medicine.Objectives: In this study, Shenmai injection was used as a representative sample for investigating the ability of proton nuclear magnetic resonance ( 1 H NMR) in the quality evaluation of CHIs.Methods: A quantitative 1 H NMR method was developed to simultaneously determine the contents of total ginsenosides, polysorbate 80, and 20 primary metabolites in Shenmai injection. Multivariate statistical analysis was combined to compare differences between samples from different manufacturers.Results: It was found that the combined measurement uncertainty of each component is less than 1.61%, which demonstrates the reliability of the method. Furthermore, the components determined by this method account for up to 92.64% of the total solids, which is an unprecedented success in the analysis of Shenmai injection.In the end, the method was applied to the quality comparison of Shenmai injection from six manufacturers. The results showed that the differences among the samples from the six manufacturers were reflected in multiple types of components. Conclusion:This study fully demonstrates the superiority of the quantitative 1 H NMR method in comprehensive composition profiling of CHIs, which is conducive to improving the quality control level of Shenmai injection. Further, the present study can be used as a reference study for the research on the quality and safety of CHIs.

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“…Traditional Chinese medicines (TCMs) exhibit a diverse array of pharmacological activities and have recently been found to represent promising drug precursors with unique chemical structures, many of which might be used as natural anti-inammatory reagents. 1,2 Inammation is an immunemediated response to trauma induced by physical, chemical, or pathogenic stimuli. 3 Unrestrained or inappropriate inammation, however, can contribute to the incidence of a range of diseases such as hypertension, obesity, and diabetes.…”

Section: Introductionmentioning

confidence: 99%

Preparative isolation of maltol glycoside from Dianthus superbus and its anti-inflammatory activity in vitro

et al. 2022

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Advances in analytical techniques and quality control of traditional Chinese medicine injections

Cited by 23 publications

References 72 publications

Development of Paeonol Liposomes: Design, Optimization, in vitro and in vivo Evaluation

Development of Paeonol Liposomes: Design, Optimization, in vitro and in vivo Evaluation

Quantitative profiling of comprehensive composition in compound herbal injections: An NMR approach applied on Shenmai injection

Preparative isolation of maltol glycoside from Dianthus superbus and its anti-inflammatory activity in vitro

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