This special issue of The Anatomical Record honors the bridges of knowledge and communications between Brazil and the United States in Anatomical Science, Healthcare, and Medical Education. The volume is organized in two sets of manuscripts: the first one stems from presentations of Brazilian colleagues in the latest iteration of the Building Bridges outreach initiative-a meeting entitled Building Bridges Back to Back, held at the Icahn School of Medicine at Mount Sinai, in December of 2019; the second, is a compilation of selected papers submitted independently to The Anatomical Record, authored by Brazilian researchers. All abstracts in this volume are featured in English and in Portuguese, and the opening piece is fully available in both languages. This bold and innovative addition represents the commitment of The Anatomical Record to support and help grow our bridges; it is a gesture of utmost respect and appreciation for our people and our culture. Together, our efforts to advance the knowledge in basic, translational, and clinical sciences, to expand our connections, and to build on our relationships across boundaries becomes a reality. This is an introduction and an overview of the manuscripts contained in this very special issue.