Advances in Biomarkers and Diagnostics in Periodontitis and Oral Diseases

Isola, Gaetano

doi:10.3390/ijerph18041886

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…In the future, studies with a larger sample size are needed to validate these findings. Biomarkers have been implicated in inflammation and nutrition [ 6 ]. The bacterial origin of inflammation begins with a biofilm-bacterial imbalance, which leads to the regulation of inflammatory cytokines and ultimately determines the sprouting of oxidative stress cells [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with a reduced food intake after third molar extraction among adults: a cross-sectional study

et al. 2022

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Background Functional impairment after third molar extraction may decrease the food intake. Elucidation of associated factors will contribute to a more appropriate postoperative nutritional management, and was the aim of the present study. Methods Adults aged < 60 years who were admitted for an extraction of one or more mandibular third molars were included. Those with diabetes mellitus, anemia, metabolic diseases, mental retardation, altered dietary intake, and postoperative paralysis of the lower lip and tongue were excluded. Patient-specific risk factors were compared in relation to a decrease in the food intake on postoperative day 1. Multivariate analysis took into account the patients’ background factors. Results A total of 254 patients were included (median age: 26.8 ± 9.3 years, 142 women); 508 third molars were extracted. Postoperative dietary intake reduction was more common (p < 0.05) after an exclusively mandibular extraction (16.0%) than after an extraction including the maxilla (29.4%). The reduction was also more common (p < 0.05) for an extraction difficulty of Pell–Gregory class III (39.5%) than for extraction difficulties of Pell–Gregory classes I (22.6%) and II (21.3%). The reduction was also more common (p < 0.05) in patients who experienced postoperative pain (66.7%) than in those who did not (23.3%). Significant differences were observed in sex (women: 34.5%, men: 11.6%) and age (young patients [< 26 years]: 31.1%, adult patients [≥ 26 years]: 17.2%); however, no significant difference was found in terms of experiencing trismus (p < 0.11). Simple regression analysis showed significant differences between patients who did and did not have a reduced postoperative food intake depending on the sex, age, extraction site, degree of extraction difficulty, trismus, and postoperative pain. Reduced dietary intake was significantly associated with sex (odds ratio [OR]: 0.30; 95% confidence interval [CI]: 0.14–0.38), age (OR: 1.6; 95% CI: 1.0–2.5), extraction site (OR: 0.51; 95% CI: 0.31–0.83), difficulty of extraction (OR: 0.66; 95% CI: 0.50–0.88), and postoperative pain (OR: 0.12; 95% CI: 0.04–0.37). Conclusions A younger age, female sex, extraction including the maxilla with deep implantation, and complaints of pain on postoperative day 1 were factors associated with a decreased food intake after third molar extraction.

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Section: Discussionmentioning

confidence: 99%

“…These discomforts affect chewing and swallowing functions and may reduce the postoperative food intake; this is of great concern in these patients. Several factors, including biomarkers [ 6 ], are involved in decreased postoperative food intake. For instance, chemotherapy causes oral mucositis.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with a reduced food intake after third molar extraction among adults: a cross-sectional study

et al. 2022

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“…Although it is effective on the amount of saliva, risk of caries and caries activity, reduced saliva flow rate adversely affects oral health. 23 Several studies on saliva functions report that stimulated saliva is used more advantageously than unstimulated saliva. This is because the stimulated saliva sample is more resistant to daily pH changes.…”

Section: Discussionmentioning

confidence: 99%

Assessment of DMFT Indexes, Salivary Flow Rate, Ph, and Detections of S.MUTANS Salivary Levels by a Quantitative Real-Time PCR in Polycystic Ovary Syndrome

HİLALOĞLU¹,

Sürmelioğlu

2022

Cumhuriyet Dental Journal

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Objectives: PCOS is an endocrine disorder that is common in women. However, PCOS effects on oral and dental health have not been stated clearly. The aim of this study is to examine the effects of Polycystic Ovary Syndrome (PCOS), which is common in women of reproductive age, on saliva and dental tissues in these women. Materials and Methods: One-hundred individuals who were / were not diagnosed with PCOS and insulin resistance were included in this study (n=100). Subsequently, individuals, with PCOS and insulin resistance (PCOSID +), with PCOS and non-insulin resistance (PCOSID-), without PCOS and insulin resistance (ControlID +) and without PCOS and non-insulin resistance (ControlID-) were divided into 4 groups (n=25). DMFT (Decayed, Missing, Filled Teeth) index was used for dental health evaluation, while pH meter was used for saliva pH measurement. Also, Streptococcus Mutans (S. Mutans) numbers were analyzed by the real-time Polymerase Chain Reaction (PCR) method. In statistical analysis p

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“…There were numerous studies on other possible polymorphisms, such as Fcγ, interferon γ and IL-13, connected with periodontal symptoms (Chai et al 2012 ; Shi et al 2017 ; Wang et al 2017 ; Zhang et al 2018a ). A search for potential markers of periodontitis onset or progression resulted in many potential candidates for such agent—among others matrix metalloproteinase (MMP)-8, IL-1, IL-6, tumor necrosis factor (TNF)-α, PGE 2 (Barros et al 2016 ; Chen et al 2019 ; He et al 2018 ; Isola 2021 ). The goal was to be able to quickly and efficiently screen the population to reach individuals requiring more frequent and thorough prophylactic actions, on the other hand reducing clinical efforts put on the rest of the population, not needing so frequent meetings with periodontists or hygienists.…”

Section: Markers Of the Diseasementioning

confidence: 99%

What Has Immunology Brought to Periodontal Disease in Recent Years?

Kowalski

Nowak

Górski

et al. 2022

Arch. Immunol. Ther. Exp.

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Recent decades have shed a new light on the pathomechanism of periodontal inflammation. While classic periodontology concentrates on biofilm control, oral hygiene improvement, professional tooth cleaning and surgical correction of damaged periodontal tissues, new aspects of the destruction mechanisms are being raised. Among them, the greatest attention is paid to the influence of host response on the clinical manifestations of the disease. Numerous studies have proved that the shift from gingivitis to periodontitis is not a simple progress of the disease, but an event occurring only in susceptible individuals. Susceptibility may result from appearance of local factors facilitating biofilm accumulation and/or maturation, or from systemic features, among which over-reaction and prolonged agitation of non-specific component of inflammatory response is crucial. The present paper summarizes the association between periodontology and immunology and updates the knowledge accrued mostly in the recent years. After a brief explanation of advances in understanding of the disease aetiology, the most studied and potentially viable immunological markers of periodontal disease are presented. Possible new therapeutic strategies, exploiting knowledge about the nature of host response—immunomodulation and reduction of chronic oxidative stress—are also presented.

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Advances in Biomarkers and Diagnostics in Periodontitis and Oral Diseases

Abstract: Oral health is essential to general health and well-being at every stage of life [...]

Cited by 10 publications

References 24 publications

Factors associated with a reduced food intake after third molar extraction among adults: a cross-sectional study

Factors associated with a reduced food intake after third molar extraction among adults: a cross-sectional study

Assessment of DMFT Indexes, Salivary Flow Rate, Ph, and Detections of S.MUTANS Salivary Levels by a Quantitative Real-Time PCR in Polycystic Ovary Syndrome

What Has Immunology Brought to Periodontal Disease in Recent Years?

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