Advances in cell-laden hydrogels for delivering therapeutics

Orive, Gorka; Echave, Mari Carmen; Pedraz, José Luís; Golafshan, Nasim; Dolatshahi-Pirouz, Alireza; Paolone, Giovanna; Emerich, Dwaine F.

doi:10.1080/14712598.2019.1654452

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…These studies demonstrated long-term and stable bioactive/efficacious effects on the nigrostriatal dopaminergic system. As such, this delivery system represents a novel version of previous encapsulated cell-based systems to deliver trophic factors to the brain and may be developed into a disease modifying and effective treatment for PD and other diseases ( Saito et al., 2017 , Tornøe et al., 2012 , Falcicchia et al., 2018 , Emerich et al., 2019 , Nanobashvili et al., 2019 , Orive et al., 2019 , Paolone et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

Wahlberg

Emerich

Kordower

et al. 2020

Current Research in Pharmacology and Drug Discovery

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Delivering glial cell line-derived neurotrophic factor (GDNF) to the brain is a potential treatment for Parkinson's Disease (PD). Here we use an implantable encapsulated cell technology that uses modified human clonal ARPE-19 cells to deliver of GDNF to the brain. I n vivo studies demonstrated sustained delivery of GDNF to the rat striatum over 6 months. Anatomical benefits and behavioral efficacy were shown in 6-OHDA lesioned rats where nigral dopaminergic neurons were preserved in neuroprotection studies and dopaminergic fibers were restored in neurorecovery studies. When larger, clinical-sized devices were implanted for 3 months into the putamen of Göttingen minipigs, GDNF was widely distributed throughout the putamen and caudate producing a significant upregulation of tyrosine hydroxylase immunohistochemistry. These results are the first to provide clear evidence that implantation of encapsulated GDNF-secreting cells deliver efficacious and biologically relevant amounts of GDNF in a sustained and targeted manner that is scalable to treat the large putamen in patients with Parkinson's disease.

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Section: Discussionmentioning

confidence: 99%

Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

Wahlberg

Emerich

Kordower

et al. 2020

Current Research in Pharmacology and Drug Discovery

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“…[20,31] However, further study is necessary to improve the regulation of the inflammatory and angiogenesis responses of MSC-laden systems to achieve satisfactory skin flap regeneration. Unlike traditional MSC-laden systems that support cell survival, [19,32] anisotropic silk nanofiber microgels controlled MSCs to stimulate angiogenesis and an M1 to M2 phenotype switching of the macrophages, achieving scarless wound healing with hair follicles. [14] Thus, combining DFO-laden silk nanofiber hydrogels and MSC-laden microgels was pursued here to synergize angiogenesis and control of inflammatory reactions to improve the survival and regeneration of skin flaps with minimized necrosis.…”

Section: Characterization Of Different Hydrogelsmentioning

confidence: 99%

MSC‐Laden Composite Hydrogels for Inflammation and Angiogenic Regulation for Skin Flap Repair

Tian

Ding

et al. 2022

Advanced Therapeutics

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Pressure‐driven, spreadable, deferoxamine (DFO)‐laden hydrogels are developed toward treatment for improved skin flap tissue repair. Further, mesenchymal stem cells (MSCs) are incorporated into silk nanofiber systems and then added to silk hydrogels to optimize angiogenesis and moderate inflammatory reactions in skin flap tissues for repair. The combined (composite) systems result in improved tissue outcomes. For example, the DFO release from the hydrogels is maintained while the system moderated negative influences of DFO on cells at the skin flap site with improved vasculization and for control of immune reactions. Both in vitro and in vivo results reveal improved outcomes with these composite hydrogel systems when MSCs are included. The synergistic action of DFO‐laden silk nanofibers combined with MSC‐laden microgels results in improved functional recovery of skin flaps in vivo when compared to control systems. Considering the ease of use of this system toward clinical applications, these new hydrogels are candidates for skin flap regeneration in surgical settings.

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Novel nanocomposite scaffold based on gelatin/PLGA-PEG-PLGA hydrogels embedded with TGF-β1 for chondrogenic differentiation of human dental pulp stem cells in vitro

Ghandforoushan

Hanaee

Aghazadeh

et al. 2022

International Journal of Biological Macromolecules

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Advances in cell-laden hydrogels for delivering therapeutics

Cited by 3 publications

References 19 publications

Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

MSC‐Laden Composite Hydrogels for Inflammation and Angiogenic Regulation for Skin Flap Repair

Novel nanocomposite scaffold based on gelatin/PLGA-PEG-PLGA hydrogels embedded with TGF-β1 for chondrogenic differentiation of human dental pulp stem cells in vitro

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