Advances in chemistry and composition of soft materials for drug releasing contact lenses

Chatterjee, Subir; Upadhyay, Prashant; Mishra, Manjul; Srividya, Mallavarapu R.; Akshara, M. R.; Kamali, Naghmeh; Zaidi, Zahra Sifat; Iqbal, Sayeda F.; Misra, Santosh K.

doi:10.1039/d0ra06681h

Cited by 63 publications

(34 citation statements)

References 125 publications

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“…In 2002, Hiratani imprinted soft contact lenses using methacrylic acid (MAA) as functional monomers to incorporate timolol into N, N-diethyl acrylamide (DEA) and pHEMA hydrogels [ 56 , 90 , 91 ]. Alvarez-Lorenzo et al [ 92 ] used the same strategy to produce pHEMA contact lenses with the addition of norfloxacin.…”

Section: Drug Loading Techniquesmentioning

confidence: 99%

Soft Contact Lenses as Drug Delivery Systems: A Review

Rykowska

Nowak

Nowak³

2021

Molecules

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This review describes the role of contact lenses as an innovative drug delivery system in treating eye diseases. Current ophthalmic drug delivery systems are inadequate, particularly eye drops, which allow about 95% of the active substance to be lost through tear drainage. According to the literature, many interdisciplinary studies have been carried out on the ability of contact lenses to increase the penetration of topical therapeutic agents. Contact lenses limit drug loss by releasing the medicine into two layers of tears on either side of the contact lens, eventually extending the time of contact with the ocular surface. Thanks to weighted soft contact lenses, a continuous release of the drug over an extended period is possible. This article reviewed the various techniques to deliver medications through contact lenses, examining their advantages and disadvantages. In addition, the potential of drug delivery systems based on contact lenses has been extensively studied.

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Section: Drug Loading Techniquesmentioning

confidence: 99%

Soft Contact Lenses as Drug Delivery Systems: A Review

Rykowska

Nowak

Nowak³

2021

Molecules

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“…NVP plays a role as a functional monomer owing to its lactam part. The existence of bipolar lactam group makes it highly polar, thus inducing hydrophilicity [3] …”

Section: Materials Components For Cls Hydrogelsmentioning

confidence: 99%

“…Although DMA has been demonstrated to be more hydrophilic than HEMA, the extra addition of HEMA still can enhance the hydrophilicity and drug loading property [3,83] . For example, Xu et al .…”

Section: New Cls Hydrogels Via Rational Copolymer Designmentioning

confidence: 99%

“…However, traditional ophthalmic administration of drugs that contain eye drops, powder and ointment, have significant limitations in the application, such as low permeability, low bioavailability, short residence time, and frequent administration. Therefore, many studies attempt to overcome these shortcomings with diverse strategies, among which contact lenses (CLs) are recognized as one of the most promising carriers for ophthalmic administration [2–5] . In addition to the correction of myopia and cosmetics, CLs have also been emerged as a drug delivery platform for many years [6–9] .…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in New Copolymer Hydrogel‐Formed Contact Lenses for Ophthalmic Drug Delivery

Cheng

et al. 2021

ChemNanoMat

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Pharmaceuticals delivery to the eye sites of interest via the means of contact lenses (CLs) has attracted significant research attention in recent years. Compared with the conventional formulation in eye treatment such as eye drops, CLs administration has shown remarkable advantages in overcoming the challenges involved in ocular drug delivery such as higher bioavailability, longer drug residence and better medication compliance. This review will first detail each of the material components which have been used in the context of CLs, including HEMA, MAA, DMA, NVP, EGDMA, TRIS and PDMS. The pros and cons of each material in tailoring drug release rates of different encapsulated payloads will be discussed, with special focus on their impact on the therapeutic efficiency. In addition, the advancement of recent emerging copolymer CLs hydrogels, originated from these sophisticated monomers with distinct functions, are further summarized into several synthetic strategies in the means of copolymer architecture design and function‐performance relationship in ophthalmic applications. Finally, the possible considerations for future design of multifunctional CLs hydrogels by combing material selection rationales with biological interface science are proposed.

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“…Moreover, the stimulus-responsive volume changes sensitive to temperature, pH, solvent, and electric field enables them to be applied in various biomedical applications [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. In addition, the excellent optical and mechanical properties of the hydrogels can be applied to multifunctional contact lenses [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Photoinitiated Polymerization of Hydrogels by Graphene Quantum Dots

et al. 2021

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As a smart stimulus-responsive material, hydrogel has been investigated extensively in many research fields. However, its mechanical brittleness and low strength have mattered, and conventional photoinitiators used during the polymerization steps exhibit high toxicity, which limits the use of hydrogels in the field of biomedical applications. Here, we address the dual functions of graphene quantum dots (GQDs), one to trigger the synthesis of hydrogel as photoinitiators and the other to improve the mechanical strength of the as-synthesized hydrogel. GQDs embedded in the network effectively generated radicals when exposed to sunlight, leading to the initiation of polymerization, and also played a significant role in improving the mechanical strength of the crosslinked chains. Thus, we expect that the resulting hydrogel incorporated with GQDs would enable a wide range of applications that require biocompatibility as well as higher mechanical strength, including novel hydrogel contact lenses and bioscaffolds for tissue engineering.

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Advances in chemistry and composition of soft materials for drug releasing contact lenses

Abstract: Contact lens as controllable route for ocular drug delivery.

Cited by 63 publications

References 125 publications

Soft Contact Lenses as Drug Delivery Systems: A Review

Soft Contact Lenses as Drug Delivery Systems: A Review

Recent Advances in New Copolymer Hydrogel‐Formed Contact Lenses for Ophthalmic Drug Delivery

Photoinitiated Polymerization of Hydrogels by Graphene Quantum Dots

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