Advances in HbA1c Biosensor Development Based on Field Effect Transistors: A Review

Ahmadi, Anita; Kabiri, Shima; Omidfar, Kobra

doi:10.1109/jsen.2020.2987836

Cited by 10 publications

(7 citation statements)

References 82 publications

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“…Adanya anion borat ini akan berinteraksi dengan gugus cis-diol pada HbA1c sehingga dapat dipisahkan dari hemoglobin nonglikasi (Koval et al, 2011). Meskipun metode-metode tersebut memberikan presisi dan akurasi untuk pengukuran HbA1c, namun memerlukan biaya tinggi, kebutuhan instrument khusus, dan tenaga ahli untuk mengoprasikan (Ahmadi et al, 2020). Adanya gangguan variasi hemoglobin lain yang juga terukur dapat menjadi masalah saat menganalisis HbA1c, sehingga memberi efek pada keakuratan pengukuran HbA1c seperti memberi false normal (Gilani et al, 2020;Wang et al, 2021).…”

Section: Metode Pengukuran Hba1cunclassified

“…Penggunaan dan imobilisasi bioreseptor yang sesuai menjadi penting pada pengembangan biosensor. Umumnya, biokomponen yang digunakan pada pengembangan biosensor adalah enzim, antibodi, aptamer, atau DNA untai tunggal yang mengikat secara spesifik pada molekul yang diinginkan (Ahmadi et al, 2020). Namun aptamer dan antibodi/antigen adalah bioreseptor yang sering digunakan pada berbagai jenis biosensor.…”

Section: Biosensor Berdasarkan Jenis Bioreseptorunclassified

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Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus

2023

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Hiperglikemia merupakan ciri diabetes melitus, sekelompok penyakit metabolik yang disebabkan oleh kelainan sekresi insulin, kerja insulin, atau keduanya. Hiperglikemia dapat menyebabkan kerusakan jangka panjang, disfungsi, dan kegagalan berbagai organ, terutama jantung, mata, saraf, pembuluh darah, dan ginjal. Oleh karena itu, diagnosis dan pemantauan rutin kadar glukosa darah sangat penting dilakukan. Hemoglobin terglikasi (HbA1c) adalah hemoglobin yang berikatan dengan glukosa dalam darah dan ditetapkan menjadi biomarker hiperglikemia yang dapat mengindikasikan diabetes atau prediabetes. Akan tetapi, pengukuran HbA1c di laboratorium klinis membutuhkan instrumen yang canggih dan mahal, tenaga ahli khusus dan waktu lama. Oleh karena itu, biosensor elektrokimia kemudian mulai dikembangkan untuk mendeteksi kadar HbA1c karena mudah digunakan, hasil cepat, dan harga yang murah. Ulasan ini membahas biosensor elektrokimia untuk mendeteksi HbA1c dan metode imobilisasi bioreseptor.Electrochemical Biosensor for Monitoring Glycated Hemoglobin (HbA1c) Levels in Diabetes Mellitus. Hyperglycemia is a hallmark of diabetes mellitus, a group of metabolic diseases caused by defects in insulin action, insulin secretion, or both. Hyperglycemia can cause long-term damage, dysfunction, and failure of various organs, especially the heart, blood vessels, eyes, nerves, and kidneys.. Therefore, routine diagnosis and monitoring of blood glucose levels are very important. Glycated hemoglobin (HbA1c) is hemoglobin that binds to glucose in the blood and is established as a biomarker of hyperglycemia that may indicate diabetes or prediabetes. However, measurement of HbA1c in the clinical laboratory requires large and expensive instruments, specialized experts, and takes a long time. Therefore, an electrochemical biosensor began to be developed to detect HbA1c levels because it is easy to use and has fast results at lower prices. This review discusses electrochemical biosensors for detecting HbA1c and the immobilization of bioreceptors.

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Section: Metode Pengukuran Hba1cunclassified

Section: Biosensor Berdasarkan Jenis Bioreseptorunclassified

Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus

2023

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“…Although these methods frequently profit from good accuracy, reliability, and multiple sample processing, most of them suffer from the need for specialized expensive equipment, centralized services, infrastructure/or professional staff, and a lack of point-of-use (PoU) employment capabilities. The ASSURED criteria are an important guideline provided by the WHO for developing efficient POC devices to distinguish major human diseases (Syedmoradi et al, 2017;Ahmadi et al, 2020). Advances in digital health include mobile health, health information technology (IT), and wearable devices, and the acronym REASSURED (real-time connectivity, ease of specimen collection, affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free or simple environmentally friendly, deliverable to end-users) has been offered for the development of diagnostic methods to address vital priorities such as global health emergencies (Land et al, 2019;Mahmoudi et al, 2022).…”

Section: Future Outlookmentioning

confidence: 99%

Toward waterborne protozoa detection using sensing technologies

et al. 2023

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Drought and limited sufficient water resources will be the main challenges for humankind during the coming years. The lack of water resources for washing, bathing, and drinking increases the use of contaminated water and the risk of waterborne diseases. A considerable number of waterborne outbreaks are due to protozoan parasites that may remain active/alive in harsh environmental conditions. Therefore, a regular monitoring program of water resources using sensitive techniques is needed to decrease the risk of waterborne outbreaks. Wellorganized point-of-care (POC) systems with enough sensitivity and specificity is the holy grail of research for monitoring platforms. In this review, we comprehensively gathered and discussed rapid, selective, and easy-to-use biosensor and nanobiosensor technologies, developed for the early detection of common waterborne protozoa.

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“…In recent years, there has been great progress in the construction of biosensors and similar methods for the HbA 1c assay [ 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ]. Various optical and electro-optical sensor methods have been developed in the past few years.…”

Section: Biosensors and Bioassays Measuring Hba 1cmentioning

confidence: 99%

Glycated Hemoglobin and Methods for Its Point of Care Testing

Pohanka

2021

Biosensors

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Glycated hemoglobin (HbA1c) is a product of the spontaneous reaction between hemoglobin and elevated glucose levels in the blood. It is included among the so-called advanced glycation end products, of which is the most important for the clinical diagnosis of diabetes mellitus, and it can serve as an alternative to glycemia measurement. Compared to the diagnosis of diabetes mellitus by glycemia, the HbA1c level is less influenced by a short-term problem with diabetes compensation. Mass spectroscopy and chromatographic techniques are among the standard methods of HbA1c level measurement. Compared to glycemia measurement, there is lack of simple methods for diabetes mellitus diagnosis by means of the HbA1c assay using a point-of-care test. This review article is focused on the surveying of facts about HbA1c and its importance in diabetes mellitus diagnosis, and surveying standard methods and new methods suitable for the HbA1c assay under point-of-care conditions. Various bioassays and biosensors are mentioned and their specifications are discussed.

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Advances in HbA1c Biosensor Development Based on Field Effect Transistors: A Review

Cited by 10 publications

References 82 publications

Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus

Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus

Toward waterborne protozoa detection using sensing technologies

Glycated Hemoglobin and Methods for Its Point of Care Testing

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