Advances in Hemodynamic Analysis in Cardiovascular Diseases Investigation of Energetic Characteristics of Adult and Pediatric Sputnik Left Ventricular Assist Devices during Mock Circulation Support

Pugovkin, Alexander; Markov, Aleksandr; Селищев, С. В.; Korn, Leonie; Walter, Marian; Leonhardt, Steffen; Bockeriа, L.A.; Bockeria, O.L.; Telyshev, D. V.

doi:10.1155/2019/4593174

Cited by 17 publications

(5 citation statements)

References 29 publications

(35 reference statements)

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“…For heart function assessment, the most critical parameters monitored were heart rate, cardiac output, ejection fraction, fractional area change, and fractional shortening. Ischemic stroke, atherosclerosis, myocardial ischemia, hypertension, valvular heart disease, heart failure, and rheumatic heart diseases are some angiogenesis-dependent diseases closely related to abnormal hemodynamics (Pugovkin et al, 2019). Bevacizumab, Nintedanib, Pazopanib, Cediranib, Trebananib, and Sorafenib are some of the well-established compounds with anti-angiogenic properties.…”

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confidence: 99%

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Nathan,

Shameera,

Devarajan

et al. 2023

J of Applied Toxicology

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Angiogenesis and hemodynamic instability created by the irregular blood vessels causes hypoperfusion and angiogenesis‐mediated diseases. Therefore, therapies focusing on controlling angiogenesis will be a valuable approach to treat a broad spectrum of diseases. In this study, we explored the anti‐angiogenic potential of berberine (BBR) and also analyzed blood flow hemodynamics using zebrafish embryos. Zebrafish embryos treated with BBR (0.01–0.75 mM) at various doses at 1 hour post‐fertilization (hpf) developed a variety of phenotypic variations including aberrant blood vessels, tail bending, edema, and hemorrhage. Survival rates were much lower at higher dosages, and hatching rates were almost 99%, whereas control group appeared normal. Heart rate is an essential measure that has a strong association with hemodynamics. We used ImageJ software to study the heart rate of embryos treated with BBR, preceded by video processing. The resultant graph shows a significant decrease in heart rate of embryos treated with BBR in dose‐dependent manner. Also, RBC staining using o‐Dianisidine confirms the anti‐angiogenic potential of BBR by indicating the decrease in the intersegmental vessels at 0.5 and 0.75 mM treated embryos. Further, the gene expression study determined that the transcripts (vegf, vegfr2, nrp1a, hif‐1α, nos2a, nos2b, cox‐2a, and cox‐2b) measured were found to be downregulated by BBR at 0.5 mM concentration, from which we conclude that enos/vegf signaling could play an important role in modulating angiogenesis. Our data imply that BBR may be an effective compound for suppressing angiogenesis in vivo, which might be helpful in the treatment of vascular disorders like cancer and diabetic retinopathy in future.

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confidence: 99%

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Nathan,

Shameera,

Devarajan

et al. 2023

J of Applied Toxicology

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“…HVAD pump flow ( Q VAD ) was measured by a flow meter at the outflow tube (PXL Clamp-on Tubing Flow sensor ME10PXL-Transonic-ts410). Finally, the cardiac power ( CP ) of the HVAD was calculated with the following formula 17 :…”

Section: Methodsmentioning

confidence: 99%

Potential of Medical Management to Mitigate Suction Events in Ventricular Assist Device Patients

et al. 2022

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Ventricular suction is a common adverse event in ventricular assist device (VAD) patients and can be due to multiple underlying causes. The aim of this study is to analyze the potential of different therapeutic interventions to mitigate suction events induced by different pathophysiological conditions. To do so, a suction module was embedded in a cardiovascular hybrid (hydraulic-computational) simulator reproducing the entire cardiovascular system. An HVAD system (Medtronic) was connected between a compliant ventricular apex and a simulated aorta. Starting from a patient profile with severe dilated cardiomyopathy, four different pathophysiological conditions leading to suction were simulated: hypovolemia (blood volume: −900 ml), right ventricular failure (contractility −70%), hypotension (systemic vascular resistance: 8.3 Wood Units), and tachycardia (heart rate:185 bpm). Different therapeutic interventions such as volume infusion, ventricular contractility increase, vasoconstriction, heart rate increase, and pump speed reduction were simulated. Their effects were compared in terms of general hemodynamics and suction mitigation. Each intervention elicited a different effect on the hemodynamics for every pathophysiological condition. Pump speed reduction mitigated suction but did not ameliorate the hemodynamics. Administering volume and inducing a systemic vasoconstriction were the most efficient interventions in both improving the hemodynamics and mitigating suction. When simulating volume infusion, the cardiac powers increased, respectively, by 38%, 25%, 42%, and 43% in the case of hypovolemia, right ventricular failure, hypotension, and tachycardia. Finally, a management algorithm is proposed to identify a therapeutic intervention suited for the underlying physiologic condition causing suction.

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“…Control issues of the LVAD presented in Figure 2 include: (1) The discrepancy between the parameters that need to be controlled ensuring circulatory support (i.e., P 1 , P 2 , Q 1 , Q 3 ); (2) the parameters generated by the continuous-flow rotary pump (H, Q 2 ); and (3) the parameters that can be tracked and changed in real-time during LVAD support (I, ω). It was previously shown that there are ways to find correlations between different parameters using: (1) A ratio between the maximum flow acceleration and flow pulsatility at baseline pump speed as an alternative to a regression coefficient between the maximum flow acceleration and flow pulsatility at different pump speeds [25]; (2) the external work of the ventricle expressed by the area inside the P-V diagrams which correlates with the area inside dynamic H-Q curves [26]; or (3) energetic characteristics of LV-LVAD interaction [27]. Our hypothesis is that changes in the work (A) of the left ventricle affect the recorded parameter of the electric current (I).…”

Section: Correlation Between Cvs and Pump Parametersmentioning

confidence: 99%

Correlation between Myocardial Function and Electric Current Pulsatility of the Sputnik Left Ventricular Assist Device: In-Vitro Study

et al. 2021

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This study assesses the electric current parameters and reports on the analysis of the associated degree of myocardial function during left ventricular assist device (LVAD) support. An assumption is made that there is a correlation between cardiac output and the pulsatility index of the pump electric current. The experimental study is carried out using the ViVitro Pulse Duplicator System with Sputnik LVAD connected. Cardiac output and cardiac power output are used as a measure of myocardial function. Different heart rates (59, 73, 86 bpm) and pump speeds (7600–8400 rpm in 200 rpm steps) are investigated. In our methodology, ventricular stroke volumes in the range of 30–80 mL for each heart rate at a certain pump speed were used to simulate different levels of contractility. The correlation of the two measures of myocardial function and proposed pulsatility index was confirmed using different correlation coefficients (values ≥ 0.91). Linear and quadratic models for cardiac output and cardiac power output versus pulsatility index were obtained using regression analysis of measured data. Coefficients of determination for CO and CPO models were in the ranges of 0.914–0.982 and 0.817–0.993, respectively. Study findings suggest that appropriate interpretation of parameters could potentially serve as a valuable clinical tool to assess myocardial therapy using LVAD infrastructure.

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Advances in Hemodynamic Analysis in Cardiovascular Diseases Investigation of Energetic Characteristics of Adult and Pediatric Sputnik Left Ventricular Assist Devices during Mock Circulation Support

Cited by 17 publications

References 29 publications

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Potential of Medical Management to Mitigate Suction Events in Ventricular Assist Device Patients

Correlation between Myocardial Function and Electric Current Pulsatility of the Sputnik Left Ventricular Assist Device: In-Vitro Study

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