Advances in Imaging Reactive Oxygen Species

Espinoza, Eli M.; Røise, Joachim Justad; Li, I-Che; Das, Rahul; Murthy, Niren

doi:10.2967/jnumed.120.245415

Cited by 22 publications

(8 citation statements)

References 35 publications

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“…Traditional methods (like fluorescent probes, chemical analysis, electron spin resonance, etc. ) 84 - 88 are difficult to detect RONS in the kidney because of their significant limitations such as poor tissue permeability and low kidney-specific distribution. The detection of RONS in the kidney must meet the following requirements.…”

Section: Rons Imaging Probesmentioning

confidence: 99%

Emerging early diagnostic methods for acute kidney injury

Xiao¹,

Huang²,

Yang³

et al. 2022

Theranostics

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Many factors such as trauma and COVID-19 cause acute kidney injury (AKI). Late AKI have a very high incidence and mortality rate. Early diagnosis of AKI provides a critical therapeutic time window for AKI treatment to prevent progression to chronic renal failure. However, the current clinical detection based on creatinine and urine output isn't effective in diagnosing early AKI. In recent years, the early diagnosis of AKI has made great progress with the advancement of information technology, nanotechnology, and biomedicine. These emerging methods are mainly divided into two aspects: First, predicting AKI through models construct by machine learning; Second, early diagnosis of AKI through detection of newly-discovered early biomarkers. Currently, these methods have shown great potential and become an attractive tool for the early diagnosis of AKI. Therefore, it is very important to discuss and summarize these methods for the early diagnosis of AKI. In this review, we first systematically summarize the application of machine learning in AKI prediction algorithms and specific scenarios. In addition, we introduce the key role of early biomarkers in the progress of AKI, and then comprehensively summarize the application of emerging detection technologies for early AKI. Finally, we discuss current challenges and prospects of machine learning and biomarker detection. The review is expected to provide new insights for early diagnosis of AKI, and provided important inspiration for the design of early diagnosis of other major diseases.

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Section: Rons Imaging Probesmentioning

confidence: 99%

Emerging early diagnostic methods for acute kidney injury

Xiao¹,

Huang²,

Yang³

et al. 2022

Theranostics

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“…Tracers for imaging the content of reactive oxygen species (ROS) in tumors could be valuable for PET imaging of tumors and contribute to our knowledge of the biodistribution of anticancer drug candidates that are ROS-dependently trapped in tumor cells [54]. A click chemistry-based 18 F-fluoroglycoconjugation of N-alkylaminoferrocene as a potential anticancer agent was optimized by Toms et al, employing 14 and Cu(OAc) 2, phosphate buffer/THF, and sodium ascorbate for the CuAAC reaction conditions [55].…”

Section: -Deoxy-6-[ 18 F]fluoro-β-glycosyl Azides For Click Chemistry-based 18 F-fluoroglycosylationmentioning

confidence: 99%

Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects

2021

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In the field of 18F-chemistry for the development of radiopharmaceuticals for positron emission tomography (PET), various labeling strategies by the use of prosthetic groups have been implemented, including chemoselective 18F-labeling of biomolecules. Among those, chemoselective 18F-fluoroglycosylation methods focus on the sweetening of pharmaceutical radiochemistry by offering a highly valuable tool for the synthesis of 18F-glycoconjugates with suitable in vivo properties for PET imaging studies. A previous review covered the various 18F-fluoroglycosylation methods that were developed and applied as of 2014 (Maschauer and Prante, BioMed. Res. Int. 2014, 214748). This paper is an updated review, providing the recent progress in 18F-fluoroglycosylation reactions and the preclinical application of 18F-glycoconjugates, including small molecules, peptides, and high-molecular-weight proteins.

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“…Fluorescence-based imaging systems and probes are widely used for the measurement of a broad spectrum of ROS ( 9 ). Elevation of ROS above baseline levels (e.g.…”

Section: Fluorescent Probesmentioning

confidence: 99%

Latest Advances in Imaging Oxidative Stress in Cancer

Greenwood

Witney

2021

J Nucl Med

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Oxidative stress is the imbalance of harmful reactive oxygen species (ROS) and the action of neutralizing antioxidant mechanisms. If left unchecked, the deleterious effects of oxidative stress results in damage to DNA, proteins, and membranes, ultimately leading to cell death. Tumors are highly proliferative and consequently generate high levels of mitochondrial ROS. To compensate and maintain redox homeostasis, cancer cells upregulate protective antioxidant pathways, which are further amplified in drug-resistant tumors. This review provides an overview of the latest molecular imaging techniques designed to image oxidative stress in cancer. New probes are now able to assess heterogeneous ROS and antioxidant production within tumors and across lesions.Together, the non-invasive imaging of these dynamic processes holds great promise for treatment response monitoring, prediction of drug resistance, and may provide insight into the metastatic potential of tumors.

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Advances in Imaging Reactive Oxygen Species

Cited by 22 publications

References 35 publications

Emerging early diagnostic methods for acute kidney injury

Emerging early diagnostic methods for acute kidney injury

Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation: Recent Progress and Future Prospects

Latest Advances in Imaging Oxidative Stress in Cancer

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