Advances in long non-coding RNA regulating drug resistance of cancer

Ying, Zhang; Wenjing, Sun; Jing, Bai; Songbin, Fu; Kexian, Dong

doi:10.1016/j.gene.2023.147726

Cited by 5 publications

(1 citation statement)

References 105 publications

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“…LncRNAs can induce apoptosis resistance in tumor cells by up-regulating pro-survival factors such as Bcl-2, nuclear factor-kappaB (NF-κB) and inhibitor of apoptosis protein (IAP), or inhibits the expression of tumor suppressor genes like caspase and p53, leading to drug resistance. 20 (4) Epithelial mesenchymal Transformation (EMT) and Tumor stem Cell Formation (CSC). After chemotherapy, tumor cells undergo EMT, which leads to secondary drug resistance.…”

Section: Lncrna Drug Resistance Mechanismsmentioning

confidence: 99%

Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm

Zhang,

Wu,

Wang

et al. 2024

DDDT

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In the past few decades, chemotherapy has been one of the most effective cancer treatment options. Drug resistance is currently one of the greatest obstacles to effective cancer treatment. Even though drug resistance mechanisms have been extensively investigated, they have not been fully elucidated. Recent genome-wide investigations have revealed the existence of a substantial quantity of long non-coding RNAs (lncRNAs) transcribed from the human genome, which actively participate in numerous biological processes, such as transcription, splicing, epigenetics, the cell cycle, cell differentiation, development, pluripotency, immune microenvironment. The abnormal expression of lncRNA is considered a contributing factor to the drug resistance. Furthermore, drug resistance may be influenced by genetic and epigenetic variations, as well as individual differences in patient treatment response, attributable to polymorphisms in metabolic enzyme genes. This review focuses on the mechanism of lncRNAs resistance to target drugs in the study of tumors with high mortality, aiming to establish a theoretical foundation for targeted therapy.

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Section: Lncrna Drug Resistance Mechanismsmentioning

confidence: 99%