Advances in Microfluidic Paper-Based Analytical Devices for Food and Water Analysis

Busa, Lori Shayne Alamo; Mohammadi, Saeed; Maeki, Masatoshi; Ishida, Akihiko; Tani, Hirofumi

doi:10.3390/mi7050086

Cited by 181 publications

(92 citation statements)

References 71 publications

(204 reference statements)

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“…The most commonly used paper for PAD fabrication is Whatman filter paper grade 1. Other types of paper can also be used such as Whatman chromatography paper 3 MM Chr, Whatman filter paper grade 4, Whatman RC60 regenerated cellulose membrane filter, Millipore MCE membrane filter, Canson paper, Fisherbrand P5 filter paper, JProLab JP 40 filter paper, Advantec 51B chromatography paper, and Ahlstrom 319 paper .…”

Section: Fabrication and Detection Techniquesmentioning

confidence: 99%

Recent applications of paper‐based point‐of‐care devices for biomarker detection

Suntornsuk

2019

Electrophoresis

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Detection of biomarkers is essential for diagnosis and prognosis of diseases for healthcare teams to provide timely appropriate treatments. Reliable, inexpensive, and sensitive devices are desirable to serve this purpose. Paper‐based analytical devices (PADs) have gained enormous attention during the past decade as point‐of‐care devices for biomarker detection due to their simplicity, portability, and biocompatibility. Importantly, the devices highly comply with the WHO “ASSURED” concept (i.e. Affordable, Sensitive, Specific, User‐friendly, Rapid and Robust, Equipment free, and Deliverable to end‐users). Thus, PADs could be sustainably alternative tools for biomarker detection, especially in resources‐constraint areas where budget, skillful operators, and health infrastructure are limited. First, this review introduces overviews of biomarkers, their detection and brief history of PADs. Second, description of common fabrication and detection techniques in PADs are provided. Then, it highlights recent state of the art technologies and applications of PADs for various biomarker detection published during 2018 to May 2019. Applications for tumor marker, cardiac and coronary heath disease, and metabolic disorder biomarker detection are tabulated and selected examples are described in details. Finally, it discusses the current challenges, advances, and novel applications of PADs. The review would be valuable for healthcare workers using PADs as cost‐effective point‐of‐care devices for biomarker detection and for researchers working on future developments of the devices.

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Section: Fabrication and Detection Techniquesmentioning

confidence: 99%

Recent applications of paper‐based point‐of‐care devices for biomarker detection

Suntornsuk

2019

Electrophoresis

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“…Recently, microfluidic paper-based analytical devices (μPADs) have attracted a lot of attention and have been actively developed due to being simple, inexpensive, user-friendly, and disposable. [12][13][14][15][16] To date, μPADs have been used as elegant analytical tools for a variety of applications, including medical diagnosis, [17][18][19][20][21] food testing, 22 and environmental monitoring. [23][24][25][26][27][28][29] A lot of detection methods have been used for μPADs.…”

Section: Crmentioning

confidence: 99%

Microfluidic Paper-based Analytical Device for the Determination of Hexavalent Chromium by Photolithographic Fabrication Using a Photomask Printed with 3D Printer

Asano

Shiraishi

2018

ANAL. SCI.

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This article describes a simple and inexpensive microfluidic paper-based analytical device (μPAD) for the determination of hexavalent chromium (Cr VI ) in water samples. The μPADs were fabricated on paper by photolithography using a photomask printed with a 3D printer and functionalized with reagents for a colorimetric assay. In the μPAD, Cr VI reacts with 1,5-diphenylcarbazide to form a violet-colored complex. Images of μPADs were captured with a digital camera; then the red, green, and blue color intensity of each detection zone were measured using images processing software. The green intensity analysis was the best sensitive among the RGB color. A linear working range (40 -400 ppm; R 2 = 0.981) between the Cr VI and green intensity was obtained with a detection limit of 30 ppm. All of the recoveries were between 94 and 109% in recovery studies on water samples, and good results were obtained.

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“…Apart from facing all these critical steps for achieving industry acceptance and AOAC/regulatory approvals, recent trends in the development of electrochemical biosensor for food quality and safety include the use of paper-based platforms [153][154][155][156][157] the development of portable multiplexed biosensing platforms able to be integrated in single lab-on-a-chip microfluidics devicescomprising sample extraction, separation and sensing units, which would greatly improve portability for field use, and the exploration of new nanomanufacturing techniques, such as 3D printing, in their fabrication.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Electrochemical Affinity Biosensors in Food Safety

2017

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Safety and quality are key issues of today's food industry. Since the food chain is becoming more and more complex, powerful analytical methods are required to verify the performance of food safety and quality systems. Indeed, such methods require high sensitivity, selectivity, ability for rapid implementation and capability of automatic screening. Electroanalytical chemistry has, for decades, played a relevant role in food safety and quality assessment, taking more and more significance over time in the solution of analytical problems. At present, the implementation of electrochemical methods in the food is evident. This is in a large part due to the relevant results obtained by combining the attractive advantages of electrochemical transduction strategies (in terms of relatively simple hardware, versatility, interface with automatic logging and feasibility of application outside the laboratory environment) with those from biosensors technology. Important examples of enzyme electrochemical biosensors are those dedicated to the determination of glucose, alcohol or cholesterol are important examples. In addition, other types of different electrochemical biosensing approaches have emerged strongly in the last years. Among these, the strategies involving affinity interactions have been shown to possess a large number of applications. Therefore, electrochemical immunosensors and DNA-based biosensors have been widely used to determine major and minor components in foodstuffs, providing sufficient data to evaluate food freshness, the quality of raw materials, or the origin of samples, as well as to determine a variety of compounds at trace levels related to food safety such as micotoxins, allergens, drugs residues or pathogen microorganisms. This review discusses some critical examples of the latest advances in this area, pointing out relevant methodologies related to the measurement techniques, including the use of nanostructured electrodes and strategies for signal amplification.

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Advances in Microfluidic Paper-Based Analytical Devices for Food and Water Analysis

Cited by 181 publications

References 71 publications

Recent applications of paper‐based point‐of‐care devices for biomarker detection

Recent applications of paper‐based point‐of‐care devices for biomarker detection

Microfluidic Paper-based Analytical Device for the Determination of Hexavalent Chromium by Photolithographic Fabrication Using a Photomask Printed with 3D Printer

Electrochemical Affinity Biosensors in Food Safety

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