Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

Maeki, Masatoshi; Kimura, Niko; Sato, Yusuke; Harashima, Hideyoshi; Tokeshi, Manabu

doi:10.1016/j.addr.2018.03.008

Cited by 252 publications

(174 citation statements)

References 138 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…Microfluidic approaches to liposome production are based on the application of various geometries of mixing channel as well as the application of shear forces, electric field or various microfluidics effects taking place in the channel. A comprehensive review was published recently by Carugo et al 8 , Wang et al 9 and Maeki 10,11 . Theoretical models describing kinetic and thermodynamic parameters that determine the formation of liposomes from lipid bilayer disc were described [12][13][14][15] .…”

Section: Introduction Of Microfluidic Mixing Technique Opens a New Domentioning

confidence: 99%

Preparation of nanoliposomes by microfluidic mixing in herring-bone channel and the role of membrane fluidity in liposomes formation

Kotouček

Hubatka

Mašek

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Introduction of microfluidic mixing technique opens a new door for preparation of the liposomes and lipid-based nanoparticles by on-chip technologies that are applicable in a laboratory and industrial scale. This study demonstrates the role of phospholipid bilayer fragment as the key intermediate in the mechanism of liposome formation by microfluidic mixing in the channel with “herring-bone” geometry used with the instrument NanoAssemblr. The fluidity of the lipid bilayer expressed as fluorescence anisotropy of the probe N,N,N-Trimethyl-4-(6-phenyl-1,3,5-hexatrien-1-yl) was found to be the basic parameter affecting the final size of formed liposomes prepared by microfluidic mixing of an ethanol solution of lipids and water phase. Both saturated and unsaturated lipids together with various content of cholesterol were used for liposome preparation and it was demonstrated, that an increase in fluidity results in a decrease of liposome size as analyzed by DLS. Gadolinium chelating lipids were used to visualize the fine structure of liposomes and bilayer fragments by CryoTEM. Experimental data and theoretical calculations are in good accordance with the theory of lipid disc micelle vesiculation.

show abstract

Section: Introduction Of Microfluidic Mixing Technique Opens a New Domentioning

confidence: 99%

Preparation of nanoliposomes by microfluidic mixing in herring-bone channel and the role of membrane fluidity in liposomes formation

Kotouček

Hubatka

Mašek

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…[65,66] The rapid development of micro-and nanofabrication techniques have largely contributed to the revolution of microfluidic device, and previous reviews have summarized primary methods for design of microfluidic device in detail. [67,68] Two dominant types of microfluidic chips were used in generating various types of NMs. [69][70][71] One is glass capillary microfluidic chip that has advantages of high chemical resistance and ideal coaxial construction.…”

Section: Doi: 101002/smll201901943mentioning

confidence: 99%

“…Fabrication of microfluidic chips with well‐defined geometry and material compatibility is the first and fundamental step for generating NMs by microfluidics . The rapid development of micro‐ and nanofabrication techniques have largely contributed to the revolution of microfluidic device, and previous reviews have summarized primary methods for design of microfluidic device in detail . Two dominant types of microfluidic chips were used in generating various types of NMs .…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Generation of Nanomaterials for Biomedical Applications

Zhao

Bian

Sun

et al. 2019

Small

View full text Add to dashboard Cite

As nanomaterials (NMs) possess attractive physicochemical properties that are strongly related to their specific sizes and morphologies, they are becoming one of the most desirable components in the fields of drug delivery, biosensing, bioimaging, and tissue engineering. By choosing an appropriate methodology that allows for accurate control over the reaction conditions, not only can NMs with high quality and rapid production rate be generated, but also designing composite and efficient products for therapy and diagnosis in nanomedicine can be realized. Recent evidence implies that microfluidic technology offers a promising platform for the synthesis of NMs by easy manipulation of fluids in microscale channels. In this Review, a comprehensive set of developments in the field of microfluidics for generating two main classes of NMs, including nanoparticles and nanofibers, and their various potentials in biomedical applications are summarized. Furthermore, the major challenges in this area and opinions on its future developments are proposed.

show abstract

“…Microfluidics‐based nanoparticles exhibit distinct properties for drug delivery, which allow precise encapsulation and controlled release of active agents. Recent innovations and advances of microfluidics greatly accelerate the clinical translation of nanoparticles . Apart from the size and composition, the biocompatibility, surface properties, and even rigidity of nanoparticles can be designed in microfluidic system, which have great influence on the cellular uptake.…”

Section: Microfluidics‐based Biomaterialsmentioning

confidence: 99%

Microfluidics‐Based Biomaterials and Biodevices

et al. 2018

View full text Add to dashboard Cite

The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201805033.The rapid development of microfluidics technology has promoted new innovations in materials science, particularly by interacting with biological systems, based on precise manipulation of fluids and cells within microscale confinements. This article reviews the latest advances in microfluidics-based biomaterials and biodevices, highlighting some burgeoning areas such as functional biomaterials, cell manipulations, and flexible biodevices. These areas are interconnected not only in their basic principles, in that they all employ microfluidics to control the makeup and morphology of materials, but also unify at the ultimate goals in human healthcare. The challenges and future development trends in biological application are also presented. Microfluidics

show abstract

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

Cited by 252 publications

References 138 publications

Preparation of nanoliposomes by microfluidic mixing in herring-bone channel and the role of membrane fluidity in liposomes formation

Preparation of nanoliposomes by microfluidic mixing in herring-bone channel and the role of membrane fluidity in liposomes formation

Microfluidic Generation of Nanomaterials for Biomedical Applications

Microfluidics‐Based Biomaterials and Biodevices

Contact Info

Product

Resources

About