Advances in microneedle-based therapy for bone disorders

Lin, Zengping; Zheng, Keyan; Zhong, Jiping; Zheng, Xiaoxu

doi:10.1016/j.biopha.2023.115013

Cited by 6 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bone diseases are a recurring problem in the general population and are presented in diverse ways leading to mass bone loss [ 1 ]. New treatments are studied to solve this problem with less collateral effect and good efficacy [ 31 ]. In this way, we hypothesize that a new formulation of HT-NE may permit a controlled release of HT and provide safe treatment techniques, in addition to enhancing its biocompatibility and biological activities.…”

Section: Discussionmentioning

confidence: 99%

Formulation of a Novel Hesperetin-Loaded Nanoemulsion and Its Promising Effect on Osteogenesis

Mancim-Imbriani,

Duarte,

Di Filippo

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Alternative therapies associating natural products and nanobiotechnology show new perspectives on controlled drug release. In this context, nanoemulsions (NEs) present promising results for their structural design and properties. Hesperetin (HT), a flavonoid mainly found in citrus fruits, presents highlighted bone benefits. In this context, we developed a hesperetin-loaded nanoemulsion (HT-NE) by sonication method and characterized it by dynamic light scattering, analyzing its encapsulation efficiency, and cumulative release. The biocompatibility in human osteoblasts Saos-2-like was evaluated by the cytotoxicity assay and IC50. Then, the effects of the HT-NE on osteogenesis were evaluated by the cellular proliferation, calcium nodule formation, bone regulators gene expression, collagen quantification, and alkaline phosphatase activity. The results showed that the formulation presented ideal values of droplet size, polydispersity index, and zeta potential, and the encapsulation efficiency was 74.07 ± 5.33%, showing a gradual and controlled release. Finally, HT-NE was shown to be biocompatible and increased cellular proliferation, and calcium nodule formation, regulated the expression of Runx2, ALPL, and TGF-β genes, and increased the collagen formation and alkaline phosphatase activity. Therefore, the formulation of this NE encapsulated the HT appropriately, allowing the increasing of its effects on mechanisms to improve or accelerate the osteogenesis process.

show abstract

Section: Discussionmentioning

confidence: 99%

Formulation of a Novel Hesperetin-Loaded Nanoemulsion and Its Promising Effect on Osteogenesis

Mancim-Imbriani,

Duarte,

Di Filippo

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…In an attempt to mimic the physiology of bone, various morphologies of silk fibroin have been investigated for the delivery of bone specific growth factors (such as BMP-2, platelet-derived growth factors), with a crucial role in promoting osteogenesis for the application in bone regeneration [82]. In the prevention and management of bone-related disorders, despite the progress of the conventional drug delivery systems, the limited drug absorption and lack of specificity in therapeutic outcomes have encouraged the use of microneedle-based therapy as a safe and well-tolerable therapeutic approach [83]. For example, a composite microneedles system consisting of silk fibroin needle tips and a hyaluronic acid base has been developed by Li et al for the transdermal delivery of salmon calcitonin for the treatment of osteoporosis.…”

Section: Applications Of Silk Fibroin In Ddssmentioning

confidence: 99%

The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

Pollini,

Paladini

2024

Biomimetics

View full text Add to dashboard Cite

In order to reduce the toxicological impact on healthy cells and to improve the therapeutic response, many drug delivery systems have been fabricated and analysed, involving the use of different natural and synthetic materials at macro-, micro- and nanoscales. Among the natural materials which have demonstrated a huge potential for the development of effective drug delivery systems, silk fibroin has emerged for its excellent biological properties and for the possibility to be processed in a wide range of forms, which can be compliant with multiple active molecules and pharmaceutical ingredients for the treatment of various diseases. This review aims at presenting silk fibroin as an interesting biopolymer for applications in drug delivery systems, exploring the results obtained in recent works in terms of technological progress and effectiveness in vitro and in vivo.

show abstract

Innovative technologies for the fabrication of 3D/4D smart hydrogels and its biomedical applications - A comprehensive review

Shashikumar,

Saraswat,

Deshmukh

et al. 2024

Advances in Colloid and Interface Science

View full text Add to dashboard Cite

Advances in microneedle-based therapy for bone disorders

Cited by 6 publications

References 47 publications

Formulation of a Novel Hesperetin-Loaded Nanoemulsion and Its Promising Effect on Osteogenesis

Formulation of a Novel Hesperetin-Loaded Nanoemulsion and Its Promising Effect on Osteogenesis

The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

Innovative technologies for the fabrication of 3D/4D smart hydrogels and its biomedical applications - A comprehensive review

Contact Info

Product

Resources

About