Advances in multi-omics research on viral hepatitis

Xiang, Ze; Li, Jiayuan; Lu, Di; Wei, Xuyong; Xu, Xiao Chun

doi:10.3389/fmicb.2022.987324

Cited by 22 publications

(19 citation statements)

References 106 publications

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“…Metabolomics is one of the important components of system biology, which is the science of studying the type, quantity and change law of metabolites after an organism is perturbed ( Johnson et al., 2016 ; Wu et al., 2022b ). Metabolomics can reflect a series of biological events that occur in a pathophysiological process by revealing the trajectory of the overall metabolism under the influence of internal and external factors ( Tian et al., 2022 ; Xiang et al., 2022 ). Studying CI through metabolomics can reveal its molecular signature and elucidate potential pathological pathways in which diseases are disturbed ( Table 2 ).…”

Section: Metabolomics and Cerebral Infarctionmentioning

confidence: 99%

The roles and mechanisms of gut microbiome and metabolome in patients with cerebral infarction

Qian

et al. 2023

Front. Cell. Infect. Microbiol.

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As the most common type of stroke, ischemic stroke, also known as cerebral infarction (CI), with its high mortality and disability rate, has placed a huge burden on social economy and public health. Treatment methods for CI mainly include thrombectomy, thrombolysis, drug therapy, and so on. However, these treatments have certain timeliness and different side effects. In recent years, the gut-brain axis has become a hot topic, and its role in nervous system diseases has been confirmed by increasing evidences. The intestinal microbiota, as an important part of the gut-brain axis, has a non-negligible impact on the progression of CI through mechanisms such as inflammatory response and damage-associated molecular patterns, and changes in the composition of intestinal microbiota can also serve as the basis for predicting CI. At the same time, the diagnosis of CI requires more high-throughput techniques, and the analysis method of metabolomics just fits this demand. This paper reviewed the changes of intestinal microbiota in patients within CI and the effects of the intestinal microbiota on the course of CI, and summarized the therapeutic methods of the intervention with the intestinal microbiota. Furthermore, metabolic changes of CI patients were also discussed to reveal the molecular characteristics of CI and to elucidate the potential pathologic pathway of its interference.

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Section: Metabolomics and Cerebral Infarctionmentioning

confidence: 99%

The roles and mechanisms of gut microbiome and metabolome in patients with cerebral infarction

Qian

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Proteomics applications offer fresh approaches to HBV occurrence, development, and replication. 26 Modifications to the genome can lead to overexpression of proteins. In a small percentage of tumour samples, many recognised protein targets in HBV-related liver cancer are overexpressed, where their inhibition may be effective.…”

Section: Proteomicsmentioning

confidence: 99%

“…Proteomics applications offer fresh approaches to HBV occurrence, development, and replication 26 . Modifications to the genome can lead to overexpression of proteins.…”

Section: Histomolecular Characterisation Of Hbv Induced Liver Cancermentioning

confidence: 99%

Histomolecular characterisation of hepatitis B virus induced liver cancer

Adugna

2023

Reviews in Medical Virology

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Hepatitis B virus (HBV)‐associated liver cancer is the third most prevalent cancer‐related cause of death worldwide. Different studies have been done on the histomolecular analysis of HBV induced‐liver cancer including epigenetics which are dynamic molecular mechanisms to control gene expression without altering the host deoxyribonucleic acid, genomics characterise the integration of the viral genome with host genome, proteomics characterise how gene modifies and results overexpression of proteins, glycoproteomics discover different glyco‐biomarker candidates and show glycosylation in malignant hepatocytes, metabolomics characterise how HBV impairs a variety of metabolic functions during hepatocyte immortalisation, exosomes characterise immortalised liver cells in terms of their differentiation and proliferation, and autophagy plays a role in the development of hepatocarcinogenesis linked to HBV infection.

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“…Liver is the largest solid organ in the body and plays an important role in the metabolic transformation and detoxification of food and drugs, so it is easily damaged by chemicals, alcohol, drugs and other substances. 87 Hepatitis is a major problem affecting public health and is receiving increasing attention. Early diagnosis and monitoring of the treatment process of hepatitis is important for its treatment and prognosis.…”

Section: Small-molecule Fluorescent Probes Using In Inflammatory Dise...mentioning

confidence: 99%

Small-molecule fluorescent probes for bioactive species in inflammatory disease: arthritis, pneumonia and hepatitis

Zhang,

Tang,

Shu

et al. 2023

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Advances in multi-omics research on viral hepatitis

Cited by 22 publications

References 106 publications

The roles and mechanisms of gut microbiome and metabolome in patients with cerebral infarction

The roles and mechanisms of gut microbiome and metabolome in patients with cerebral infarction

Histomolecular characterisation of hepatitis B virus induced liver cancer

Small-molecule fluorescent probes for bioactive species in inflammatory disease: arthritis, pneumonia and hepatitis

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