Advances in nanomaterials as novel elicitors of pharmacologically active plant specialized metabolites: current status and future outlooks

Anjum, Sumaira; Anjum, Iram; Hano, Christophe; Kousar, Sidra

doi:10.1039/c9ra08457f

Cited by 105 publications

(39 citation statements)

References 118 publications

(170 reference statements)

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“…It is accepted that NPs may have both beneficial and harmful effects on plants, in particular depending on the concentration [ 16 ]. Many reports have shown that when used at a lower concentration, NPs can promote plant growth and the production of secondary metabolites [ 17 ]. It may be due to NP interaction with some of the plant cell wall and membrane components [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Many reports have shown that when used at a lower concentration, NPs can promote plant growth and the production of secondary metabolites [ 17 ]. It may be due to NP interaction with some of the plant cell wall and membrane components [ 17 ]. The structure of the plant cell wall is consistent with the size of the NPs for entry into the cell where the reactive oxygen species (ROS) accumulation can be triggered [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress induction is a common response of plants to nanoparticle (NP) exposure because of their toxicity, but also as an inductive signal for the production of antioxidant secondary metabolites [ 17 ]. Enzymatic antioxidant response also contributes to the control of oxidative stress induced by NPs.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Biogenic Zinc Oxide Nanoparticles on Growth and Oxidative Stress Response in Flax Seedlings vs. In Vitro Cultures: A Comparative Analysis

et al. 2020

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Linum usitatissimum biosynthesizes lignans and neolignans that are diet and medicinally valuable metabolites. In recent years, zinc oxide nanoparticles (ZnONPs) have emerged as potential elicitors for the enhanced biosynthesis of commercial secondary metabolites. Herein, we investigated the influence of biogenic ZnONPs on both seedlings and stem-derived callus of L. usitatissimum. Seedlings of L. usitatissimum grown on Murashige and Skoog (MS) medium supplemented with ZnONPs (1–1000 mg/L) presented the highest antioxidant activity, total phenolic content, total flavonoid content, peroxidase and superoxide dismutase activities at 500 mg/L, while the maximum plantlet length was achieved with 10 mg/L. Likewise, the high-performance liquid chromatography (HPLC) analysis revealed the enhanced production of secoisolariciresinol diglucoside, lariciresinol diglucoside, dehydrodiconiferyl alcohol glucoside and guaiacylglycerol-β-coniferyl alcohol ether glucoside in the plantlets grown on the 500 mg/L ZnONPs. On the other hand, the stem explants were cultured on MS media comprising 1-naphthaleneacetic acid (1 mg/L) and ZnONPs (1–50 mg/L). The highest antioxidant and other activities with an enhanced rooting effect were noted in 25 mg/L ZnONP-treated callus. Similarly, the maximum metabolites were also accumulated in 25 mg/L ZnONP-treated callus. In both systems, the dose-dependent production of reactive oxygen species (ROS) was recorded, resulting in oxidative damage with a more pronounced toxic effect on in vitro cultures. Altogether, the results from this study constitute a first comprehensive view of the impact of ZnONPs on the oxidative stress and antioxidant responses in seedlings vs. in vitro cultures.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Biogenic Zinc Oxide Nanoparticles on Growth and Oxidative Stress Response in Flax Seedlings vs. In Vitro Cultures: A Comparative Analysis

et al. 2020

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“…Also, it has previously been observed that different concentrations of nanomaterials could have either a supportive or inhibitive impact on the growth and metabolic pathways of an organism. However, these studies, so far, have been investigated the case of plant cells 3‐5 . It has been reported that nanomaterials as abiotic factors activate the pathways related to the secondary metabolites production in plants.…”

Section: Introductionmentioning

confidence: 99%

“…However, these studies, so far, have been investigated the case of plant cells. [3][4][5] It has been reported that nanomaterials as abiotic factors activate the pathways related to the secondary metabolites production in plants.…”

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confidence: 99%

Effects of different graphene‐based nanomaterials as elicitors on growth and ganoderic acid production by Ganoderma lucidum

Rostami

Yazdian

Mirjani

et al. 2020

Biotechnology Progress

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Graphene-based nanomaterials (GBNs) have attracted considerable interest nowadays due to their wide range of applications. However, very little attention has been paid to the application of nanomaterials as potential elicitors for production of valuable metabolites. Herein, aiming to earn insight into effects of nanomaterials on secondary metabolite biosynthesis by medicinal fungi, we evaluated the influence of GBNs on growth and production of ganoderic acid (GA) by Ganoderma lucidum in submerged culture. Graphene oxide (GO), reduced graphene oxide (rGO), and rGO/Fe 3 O 4 nanocomposite were synthesized successfully and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy analysis. The prepared nanomaterials were added to the culture of G. lucidum at final concentrations of 50, 100, and 150 mg/L on Day 5. The results showed that the elicitation of G. lucidum with GO and rGO decreased the cell dry weight and GA production slightly, especially in higher concentrations. However, rGO/Fe 3 O 4 nanocomposite not negatively affected cell growth and improved GA production. G. lucidum growth rate responded to elicitation experiments differently and depended on the type of nanomaterials and their concentrations, but almost all GBNs caused an increase in GA content (mg/100 mg dry weight). Also, field emission scanning electron microscopy morphological study showed that under elicitation, mycelia were more condensed and tightly stacked together. The findings from this study may suggest that GBNs in low concentrations could be applied as elicitors to secondary metabolites production from higher fungus, but further environmental, physiological, and biological studies required.

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Nanoparticles as Elicitors of Biologically Active Ingredients in Plants

Anjum

Komal

Abbasi

et al. 2021

Nanotechnology in Plant Growth Promotion and Protection

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Advances in nanomaterials as novel elicitors of pharmacologically active plant specialized metabolites: current status and future outlooks

Abstract: Advancement in nanomaterials as novel elicitors of plant's specialized secondary metabolites.

Cited by 105 publications

References 118 publications

Effects of Biogenic Zinc Oxide Nanoparticles on Growth and Oxidative Stress Response in Flax Seedlings vs. In Vitro Cultures: A Comparative Analysis

Effects of Biogenic Zinc Oxide Nanoparticles on Growth and Oxidative Stress Response in Flax Seedlings vs. In Vitro Cultures: A Comparative Analysis

Effects of different graphene‐based nanomaterials as elicitors on growth and ganoderic acid production by Ganoderma lucidum

Nanoparticles as Elicitors of Biologically Active Ingredients in Plants

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