Advances in nanotechnology for improving the targeted delivery and activity of amphotericin B (2011–2023): a systematic review

Zadeh Mehrizi, Tahereh; Mosaffa, Nariman; Vodjgani, Mohammad; Ebrahimi Shahmabadi, Hasan

doi:10.1080/17435390.2024.2340467

Nanotoxicology

2024

DOI: 10.1080/17435390.2024.2340467

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Advances in nanotechnology for improving the targeted delivery and activity of amphotericin B (2011–2023): a systematic review

Tahereh Zadeh Mehrizi,

Nariman Mosaffa,

Mohammad Vodjgani

et al.

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Cited by 4 publications

References 148 publications

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Application of nanotechnology to improve the antileishmanial efficacy of amphotericin B

do Nascimento,

de Souza,

Ramos

et al. 2024

Journal of Drug Delivery Science and Technology

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Application of nanotechnology to improve the antileishmanial efficacy of amphotericin B

do Nascimento,

de Souza,

Ramos

et al. 2024

Journal of Drug Delivery Science and Technology

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Formulation Strategies to Overcome Amphotericin B Induced Toxicity

Dash,

Benival,

Jindal

2024

Mol. Pharmaceutics

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Fungal infection poses a major global threat to public health because of its wide prevalence, severe mortality rate, challenges involved in diagnosis and treatment, and the emergence of drugresistant fungal strains. Millions of people are getting affected by fungal infection, and around 3.8 million people face death per year due to fungal infection, as per the latest report. The polyene antibiotic AmB has an extensive record of use as a therapeutic moiety against systemic fungal infection and leishmaniasis since 1960. AmB has broad-spectrum fungistatic and fungicidal activity. AmB exerts its therapeutic activity at the cellular level by binding to fungal sterol and forming hydrophilic pores, releasing essential cellular components and ions into the extracellular fluid, leading to cell death. Despite using AmB as an antifungal and antileishmanial at a broad scale, its clinical use is limited due to drug-induced nephrotoxicity resulting from binding the aggregated form of the drug to mammalian sterol. To mitigate AmB-induced toxicity and to get better anti-fungal therapeutic outcomes, researchers have developed nanoformulations, self-assembled formulations, prodrugs, cholesterol-and albumin-based AmB formulations, AmB-mAb combination therapy, and AmB cochleates. These formulations have helped to reduce toxicity to a certain extent by controlling the aggregation state of AmB, providing sustained drug release, and altering the physicochemical and pharmacokinetic parameters of AmB. Although the preclinical outcome of AmB formulations is quite satisfactory, its parallel result at the clinical level is insignificant. However, the safety and efficacy of AmB therapy can be improved at the clinical stage by continuous investigation and collaboration among researchers, clinicians, and pharmaceutical companies.

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Enhancing Drug Solubility, Bioavailability, and Targeted Therapeutic Applications through Magnetic Nanoparticles

Zhuo,

Zhao,

Zhang

2024

Molecules

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Biological variability poses significant challenges in the development of effective therapeutics, particularly when it comes to drug solubility and bioavailability. Poor solubility across varying physiological conditions often leads to reduced absorption and inconsistent therapeutic outcomes. This review examines how nanotechnology, especially through the use of nanomaterials and magnetic nanoparticles, offers innovative solutions to enhance drug solubility and bioavailability. This comprehensive review focuses on recent advancements and approaches in nanotechnology. We highlight both the successes and remaining challenges in this field, emphasizing the role of continued innovation. Future research should prioritize developing universal therapeutic solutions, conducting interdisciplinary research, and leveraging personalized nanomedicine to address biological variability.

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Advances in nanotechnology for improving the targeted delivery and activity of amphotericin B (2011–2023): a systematic review

Cited by 4 publications

References 148 publications

Application of nanotechnology to improve the antileishmanial efficacy of amphotericin B

Application of nanotechnology to improve the antileishmanial efficacy of amphotericin B

Formulation Strategies to Overcome Amphotericin B Induced Toxicity

Enhancing Drug Solubility, Bioavailability, and Targeted Therapeutic Applications through Magnetic Nanoparticles

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