Advances in Nanotechnology towards Development of Silver Nanoparticle-Based Wound-Healing Agents

Nqakala, Zimkhitha B.; Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun; Meyer, Mervin; Onani, Martin O.; Madiehe, Abram Madimabe

doi:10.3390/ijms222011272

Cited by 80 publications

(46 citation statements)

References 121 publications

(315 reference statements)

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“…AgNPs have demonstrated unique properties compared to their bulk counterparts, and these have raised many concerns for biomedical application due to their ability to cross all cellular barriers and interact with important cellular organelles, such as the mitochondria and nucleus [7]. When inside cells, AgNPs can react with biomolecules, such as nucleic acids, proteins, enzymes, etc., resulting in dissolution and release of Ag + .…”

Section: In Vitro Cytotoxicity Of Ga-agnpsmentioning

confidence: 99%

“…To overcome these toxic effects, green synthesis methods, using natural products as reducing and stabilizing agents, were developed [6]. Green synthesis methods produce nanoparticles (NPs) using eco-friendly and non-toxic biological agents, such as microorganisms (e.g., bacteria, yeasts, fungi, and algae) and plant extracts as reducing and stabilizing agents [1,7,8]. Plantextract mediated green synthesis of NPs is often preferred over the microbial-mediated synthesis method due to the biohazards and laborious process associated with the latter [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Broad Spectrum Anti-Bacterial Activity and Non-Selective Toxicity of Gum Arabic Silver Nanoparticles

Fadaka

Meyer

Ahmed

et al. 2022

IJMS

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Silver nanoparticles (AgNPs) are the most commercialized nanomaterials and presumed to be biocompatible based on the biological effects of the bulk material. However, their physico-chemical properties differ significantly to the bulk materials and are associated with unique biological properties. The study investigated the antimicrobial and cytotoxicity effects of AgNPs synthesized using gum arabic (GA), sodium borohydride (NaBH4), and their combination as reducing agents. The AgNPs were characterized using ultraviolet-visible spectrophotometry (UV-Vis), dynamic light scattering (DLS), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FT-IR). The anti-bacterial activity was assessed using agar well diffusion and microdilution assays, and the cytotoxicity effects on Caco-2, HT-29 and KMST-6 cells using MTT assay. The GA-synthesized AgNPs (GA-AgNPs) demonstrated higher bactericidal activity against all bacteria, and non-selective cytotoxicity towards normal and cancer cells. AgNPs reduced by NaBH4 (C-AgNPs) and the combination of GA and NaBH4 (GAC-AgNPs) had insignificant anti-bacterial activity and cytotoxicity at ≥50 µg/mL. The study showed that despite the notion that AgNPs are safe and biocompatible, their toxicity cannot be overruled and that their toxicity can be channeled by using biocompatible polymers, thereby providing a therapeutic window at concentrations that are least harmful to mammalian cells but toxic to bacteria.

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Section: In Vitro Cytotoxicity Of Ga-agnpsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Broad Spectrum Anti-Bacterial Activity and Non-Selective Toxicity of Gum Arabic Silver Nanoparticles

Fadaka

Meyer

Ahmed

et al. 2022

IJMS

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“…However, all these methods are not only costly, but were also reported to produce products that might be harmful to humans and the environment. The methods are discussed in detail elsewhere [74,77,102].…”

Section: Plant-synthesized Agnps For Treatment Of Dental Diseasesmentioning

confidence: 99%

Plant Extract-Synthesized Silver Nanoparticles for Application in Dental Therapy

et al. 2022

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Oral diseases are the most common non-communicable diseases in the world, with dental caries and periodontitis causing major health and social problems. These diseases can progress to systematic diseases and cause disfigurement when left untreated. However, treatment of oral diseases is among the most expensive treatments and often focus on restoration of form and function. Caries prevention has traditionally relied on oral hygiene and diet control, among other preventive measures. In this paper, these measures are not disqualified but are brought into a new context through the use of nanotechnology-based materials to improve these conventional therapeutic and preventive measures. Among inorganic nanomaterials, silver nanoparticles (AgNPs) have shown promising outcomes in dental therapy, due to their unique physicochemical properties and enhanced anti-bacterial activities. As such, AgNPs may provide newer strategies for treatment and prevention of dental infections. However, numerous concerns around the chemical synthesis of nanomaterials, which are not limited to cost and use of toxic reducing agents, have been raised. This has inspired the green synthesis route, which uses natural products as reducing agents. The biogenic AgNPs were reported to be biocompatible and environmentally friendly when compared to the chemically-synthesized AgNPs. As such, plant-synthesized AgNPs can be used as antimicrobial, antifouling, and remineralizing agents for management and treatment of dental infections and diseases.

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“…This nanomaterial has been extensively studied and used in medicine for decades. Due to their activities, AgNPs with antimicrobial properties were approved by the FDA for wound therapy [196,197]. Currently, there are nine ongoing clinical trials investigating AgNPs as an antibacterial therapy in different diseases.…”

Section: Nanocarriers In Clinical Trialsmentioning

confidence: 99%

Nanotechnology-Based Delivery Systems for Antimicrobial Peptides

et al. 2021

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Antimicrobial resistance (AMR) is a significant threat to global health. The conventional antibiotic pool has been depleted, forcing the investigation of novel and alternative antimicrobial strategies. Antimicrobial peptides (AMPs) have shown potential as alternative diagnostic and therapeutic agents in biomedical applications. To date, over 3000 AMPs have been identified, but only a fraction of these have been approved for clinical trials. Their clinical applications are limited to topical application due to their systemic toxicity, susceptibility to protease degradation, short half-life, and rapid renal clearance. To circumvent these challenges and improve AMP’s efficacy, different approaches such as peptide chemical modifications and the development of AMP delivery systems have been employed. Nanomaterials have been shown to improve the activity of antimicrobial drugs by providing support and synergistic effect against pathogenic microbes. This paper describes the role of nanotechnology in the targeted delivery of AMPs, and some of the nano-based delivery strategies for AMPs are discussed with a clear focus on metallic nanoparticle (MNP) formulations.

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Advances in Nanotechnology towards Development of Silver Nanoparticle-Based Wound-Healing Agents

Cited by 80 publications

References 121 publications

Broad Spectrum Anti-Bacterial Activity and Non-Selective Toxicity of Gum Arabic Silver Nanoparticles

Broad Spectrum Anti-Bacterial Activity and Non-Selective Toxicity of Gum Arabic Silver Nanoparticles

Plant Extract-Synthesized Silver Nanoparticles for Application in Dental Therapy

Nanotechnology-Based Delivery Systems for Antimicrobial Peptides

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