Advances in passively driven microfluidics and lab-on-chip devices: a comprehensive literature review and patent analysis

Narayanamurthy, Vigneswaran; Jeroish, Z. E.; Bhuvaneshwari, K.; Bayat, Pouriya; Premkumar, R.; Samsuri, Fahmi; Yusoff, Mashitah M.

doi:10.1039/d0ra00263a

Cited by 152 publications

(101 citation statements)

References 224 publications

(217 reference statements)

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“…On the other hand, passive microfluidics is other typical and well-known method used for driving fluids [ 95 ]. This method has also been used for printed circuit boards to develop high-performance PCB-based capillary pumps for affordable point-of-care diagnostics [ 96 , 97 ].…”

Section: Other Methodsmentioning

confidence: 99%

Lab-on-PCB and Flow Driving: A Critical Review

Perdigones

2021

Micromachines

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Lab-on-PCB devices have been developed for many biomedical and biochemical applications. However, much work has to be done towards commercial applications. Even so, the research on devices of this kind is rapidly increasing. The reason for this lies in the great potential of lab-on-PCB devices to provide marketable devices. This review describes the active flow driving methods for lab-on-PCB devices, while commenting on their main characteristics. Among others, the methods described are the typical external impulsion devices, that is, syringe or peristaltic pumps; pressurized microchambers for precise displacement of liquid samples; electrowetting on dielectrics; and electroosmotic and phase-change-based flow driving, to name a few. In general, there is not a perfect method because all of them have drawbacks. The main problems with regard to marketable devices are the complex fabrication processes, the integration of many materials, the sealing process, and the use of many facilities for the PCB-chips. The larger the numbers of integrated sensors and actuators in the PCB-chip, the more complex the fabrication. In addition, the flow driving-integrated devices increase that difficulty. Moreover, the biological applications are demanding. They require transparency, biocompatibility, and specific ambient conditions. All the problems have to be solved when trying to reach repetitiveness and reliability, for both the fabrication process and the working of the lab-on-PCB, including the flow driving system.

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Section: Other Methodsmentioning

confidence: 99%

Lab-on-PCB and Flow Driving: A Critical Review

Perdigones

2021

Micromachines

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“…39,40 Another factor that has led to the use of lab-on-chips devices in recent years is the use of small amounts of uid in these chips, which reduces costs and time of process. 42,43 Also, the accuracy of these chips is very high. Because it is a continuous process and the operator is not involved in them, it causes less pollution to enter them and drastically reduces human errors due to high accuracy.…”

Section: Microfluidicsmentioning

confidence: 99%

Microfluidics for core–shell drug carrier particles – a review

et al. 2021

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“…On the other hand, the device’s physical configuration defines the system’s functionality in passive microfluidics. This device operates by the working fluid’s surface effects, such as surface tension, osmosis, pressure, capillary action, gravity-driven flow, vacuums, hydrostatic flow, and selective hydrophobic/hydrophilic control [ 29 ]. The structural complexity of the passive devices is relatively higher compared to the active device.…”

Section: Introductionmentioning

confidence: 99%

Heater Integrated Lab-on-a-Chip Device for Rapid HLA Alleles Amplification towards Prevention of Drug Hypersensitivity

Uddin

Sayad

Chan

et al. 2021

Sensors

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HLA-B*15:02 screening before administering carbamazepine is recommended to prevent life-threatening hypersensitivity. However, the unavailability of a point-of-care device impedes this screening process. Our research group previously developed a two-step HLA-B*15:02 detection technique utilizing loop-mediated isothermal amplification (LAMP) on the tube, which requires two-stage device development to translate into a portable platform. Here, we report a heater-integrated lab-on-a-chip device for the LAMP amplification, which can rapidly detect HLA-B alleles colorimetrically. A gold-patterned micro-sized heater was integrated into a 3D-printed chip, allowing microfluidic pumping, valving, and incubation. The performance of the chip was tested with color dye. Then LAMP assay was conducted with human genomic DNA samples of known HLA-B genotypes in the LAMP-chip parallel with the tube assay. The LAMP-on-chip results showed a complete match with the LAMP-on-tube assay, demonstrating the detection system’s concurrence.

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Advances in passively driven microfluidics and lab-on-chip devices: a comprehensive literature review and patent analysis

Abstract: Different approaches employed in the passively driven microfluidics and LOC devices.

Cited by 152 publications

References 224 publications

Lab-on-PCB and Flow Driving: A Critical Review

Lab-on-PCB and Flow Driving: A Critical Review

Microfluidics for core–shell drug carrier particles – a review

Heater Integrated Lab-on-a-Chip Device for Rapid HLA Alleles Amplification towards Prevention of Drug Hypersensitivity

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