Advances in Preparation and Properties of Regenerated Silk Fibroin

Huang, Linlin; Shi, Jifeng; Zhou, Wei; Zhang, Qing

doi:10.3390/ijms241713153

Cited by 15 publications

(2 citation statements)

References 189 publications

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“…(Figure 1). In addition, the preparation methods are also varied and selected according to the different forms of SF or specific requirements [83,84]. Its exceptional mechanical properties, good biocompatibility, simple loading process, and flexibility in modification and processing have made SF an excellent nanomaterial candidate for drug delivery using nanomaterials.…”

Section: Sf Np Delivery Systemmentioning

confidence: 99%

Applications and Potentials of a Silk Fibroin Nanoparticle Delivery System in Animal Husbandry

Guo,

Awais,

Fei

et al. 2024

Animals

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Silk fibroin (SF), a unique natural polymeric fibrous protein extracted from Bombyx mori cocoons, accounts for approximately 75% of the total mass of silk. It has great application prospects due to its outstanding biocompatibility, biodegradability, low immunogenicity, and mechanical stability. Additionally, it is non-toxic and environmentally friendly. Nanoparticle delivery systems constructed with SF can improve the bioavailability of the carriers, increase the loading rates, control the release behavior of the deliverables, and enhance their action efficiencies. Animal husbandry is an integral part of agriculture and plays a vital role in the development of the rural economy. However, the pillar industry experiences a lot of difficulties, like drug abuse while treating major animal diseases, and serious environmental pollution, restricting sustainable development. Interestingly, the limited use cases of silk fibroin nanoparticle (SF NP) delivery systems in animal husbandry, such as veterinary vaccines and feed additives, have shown great promise. This paper first reviews the SF NP delivery system with regard to its advantages, disadvantages, and applications. Moreover, we describe the application status and developmental prospects of SF NP delivery systems to provide theoretical references for further development in livestock production and promote the high-quality and healthy development of animal husbandry.

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Section: Sf Np Delivery Systemmentioning

confidence: 99%

Applications and Potentials of a Silk Fibroin Nanoparticle Delivery System in Animal Husbandry

Guo,

Awais,

Fei

et al. 2024

Animals

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“…Further centrifugation is performed to remove insoluble substances, at which point the solution obtained is a pure RSF solution. The solution can be further subjected to use, such as electrostatic spinning and freeze-drying to achieve a variety of nanoscale products [38]. These methods make it easy to produce nanoscale fibers with excellent yield.…”

Section: Introductionmentioning

confidence: 99%

A Simplified Method for the Preparation of Highly Conductive and Flexible Silk Nanofibrils/MXene Membrane

Ding,

Teng,

Wang

et al. 2023

Materials

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Silk nanofibers (SNF) have great applications in high-performance functional nanocomposites due to their excellent mechanical properties, biocompatibility, and degradability. However, the preparation of SNF by traditional methods often requires the use of some environmentally harmful or toxic reagents, limiting its application in green chemistry. In this paper, we successfully prepared SNF using natural silk as raw material and solvent stripping technology by adjusting the solvent concentration and solution ratio (the diameter of about 120 nm). Using the above SNFs as raw materials, SNF membranes were prepared by vacuum filtration technology. In addition, we prepared an SNF/MXene nanocomposite material with excellent humidity sensitivity by simply coating MXene nanosheets with silk fibers. The conductivity of the material can approach 1400.6 S m−1 with excellent mechanical strength (51.34 MPa). The SNF/MXene nanocomposite material with high mechanical properties, high conductivity, and green degradability can be potentially applied in the field of electromagnetic interference (EMI) shielding, providing a feasible approach for the development of functional nanocomposite materials.

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Current Progress on Scale‐Up and Commercialization of Microbially‐Produced Silk

Breslauer

2024

Adv Funct Materials

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Over the past two decades, significant advancements have been made in the scalable production and commercialization of microbially‐produced recombinant protein polymers. This perspective presents the evolution from early research efforts to the development of market‐ready products, with a focus on recombinant silk‐like proteins. Initial attempts to synthesize spider silk proteins in microbial hosts faced challenges with solubility, stability, and yield. Recent advancements in synthetic biology, protein engineering, and bioprocess development have enabled the substantial progress on these challenges. Early commercial efforts highlight the complexities and high costs involved in silk production and more recent strategies have shifted toward processes with better scalability, techno‐economics, and product properties. Significant commercial progress has been made, with products launched in textiles and personal care. Although market penetration is limited so far, substantial groundwork is laid for future success. Key challenges remain, such as continued high production costs and the need for cost‐effective purification and fiber spinning techniques. However, the convergence of scientific, technological, and market developments –including a growing number of product launches – suggests that recombinant silk and protein polymers can soon become widespread sustainable materials across various industries.

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Advances in Preparation and Properties of Regenerated Silk Fibroin

Cited by 15 publications

References 189 publications

Applications and Potentials of a Silk Fibroin Nanoparticle Delivery System in Animal Husbandry

Applications and Potentials of a Silk Fibroin Nanoparticle Delivery System in Animal Husbandry

A Simplified Method for the Preparation of Highly Conductive and Flexible Silk Nanofibrils/MXene Membrane

Current Progress on Scale‐Up and Commercialization of Microbially‐Produced Silk

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