Advances in process chromatography and applications in the food, beverage and nutraceutical industries

Ottens, Marcel; Chilamkurthi, Sreekanth

doi:10.1533/9780857090751.1.109

Cited by 4 publications

(3 citation statements)

References 141 publications

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“…Such valorization could pay off costs of technology like ion chromatography in the purification process. Chromatography is used for beer stabilization through the removal of the phenolic compounds, at price similar to membrane filtration processes [38]. Membrane filtration cost has been evaluated at laboratory scale, and indicated that the production price would be about 0.7D /kg of xylans [39], which would correspond to 21D /ton of treated corn stover according to previous data [29].…”

Section: Concentration and Purificationmentioning

confidence: 89%

Performance evaluation of a semi-industrial production process of arabinoxylans from wheat bran

Jacquemin

Mogni

Zeitoun

et al. 2015

Process Biochemistry

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a b s t r a c tA process for hemicellulose fractionation and purification from wheat straw and bran has been investigated. The aim was to define the efficiency of a pilot scale process combining twin-screw extrusion and refining steps such as ultrafiltration and chromatography, to replace alcoholic precipitation.Extraction by twin-screw extrusion gave a complex extract containing only 22.7% carbohydrates. Evaporation (EV) followed by ethanol precipitation (P) and freeze-drying (FD), gave a 25.7% arabinoxylan yield with 24.1% arabinoxylan content. The other purification process studied was based on a combination of ultrafiltration (UF), anion exchange chromatography (CHR) and freeze-drying (FD), without precipitation. It gave a 24.3% yield of arabinoxylans into the hemicellulosic powders and 13.9% arabinoxylan content. Despite the obvious interest of using ultrafiltration for demineralization and anion exchange chromatography for decoloration, the purity of the final powder is still too low, because of difficulties in achieving separation of proteins and hemicelluloses and concentration of the solution, in the same step.

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Section: Concentration and Purificationmentioning

confidence: 89%

Performance evaluation of a semi-industrial production process of arabinoxylans from wheat bran

Jacquemin

Mogni

Zeitoun

et al. 2015

Process Biochemistry

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“…This approach enables the recovery of all mixture components with similar charges. Ottens and coworkers [1] stressed that an IEC procedure is required for the preparative purification of biomolecules, and that the resins and adsorbents used must be chosen carefully. The major stages in the IEC process are the adhesion and liberation of species of interest.…”

Section: Introductionmentioning

confidence: 99%

Separation and Purification of Bioactive Molecules by Ion Exchange

Alam¹

2023

Ion Exchange Resins

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Bioactive molecules (or signaling molecules) are involved in tissue regeneration and have an important role in modulating the microenvironment in vivo. Bioactive chemicals have the ability to govern host cell motility, proliferation, and differentiation, as well as enabling cells to interact with their surrounding microenvironment via particular receptors for chemical recognition. This chapter introduces ion-exchange chromatography (IEC) as a method for separating and purifying bioactive compounds such as polyphenols, catechin derivatives from complicated plant mixtures, proteins, minor whey protein, peptides, human C-peptide, alkaloids from Chinese medicines, plasmid DNA and carbohydrates.

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“…It has orders of magnitude higher interfacial area per unit volume for separation, resulting in a compact processing volume and lower solvent usage. It is also less prone to fouling than membrane filtration, and the separation can be achieved with mild operating conditions, which makes chromatography suitable for the separation of many fragile compounds, such as proteins [1].…”

Section: Introductionmentioning

confidence: 99%

Speedy standing wave design, optimization, and scaling rules of simulated moving bed systems with linear isotherms

Weeden

Wang

2017

Journal of Chromatography A

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Simulated Moving Bed (SMB) systems with linear adsorption isotherms have been used for many different separations, including large-scale sugar separations. While SMBs are much more efficient than batch operations, they are not widely used for large-scale production because there are two key barriers. The methods for design, optimization, and scale-up are complex for non-ideal systems. The Speedy Standing Wave Design (SSWD) is developed here to reduce these barriers. The productivity (P) and the solvent efficiency (F/D) are explicitly related to seven material properties and 13 design parameters. For diffusion-controlled systems, the maximum P or F/D is controlled by two key dimensionless material properties, the selectivity (α) and the effective diffusivity ratio (η), and two key dimensionless design parameters, the ratios of step time/diffusion time and pressure-limited convection time/diffusion time. The optimum column configuration for maximum P or F/D is controlled by the weighted diffusivity ratio (η/α). In general, high α and low η/α favor high P and F/D. The productivity is proportional to the ratio of the feed concentration to the diffusion time. Small particles and high diffusivities favor high productivity, but do not affect solvent efficiency. Simple scaling rules are derived from the two key dimensionless design parameters. The separation of acetic acid from glucose in biomass hydrolysate is used as an example to show how the productivity and the solvent efficiency are affected by the key dimensionless material and design parameters. Ten design parameters are optimized for maximum P or minimum cost in one minute on a laptop computer. If the material properties are the same for different particle sizes and the dimensionless groups are kept constant, then lab-scale testing consumes less materials and can be done four times faster using particles with half the particle size.

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Advances in process chromatography and applications in the food, beverage and nutraceutical industries

Cited by 4 publications

References 141 publications

Performance evaluation of a semi-industrial production process of arabinoxylans from wheat bran

Performance evaluation of a semi-industrial production process of arabinoxylans from wheat bran

Separation and Purification of Bioactive Molecules by Ion Exchange

Speedy standing wave design, optimization, and scaling rules of simulated moving bed systems with linear isotherms

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