Advances in production and structural derivatization of the promising molecule ursolic acid

Liu, Haoran; Ahmad, Nadeem; Lv, Bo; Li, Chun

doi:10.1002/biot.202000657

Cited by 13 publications

(4 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The switch of traditional chemical manufacturing towards green biological manufacturing supersedes the existing “high energy consumption, high emissions” model and dependence on fossil resources (Clark et al, 2012) for the synthesis of valuable compounds. For example, enzyme catalysis and construction of microbial cell factories to biosynthesize Glycyrrhetinic acid (Ahmad et al, 2020; Xu et al, 2021), Diosgenin (Abbas et al, 2021), Ursolic acid and its derivatives (Liu et al, 2021). In addition, employing renewable biomaterials with low CO 2 emission to replace fossil fuel resources has become the global attention to develop green, renewable, safe, and controllable biological manufacturing as a primary goal of human society.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in yeast genome evolution with stress tolerance for green biological manufacturing

Zhang

Guo

et al. 2022

Biotech & Bioengineering

Self Cite

View full text Add to dashboard Cite

Green biological manufacturing is a revolutionary industrial model utilizing yeast as a significant microbial cell factory to produce biofuels and other biochemicals. However, biotransformation efficiency is often limited owing to several stress factors resulting from environmental changes or metabolic imbalance, leading to the slow growth of cells, compromised yield, and enhanced energy consumption. These factors make biological manufacturing competitively less economical. In this regard, minimizing the stress impact on microbial cell factories and strong robust performance have been an interesting area of interest in the last few decades. In this review, we focused on revealing the stress factors and their associated mechanisms for yeast in biological manufacturing. To improve yeast tolerance, rational and irrational strategies were introduced, and the molecular basis of genome evolution in yeast was also summarized. Furthermore, strategies of genome‐directed evolution such as homology directed repair and nonhomologous end‐joining, and the synthetic chromosome recombination and modification by LoxP‐mediated evolution and their association with stress tolerance was highlighted. We hope that genome evolution provides new insights for solving the limitations of the natural phenotypes of microorganisms in industrial fermentation for the production of valuable compounds.

show abstract

Section: Introductionmentioning

confidence: 99%

Recent advances in yeast genome evolution with stress tolerance for green biological manufacturing

Zhang

Guo

et al. 2022

Biotech & Bioengineering

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ursolic acid is widely used as an anti-inflammatory drug, and many biological experiments have demonstrated that ursolic acid can play an anti-inflammatory role in a variety of diseases, including both oncological and non-oncological diseases [36,37]. Clinical trials are now being carried out to verify its efficacy and safety [38].…”

Section: Discussionmentioning

confidence: 99%

Ursolic Acid Alleviates Neuroinflammation after Intracerebral Hemorrhage by Mediating Microglial Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway

Lei,

Li,

Hua

et al. 2023

IJMS

View full text Add to dashboard Cite

The neuroinflammatory response after intracerebral hemorrhage (ICH) causes a large amount of neuronal loss, and inhibiting the inflammatory response can improve the prognosis. In previous laboratory studies and clinical trials, ursolic acid (UA) inhibited the inflammatory response, but whether it can be administered to inhibit the neuroinflammatory response after cerebral hemorrhage is unknown. The aim of this study was to investigate the effects of ursolic acid after cerebral hemorrhage. Online databases were used to obtain potential therapeutic targets of ursolic acid for the treatment of cerebral hemorrhage, and possible mechanisms were analyzed by KEGG, GO, and molecular docking. A rat model of cerebral hemorrhage was established using collagenase, and an in vitro cerebral hemorrhage model was constructed by adding hemin to BV2 cell culture medium. Enzyme-linked immunosorbent assay (ELISA), Western blotting (WB), immunofluorescence, TUNEL staining, and calcein/PI staining were used to investigate the degree of microglial M1 polarization, changes in the levels of inflammatory factors, activation of the NF-κB pathway, and changes in the indicators of cellular death after ursolic acid treatment. In addition, phorbol 12-myristate 13-acetate (PMA) was used to activate the NF-κB pathway to verify that ursolic acid exerts its anti-neuroinflammatory effects by regulating the NF-κB/NLRP3/GSDMD pathway. Network pharmacology and bioinformatics analyses revealed that ursolic acid may exert its therapeutic effects on cerebral hemorrhage through multiple pathways. Together, in vivo and in vitro experiments showed that ursolic acid inhibited microglial M1 polarization and significantly reduced the levels of p-NF-κB, GSDMD-N, cleaved caspase-1, TNF-α, IL-6, and IL-1β, which were significantly inhibited by the use of PMA. Ursolic acid inhibits microglial pyroptosis via the NF-κB/NLRP3/GSDMD pathway to alleviate neuroinflammatory responses after cerebral hemorrhage.

show abstract

“…Moreover, it should be noted that antimicrobial surface agents can inhibit biofilm formation for example via quorum sensing [77] or cyclic di-GMP (c-di-GMP) signaling interference, of which the latter is an intracellular signaling molecule of bacteria [78]. Quorum sensing (QS) is an intra-and intercellular mechanism, which facilitates the communication between cells and the interaction between the environment and cells [79].…”

Section: Antimicrobial Stainless Steel Surfacesmentioning

confidence: 99%

Bacterial Attachment and Biofilm Formation on Antimicrobial Sealants and Stainless Steel Surfaces

Ciolacu

Zand

Negrau

et al. 2022

Foods

View full text Add to dashboard Cite

Biofilms are highly resistant to external forces, especially chemicals. Hence, alternative control strategies, like antimicrobial substances, are forced. Antimicrobial surfaces can inhibit and reduce microbial adhesion to surfaces, preventing biofilm formation. Thus, this research aimed to investigate the bacterial attachment and biofilm formation on different sealants and stainless steel (SS) surfaces with or without antimicrobials on two Gram-positive biofilm forming bacterial strains. Antimicrobial surfaces were either incorporated or coated with anti-microbial, -fungal or/and bactericidal agents. Attachment (after 3 h) and early-stage biofilm formation (after 48 h) of Staphylococcus capitis (S. capitis) and Microbacterium lacticum (M. lacticum) onto different surfaces were assessed using the plate count method. In general, bacterial adhesion on sealants was lower compared to adhesion on SS, for surfaces with and without antimicrobials. Antimicrobial coatings on SS surfaces played a role in reducing early-stage biofilm formation for S. capitis, however, no effects were observed for M. lacticum. S. capitis adhesion and biofilm formation were reduced by 8% and 25%, respectively, on SS coated with an antimicrobial substance (SS_4_M), compared to the same surface without the antimicrobial coating (SS_4_control). Incorporation of both antifungicidal and bactericidal agents (S_5_FB) significantly reduced (p ≤ 0.05) early-stage biofilm formation of M. lacticum, compared to the other sealants incoportating either solely antifungal agents (S_2_F) or no active compound (S_control). Furthermore, the thickness of the coating layer correlated weakly with the antimicrobial effect. Hence, equipment manufacturers and food producers should carefully select antimicrobial surfaces as their effects on bacterial adhesion and early-stage biofilm formation depend on the active agent and bacterial species.

show abstract

Advances in production and structural derivatization of the promising molecule ursolic acid

Cited by 13 publications

References 114 publications

Recent advances in yeast genome evolution with stress tolerance for green biological manufacturing

Recent advances in yeast genome evolution with stress tolerance for green biological manufacturing

Ursolic Acid Alleviates Neuroinflammation after Intracerebral Hemorrhage by Mediating Microglial Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway

Bacterial Attachment and Biofilm Formation on Antimicrobial Sealants and Stainless Steel Surfaces

Contact Info

Product

Resources

About