Advances in recurrence and malignant transformation of sinonasal inverted papillomas

Abstract

Abstract. Sinonasal inverted papilloma (SIP) is a benign tumor of the nasal cavity and sinus. SIP is characterized by aggressive malignant transformation and a high rate of recurrence. Inadequate removal of the tumor during surgery is one of the most significant contributors to SIP recurrence. A growing body of evidence suggests that molecular alteration in SIP, including human papilloma virus infections, single nucleotide polymorphisms of key genes, deregulation of signaling pathways and immunological changes, may lead to SIP occurrence and malignant transformation. However, the extent to which these molecular mechanisms contribute to SIP pathology and transformation remains unclear due to limited research. Further studies are warranted to elucidate the primary dependent factors that contribute to SIP etiology. The present article reviewed risk factors of progression and recurrence of SIP, including outdoor and industrial occupational exposure, smoking, septal deviation, SIP location, recurrent cases, stage of SIP-associated squamous cell carcinoma and choice of surgical method.

Comprehensive analysis of HPV infection, EGFR exon 20 mutations and LINE1 hypomethylation as risk factors for malignant transformation of sinonasal‐inverted papilloma to squamous cell carcinoma

“…The aetiology of ISPs and OSPs is not fully understood, although several studies have suggested that HPV infection, bacterial infections and tobacco smoking may be risk factors . Moreover, a recent case–control study found a significantly increased risk among subjects previously exposed to organic solvents, welding fumes and nickel compounds, extending previous observations indicating an unusually high proportion of cases in those employed in the steel industry and in manufacturing .…”

Imaging of sino-nasal inverted papilloma: How can we emphasize the usefulness of the “striated pattern” sign?

“…Inverted papillomas (IPs), though being an uncommon benign epithelial neoplasm, have generated considerable interest through literature. This interest is that though they are benign, they are locally aggressive and have a propensity to recur, and are sometimes associated with malignancy [1,2] Recurrent disease and metachronous carcinoma can even develop after a prolonged period of time. The term papilloma means neoplasia with epithelial growth, while the US National Cancer Institute's had defined inverting papilloma as a type of tumor in which surface epithelial cells grow downward into the underlying connective tissue, and thus have been coined the term (inverting = inverted) [3].…”

Sinonasal Squamous Papilloma with Orbital Infiltration in an Elderly Nigerian Female, Unusual Presentation of an Uncommon Tumor: A Case Report

“…Imaging also aids in the determination of tumour margins and attachment sites, and a combination of computed tomography (CT) scan, magnetic resonance imaging (MRI) and positron emission tomography. (PET/CT), could be carried out [16]. The CT scan of the paranasal sinuses and orbits, which is the most preferred radiological imaging, was carried out in the patient.…”