Advances in regulating physicochemical properties of mesoporous silica nanocarriers to overcome biological barriers

Wang, Yumei; Gou, Kaijun; Guo, Xianmou; Ke, Jia; Li, Sanming; Li, Heran

doi:10.1016/j.actbio.2021.01.005

Cited by 42 publications

(16 citation statements)

References 196 publications

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“…Cancer therapy efficacy can be effectively improved by the assistance of nano-drug delivery systems (nano-DDSs) with a specific interaction to tumor cells and intelligent stimulus-triggered drug delivery performance in a tumor microenvironment (TME). Mesoporous silica nanoparticles (MSNs) with a diverse morphology, a stable rigid framework, an ordered mesoporous structure, a large surface area, and a controllable particle size are considered to be suitable drug delivery platforms . Along with the great advances in self-assembly strategies and structure control, researchers begin to focus on adjusting the morphological characteristics and multifunctional design of MSNs to acquire favorable biological functions. , Over the past decade, chiral MSNs (CMSs, characterized as MSNs with molecular or macroscopic helical structures) have attracted much attention in the biomedical fields.…”

Section: Introductionmentioning

confidence: 99%

pH/H₂O₂ Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy

Wang

Gou

et al. 2021

ACS Appl. Mater. Interfaces

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Nano-drug delivery systems (nano-DDSs) with an existing specific interaction to tumor cells and intelligent stimulus-triggered drug delivery performance in a tumor microenvironment (TME) remain hotspots for effective cancer therapy. Herein, multifunctional pH/H2O2 dual-responsive chiral mesoporous silica nanorods (HA-CD/DOX-PCMSRs) were creatively constructed by first grafting phenylboronic acid pinacol ester (PBAP) onto the amino-functioned nanorods, then incorporating doxorubicin (DOX) into the mesoporous structure, and finally coating with the cyclodextrin-modified hyaluronic acid conjugate (HA-CD) through a weak host–guest interaction. Under a physiological environment, the gatekeeper CD could avoid the premature leakage of DOX and minimize the side effects to normal cells. After the uptake by the tumor cells, the H2O2-sensitive moieties of PBAP were exposed and a small amount of DOX was leaked along with the shift of the supramolecular switch HA-CD under the acidic condition. Notably, the self-supplying H2O2 mediated by the released DOX in turn accelerated the PBAP disintegration, further promoted the rapid release of DOX, and increased the DOX accumulation in tumor regions. Innovatively, this nano-DDS could simultaneously achieve the tumor-targeting ability via CD44 receptor-mediated endocytosis and pH/H2O2 dual responsiveness activated by the TME and hence exhibited superior antitumor efficacy. Furthermore, HA acting as the hydrophilic shell could improve the biocompatibility of this nano-DDS.

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Section: Introductionmentioning

confidence: 99%

pH/H₂O₂ Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy

Wang

Gou

et al. 2021

ACS Appl. Mater. Interfaces

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“…Biomimetic therapeutics and enhancement of surface hydrophilicity by PEGylation could be used to improve the biocompatibility and safety profile of MSN. 214 An amalgamation of targeting attributes, controlled release, and safety considerations could result in utilizing the virtues of MSN to its fullest potential. Researchers in the field could apply these various approaches to address the identified problems to expedite translation from lab to the bedside.…”

Section: Discussionmentioning

confidence: 99%

Tuning Mesoporous Silica Nanoparticles in Novel Avenues of Cancer Therapy

et al. 2022

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The global menace of cancer has led to an increased death toll in recent years. The constant evolution of cancer therapeutics with novel delivery systems has paved the way for translation of innovative therapeutics from bench to bedside. This review explains the significance of mesoporous silica nanoparticles (MSNs) as delivery vehicles with particular emphasis on cancer therapy, including novel opportunities for biomimetic therapeutics and vaccine delivery. Parameters governing MSN synthesis, therapeutic agent loading characteristics, along with tuning of MSN toward cancer cell specificity have been explained. The advent of MSN in nanotheranostics and its potential in forming nanocomposites for imaging purposes have been illustrated. Additionally, various hurdles encountered during the bench to bedside translation have been explained along with potential avenues to circumvent them. This also opens up new horizons in drug delivery, which could be useful to researchers in the years to come.

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“…The geometric shape is also known to affect cellular uptake, in vivo fate and hemorheological dynamics of nanoparticles. The surface charge of nanoparticles also affects the biodistribution and blood circulation time whereas the chemical composition, biocompatibility, size, and surface properties of nanoparticles may impact cellular uptake [ 261 ]. It has been demonstrated that a resistance to deformation or particle rigidity also affects cellular uptake and efficacy of treatment [ 262 ].…”

Section: Improving Drug Delivery Through Use Of Nanoprecision Toolsmentioning

confidence: 99%

Recent Advances in Endocannabinoid System Targeting for Improved Specificity: Strategic Approaches to Targeted Drug Delivery

Dasram

Walker

Khamanga

2022

IJMS

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Opportunities for developing innovative and intelligent drug delivery technologies by targeting the endocannabinoid system are becoming more apparent. This review provides an overview of strategies to develop targeted drug delivery using the endocannabinoid system (ECS). Recent advances in endocannabinoid system targeting showcase enhanced pharmaceutical therapy specificity while minimizing undesirable side effects and overcoming formulation challenges associated with cannabinoids. This review identifies advances in targeted drug delivery technologies that may permit access to the full pharmacotherapeutic potential of the ECS. The design of optimized nanocarriers that target specific tissues can be improved by understanding the nature of the signaling pathways, distribution in the mammalian body, receptor structure, and enzymatic degradation of the ECS. A closer look at ligand-receptor complexes, endocannabinoid tone, tissue distribution, and G-protein activity leads to a better understanding of the potential of the ECS toolkit for therapeutics. The signal transduction pathways examine the modulation of downstream effector proteins, desensitization, signaling cascades, and biased signaling. An in-depth and overall view of the targeted system is achieved through homology modeling where mutagenesis and ligand binding examine the binding site and allow sequence analysis and the formation of libraries for molecular docking and molecular dynamic simulations. Internalization routes exploring receptor-mediated endocytosis and lipid rafts are also considered for explicit signaling. Furthermore, the review highlights nanotechnology and surface modification aspects as a possible future approach for specific targeting.

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Advances in regulating physicochemical properties of mesoporous silica nanocarriers to overcome biological barriers

Cited by 42 publications

References 196 publications

pH/H₂O₂ Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy

pH/H₂O₂ Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy

Tuning Mesoporous Silica Nanoparticles in Novel Avenues of Cancer Therapy

Recent Advances in Endocannabinoid System Targeting for Improved Specificity: Strategic Approaches to Targeted Drug Delivery

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Advances in regulating physicochemical properties of mesoporous silica nanocarriers to overcome biological barriers

Cited by 42 publications

References 196 publications

pH/H2O2 Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy

pH/H2O2 Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy

Tuning Mesoporous Silica Nanoparticles in Novel Avenues of Cancer Therapy

Recent Advances in Endocannabinoid System Targeting for Improved Specificity: Strategic Approaches to Targeted Drug Delivery

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pH/H₂O₂ Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy

pH/H₂O₂ Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy