Advances in relationship between cell senescence and atherosclerosis

LIU, Dekun; LIU, Jiali; Zhang, Dan; Yang, Wenqing

doi:10.3724/zdxbyxb-2021-0270

Cited by 4 publications

(4 citation statements)

References 109 publications

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“…Notably, GLP is anti-aging by scavenging oxygen free radicals through antioxidation and regulating aging genes [ 82 ]. Aging plays a vital role in AS, and an increase in the number of senescent cells and senescence-associated secretory phenotype (SASP) accelerates the AS process [ 83 ]. Autophagy plays a cellular scavenging role in maintaining cellular tissue homeostasis through lysosomal degradation and recycling of damaged organelles and misfolded proteins [ 84 ].…”

Section: Discussionmentioning

confidence: 99%

Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis

Ma,

Han,

Wang

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis

Ma,

Han,

Wang

et al. 2024

Heliyon

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“…Senescent endothelium cells experience considerable morphological and biological alterations. Large and flattened senescent endothelial cells, increased permeability to lipoproteins and other plasma components, decreased NO secretion, increased secretion of intercellular adhesion molecules and vascular cell adhesion molecules, increased expression of nuclear transcription factors, and cells in a proinflammatory and pro-apoptotic state are all characteristics of senescent endothelial cells [29] . There are two different aging processes.…”

Section: Other: Agingmentioning

confidence: 99%

The role of endothelial cells in the formation and progression of atherosclerosis

Wei,

Shi,

Zhang

et al. 2023

IJMRGE

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The functions of endothelial cells include physical barriers, sensory organs and endocrine organs, and all three of its functional abnormalities will lead to endothelial cell dysfunction, which will lead to the formation of atherosclerotic lesion initiation and continue to play an important role in the atherosclerotic process. Based on domestic and international research on endothelial cells and atherosclerosis, various causes of endothelial cell dysfunction and their important roles in the process of atherosclerosis will be explored, analyzed and synthesized, and finally the relationship between endothelial cell damage and the formation of atherosclerosis will be comprehensively analyzed at the molecular and individual levels, in order to provide new ideas and methods for the prevention and treatment of atherosclerosis.

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“…Atherosclerosis (AS) acts as chronic inflammatory vascular disorders with increasing morbidity worldwide, which is a deposition of plaque accumulation and multifactorial inflammatory process in vascular walls [ 1 , 2 ]. AS is responsible for occurrence of various clinical manifestation, e.g., coronary heart diseases, peripheral arterial disease and myocardial infarction and stroke [ 3 , 4 ]. Low density lipoprotein (LDL) functions as a basic factor of AS.…”

Section: Introductionmentioning

confidence: 99%

m6A ‘writer’ KIAA1429 regulates the proliferation and migration of endothelial cells in atherosclerosis

2022

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Increasing evidences have illustrated the important role of N 6 -methyladenosine (m 6 A) in atherosclerosis (AS). However, the role of m 6 A modification in AS pathophysiological process is still unknown. Here, the present work tried to investigate the expression and function of m 6 A methyltransferase KIAA1429 in AS pathology and explored its undergoing m 6 A-dependent molecular mechanism. Results indicated that KIAA1429 remarkedly up-regulated in oxidative low-density lipoprotein (ox-LDL)-treated human umbilical vein endothelial cells (HUVECs). KIAA1429 over-expression inhibited the proliferation/migration in ox-LDL-treated HUVECs, while, KIAA1429 knockdown up-regulated the proliferation and migration. Mechanistically, via m 6 A modification sites binding, ROCK2 mRNA was post-transcriptionally upregulated by KIAA1429 in response to Actinomycin D. Collectively, our study demonstrated the regulation of KIAA1429 on ox-LDL-induced HUVECs via m 6 A/ROCK2 pathway. These findings provide new insights for m 6 A-mediated epigenetics in AS. Supplementary Information The online version contains supplementary material available at 10.1007/s12033-022-00614-w.

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Advances in relationship between cell senescence and atherosclerosis

Abstract: Cellular senescence is a biological process associated with the degeneration of cell structure and function, which contribute to age-related diseases. Atherosclerosis is a chronic inflammatory disease that can cause a variety of cardiovascular disorders. In this

Cited by 4 publications

References 109 publications

Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis

Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis

The role of endothelial cells in the formation and progression of atherosclerosis

m6A ‘writer’ KIAA1429 regulates the proliferation and migration of endothelial cells in atherosclerosis

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