Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

Abstract

Infectious bone defects are characterized by the partial loss or destruction of bone tissue resulting from bacterial contaminations subsequent to diseases or external injuries. Traditional bone transplantation and clinical methods...

Advancing Bioactive Material for Mandibular Bone Regeneration: Transformation of Fibrous Mat into 3D Matrix Cotton for Enhanced Shape Retention and Rapid Hemostasis

“…In the intricate field of oral and maxillofacial surgery, managing mandibular defects poses a significant challenge, requiring both precision and innovation. These defects can stem from various causes, including trauma, congenital anomalies, tumor resections, and infectious processes. , Effective treatment demands a thorough understanding of the complex relationship between formation and function in the mandibular region. While vascularized autografts such as fibular flaps and iliac bone grafts are commonly used for mandibular reconstruction, issues persist with donor site morbidity and restoring the intricate geometry and occlusal function of the mandible. , Given the limitations of conventional therapies, the use of 3D scaffolds in hard tissue engineering shows promise for bone reconstruction.…”

“…These defects can stem from various causes, including trauma, congenital anomalies, tumor resections, and infectious processes. 1,2 Effective treatment demands a thorough understanding of the complex relationship between formation and function in the mandibular region. While vascularized autografts such as fibular flaps and iliac bone grafts are commonly used for mandibular reconstruction, issues persist with donor site morbidity and restoring the intricate geometry and occlusal function of the mandible.…”

“…In our study, we employed the electrospinning technique for fabricating fibrous mats and transformed them into 3D scaffolds using gas foaming technology. Gas foaming technology typically involves three major steps: (1) interacting the fibrous mat with a blowing agent solution, (2) nucleation of blowing agent gas bubbles, and (3) pore growth and volume expansion. The gas foaming technology has been widely utilized to fabricate spongy scaffolds with high porosities for tissue engineering and regeneration applications, its application in inflating electrospun nanofiber mats has been relatively limited.…”