Advances in Research on Anticancer Properties of Salidroside

Sun, An-Qi; Ju, Xin

doi:10.1007/s11655-020-3190-8

Cited by 27 publications

(14 citation statements)

References 49 publications

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“…SAL is an active component isolated from Rhodiola rosea, which has been validated to possess a broad spectrum of biological and pharmacological activities, containing anticancer, oxidant, and inflammatory 37 . In fact, SAL has been implicated in the modulation of antiproliferative activities in different forms of tumors, 38 including lung cancer 11,39 . Additionally, earlier reports indicated T cells, in particular CD8 + T cells, play an essential role in tumor elimination via identifying tumor‐specific antigens 40,41 .…”

Section: Discussionmentioning

confidence: 99%

Salidroside suppresses the multiple oncogenic activates and immune escape of lung adenocarcinoma through the circ_0009624‐mediated PD‐L1 pathway

Jin

Chen

et al. 2023

Thoracic Cancer

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BackgroundLung adenocarcinoma (LUAD) is a fatal malignancy all over the world. Salidroside (SAL) is an active component extracted from Rhodiola rosea that has been reported to exert antitumor activity against several human cancers, containing lung adenocarcinoma (LUAD). The purpose of this study was to explore the effect and underlying mechanism of SAL in LUAD.MethodsCell viability, proliferation, migration, and invasion were measured using cell counting kit‐8 (CCK‐8), 5‐ethynyl‐2′‐deoxyuridine (EdU), and transwell assays. Effects of LUAD cells on the cytotoxicity, percentage, and death of CD8+ cells were detected using lactate dehydrogenase (LDH) and flow cytometry assays. Programmed cell death ligand 1 (PD‐L1) protein level was examined using western blot. Circ_0009624, enolase 1 (ENO1), and PD‐L1 levels were determined using real‐time quantitative polymerase chain reaction (RT‐qPCR). The biological role of SAL on LUAD tumor growth was assessed using the xenograft tumor model in vivo.ResultsSAL restrained LUAD cell proliferation, migration, invasion, and immune escape in vitro via modulating PD‐L1. Circ_0009624 expression was increased in LUAD. Applying SAL repressed circ_0009624 and PD‐L1 expression in LUAD cells. SAL treatment hindered suppressed various oncogenic activates and immune escape of LUAD cells by regulating the circ_0009624/PD‐L1 pathway. SAL blocked LUAD xenograft growth in vivo.ConclusionApplying SAL might constrain malignant phenotypes and immune escape of LUAD cells partially through the circ_0009624‐mediated PD‐L1 pathway, providing a novel insight for LUAD treatment.

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Section: Discussionmentioning

confidence: 99%

Salidroside suppresses the multiple oncogenic activates and immune escape of lung adenocarcinoma through the circ_0009624‐mediated PD‐L1 pathway

Jin

Chen

et al. 2023

Thoracic Cancer

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“…Salidroside, also known as rhodioloside, rhodosin, tyrosol 8-O-glucoside or p-hydroxy phenethyl glucopyranoside, is a bioactive phenolic compound tyrosine derived from Rhodiola genus plants [144]. One of the principal biological activities related to Rhodiola rosea L. and salidroside is their activity in the pathogenic conditions of the central nervous system [145], osteoarthritis rat models inhibiting synovial inflammation [146] and alleviating cartilage degeneration [147], diabetic nephropathy in rats [148] and anticancer in vitro [149].…”

Section: Salidrosidementioning

confidence: 99%

Antiviral Role of Phenolic Compounds against Dengue Virus: A Review

et al. 2020

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Phenolic compounds have been related to multiple biological activities, and the antiviral effect of these compounds has been demonstrated in several viral models of public health concern. In this review, we show the antiviral role of phenolic compounds against dengue virus (DENV), the most widespread arbovirus globally that, after its re-emergence, has caused multiple epidemic outbreaks, especially in the last two years. Twenty phenolic compounds with anti-DENV activity are discussed, including the multiple mechanisms of action, such as those directed against viral particles or viral proteins, host proteins or pathways related to the productive replication viral cycle and the spread of the infection.

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“…18,19 It is anticipated that SAL will emerge as a novel medicine for adjuvant cancer treatment due to its therapeutic properties in malignant tumors, including lung cancer, colorectal cancer, and kidney cancer. 20 However, the protective effect and mechanism of salidroside (SAL) on LPS-induced kidney injury is unclear. Therefore, this research aims to investigate and provide precise information about the therapeutic effects of SAL regarding LPS-induced kidney injury and to explore the specific molecular mechanism.…”

Section: Introductionmentioning

confidence: 99%

Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway

Pan

Zhu

et al. 2023

Hum Exp Toxicol

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Background Salidroside (SAL) is an anti-inflammatory, antioxidant, anticancer, neuroprotective, and renal protective active ingredient extracted from the Chinese herb. Rhodiola Rosea. However, the role of SAL in kidney injury has not yet been elucidated. The study investigates SAL’s protective effect and mechanism in lipopolysaccharide (LPS)-induced kidney injury. Methods Male C57BL/6 wild-type mice (6–8 weeks old) were intraperitoneally injected with 10 mg/kg LPS for 24 h and SAL (50 mg/kg) 2 h before the LPS injection. Biochemical and TUNNEL staining assay analyses were carried out to assess kidney injury. The Elisa assay analyzed the mRNA expression of NGAL and KIM-1. RT-qPCR and Western blotting measured the mRNA and protein expression of HO-1, NQO1, Beclin1, P62, SIRT1, Nrf2, and PNCA, respectively. Results Our study found that mice co-treated with SAL had significantly reduced blood urea nitrogen (BUN), serum creatinine (Scr), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1) levels in serum of LPS-induced mice. SAL cotreatment potentially decreased the apoptosis rate of kidney tissue and podocytes induced by LPS. SAL significantly reduced the content of malondialdehyde (MDA) and increased superoxide dismutase (SOD) in LPS-treated mice. Autophagy-related proteins Beclin-1 increased but decreased P62 protein expression by cotreatment of SAL in LPS-injected mice. SAL enhanced the Sirtuin 1 (SIRT1) and nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression in LPS-induced kidney tissues. Conclusion Our results speculate that SAL protects against LPS-induced kidney injury through activation of the SIRT1/Nrf2 pathway.

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Advances in Research on Anticancer Properties of Salidroside

Cited by 27 publications

References 49 publications

Salidroside suppresses the multiple oncogenic activates and immune escape of lung adenocarcinoma through the circ_0009624‐mediated PD‐L1 pathway

Salidroside suppresses the multiple oncogenic activates and immune escape of lung adenocarcinoma through the circ_0009624‐mediated PD‐L1 pathway

Antiviral Role of Phenolic Compounds against Dengue Virus: A Review

Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway

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