Advances in Research on the Toxicological Effects of Selenium

Lv, Qizhuang; Liang, Xiaomei; Nong, Ke-yi; Gong, Zi-feng; Qin, Ting; Qin, Xinyun; Wang, Daobo; Zhu, Yong‐Guan

doi:10.1007/s00128-020-03094-3

Cited by 58 publications

(40 citation statements)

References 148 publications

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“…The decreased nematode abundance may be achieved through two mechanisms. On the one hand, excessive Se disturbs protein expression and the antioxidant defense system directly in nematodes (Lv et al, 2021 ). On the other hand, it is likely that the changes in biotic (microorganisms and plant roots) and abiotic (soil properties) factors induced by Se decreased nematode abundance indirectly (Liu et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…Considering the multiple effects of Se (Lv et al, 2021 ), we hypothesized that soil nematodes will not be disturbed under biofortification with a small amount of Se, while excessive Se may harm soil nematodes and affect plant growth. To test this hypothesis, a rice pot experiment with selenite supplementation at different concentrations was carried out.…”

Section: Introductionmentioning

confidence: 99%

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Selenium Effect Threshold for Soil Nematodes Under Rice Biofortification

et al. 2022

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Crop biofortification with inorganic selenium (Se) fertilizer is a feasible strategy to improve the health of residents in Se-deficient areas. For eco-friendly crop Se biofortification, a comprehensive understanding of the effects of Se on crop and soil nematodes is vital. In this study, a rice pot experiment was carried out to test how selenite supply (untreated control (0), 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 100, or 200 mg Se kg−1) in soil affected rice growth, rice Se accumulation, and soil nematode abundance and composition. The results showed that selenite supply (5–200 mg kg−1) generally increased the number of rice tillers, rice yield, and Se concentrations in rice grains. In soil under 10 mg kg−1 Se treatment, the genus composition of nematodes changed significantly compared with that in the control soil. With increased Se level (> 10 mg kg−1), soil nematode abundance decreased significantly. Correlation analysis also demonstrated the positive relationships between soil Se concentrations (total Se and bioavailable Se) with rice plant parameters (number of rice tillers, rice yield, and grain Se concentration) and negative relationships between soil Se concentrations (total Se and bioavailable Se) with soil nematode indexes (nematode abundance and relative abundance of Tobrilus). This study provides insight into balancing Se biofortification of rice and soil nematode community protection and suggests the effective concentrations for total Se (1.45 mg kg−1) and bioavailable Se (0.21 mg kg−1) to soil nematode abundances at 20% level (EC20) as soil Se thresholds. At Se concentrations below these thresholds, rice plant growth and Se accumulation in the grain will still be promoted, but the disturbance of the soil nematodes would be negligible.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selenium Effect Threshold for Soil Nematodes Under Rice Biofortification

et al. 2022

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“…Moreover, Se can regulate macrophage phenotypes and improve the anti-inflammatory function of macrophages to promote tissue repair and cell proliferation [ 17 ]. However, its relatively narrow range between an effective concentration and toxicity limits the application of Se-containing drugs [ 18 ]. Hence, we previously developed porous SiO 2 -coated ultrasmall Se particles (Se@SiO 2 nanospheres) for drug delivery, which slowly release effective Se at effective concentrations, thereby reducing toxicity and improving biocompatibility [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis

et al. 2021

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Background Inflammatory osteolysis, a major complication of total joint replacement surgery, can cause prosthesis failure and necessitate revision surgery. Macrophages are key effector immune cells in inflammatory responses, but excessive M1-polarization of dysfunctional macrophages leads to the secretion of proinflammatory cytokines and severe loss of bone tissue. Here, we report the development of macrophage-biomimetic porous SiO2-coated ultrasmall Se particles (porous Se@SiO2 nanospheres) to manage inflammatory osteolysis. Results Macrophage membrane-coated porous Se@SiO2 nanospheres(M-Se@SiO2) attenuated lipopolysaccharide (LPS)-induced inflammatory osteolysis via a dual-immunomodulatory effect. As macrophage membrane decoys, these nanoparticles reduced endotoxin levels and neutralized proinflammatory cytokines. Moreover, the release of Se could induce macrophage polarization toward the anti-inflammatory M2-phenotype. These effects were mediated via the inhibition of p65, p38, and extracellular signal-regulated kinase (ERK) signaling. Additionally, the immune environment created by M-Se@SiO2 reduced the inhibition of osteogenic differentiation caused by proinflammation cytokines, as confirmed through in vitro and in vivo experiments. Conclusion Our findings suggest that M-Se@SiO2 have an immunomodulatory role in LPS-induced inflammation and bone remodeling, which demonstrates that M-Se@SiO2 are a promising engineered nanoplatform for the treatment of osteolysis occurring after arthroplasty. Graphical Abstract

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“…Selenium nanoparticles (SeNPs) are nano-sized (generally <60 nm in diameter) elemental selenium particles with excellent nano-properties [109]. For the NPs' synthesis, there are two main strategies used: bottom-up (including chemical vapor deposition, hydrothermal and solvothermal methods, chemical reduction, and green synthesis) and top-down (including mechanical milling, laser ablation, etching, sputtering, and electro-explosion).…”

Section: Selenium Nanoparticles In Animal Nutritionmentioning

confidence: 99%

Biogenic Selenium Nanoparticles in Animal Nutrition: A Review

et al. 2021

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Selenium still represents a matter of debate in the scientific community. Bionanotechnology has introduced a whole new perspective on selenium use in animal nutrition. In recent years, attention has been focused on selenium nanoparticles prepared by chemical synthesis. Societal pressure directs research in a “greenway” that is more eco-friendly. Biogenic selenium nanoparticles thus represent a new space for research in the use of this new form of selenium in animal nutrition. Recent research shows that biogenic selenium nanoparticles have low toxicity, improve antioxidant status, and increase the body’s immune response. However, their benefits may be much greater, as numerous in vitro studies have shown. In addition, biogenic selenium nanoparticles possess antimicrobial, antifungal, and anticancer activities. Further research should answer questions on the use of biogenic selenium nanoparticles as a feed supplement in individual categories of livestock, and their safety in terms of long-term supplementation.

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Advances in Research on the Toxicological Effects of Selenium

Cited by 58 publications

References 148 publications

Selenium Effect Threshold for Soil Nematodes Under Rice Biofortification

Selenium Effect Threshold for Soil Nematodes Under Rice Biofortification

Macrophage-biomimetic porous Se@SiO2 nanocomposites for dual modal immunotherapy against inflammatory osteolysis

Biogenic Selenium Nanoparticles in Animal Nutrition: A Review

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