Advances in single-cell multi-omics methods and their applications in developmental biology

Cheng, Xin; Yan, Rui; Guo, Fan

doi:10.1360/ssv-2020-0244

Cited by 1 publication

(1 citation statement)

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“…These findings can provide an in-depth understanding of biological processes and therefore foster the development of improved therapeutic agents (Figure ). Capitalizing on this, multiomics analyses have become essential tools for molecular compounds. − Hundreds of molecular targeted drugs have been developed and approved by the FDA over the past decade, highlighting the enormous impact of multiomics on life sciences.…”

Section: What Is Nanomedomics?mentioning

confidence: 99%

Nanomedomics

Liang,

Cao,

Tang

et al. 2024

ACS Nano

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Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles have been widely developed for nanomedicine via chemical conjugation or physical encapsulation of bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, and tumor-targeting properties. Capitalizing on this, several nanoformulations have already been clinically approved and many others are currently being studied in clinical trials. Despite their undoubtful success, the molecular mechanism of action of the vast majority of nanomedicines remains poorly understood. To tackle this limitation, herein, this review critically discusses the strategy of applying multiomics analysis to study the mechanism of action of nanomedicines, named nanomedomics, including advantages, applications, and future directions. A comprehensive understanding of the molecular mechanism could provide valuable insight and therefore foster the development and clinical translation of nanomedicines.

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Section: What Is Nanomedomics?mentioning

confidence: 99%