Advances in Single-component inorganic nanostructures for photoacoustic imaging guided photothermal therapy

Zhu, Houjuan; Li, Bofan; Chan, Chui Yu; Ling, Beverly Low Qian; Tor, Jiaqian; Oh, Xin Yi; Jiang, Wenbin; Ye, Enyi; Liu, Yupeng; Loh, Xian Jun

doi:10.1016/j.addr.2022.114644

Cited by 50 publications

(27 citation statements)

References 292 publications

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“…However, despite their biocompatibility and light-sensitive ability, this tool’s primary challenge is the drug field’s poor pharmacokinetics. , Additionally, low permeation of light-sensitive drugs via nanotheranostics into the solid tumor is associated with phototoxicity, which stays in the systemic circulation for several weeks, which limits its use as a nanotheranostic. , Photosensitive nanotheranostics also pose the challenge of photobleaching, making room for more improvements. Critical challenges associated with metallic nanotheranostics − include retarded degradation and high cytotoxicity. In contrast, with nonmetallic nanotheranostics, the premature release of payload, with biological nanotheranostics, is a high-affinity binding with target proteins and quantum-dot-based nanotheranostics in rapid first-pass metabolism and clearance …”

Section: Interplay Of Known and Unknown Factorsmentioning

confidence: 99%

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Chavda,

Balar,

Nalla

et al. 2023

ACS Omega

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Cancer diagnoses have been increasing worldwide, and solid tumors are among the leading contributors to patient mortality, creating an enormous burden on the global healthcare system. Cancer is responsible for around 10.3 million deaths worldwide. Solid tumors are one of the most prevalent cancers observed in recent times. On the other hand, early diagnosis is a significant challenge that could save a person's life. Treatment with existing methods has pitfalls that limit the successful elimination of the disorder. Though nanoparticle-based imaging and therapeutics have shown a significant impact in healthcare, current methodologies for solid tumor treatment are insufficient. There are multiple complications associated with the diagnosis and management of solid tumors as well. Recently, surface-conjugated nanoparticles such as lipid nanoparticles, metallic nanoparticles, and quantum dots have shown positive results in solid tumor diagnostics and therapeutics in preclinical models. Other nanotheranostic material platforms such as plasmonic theranostics, magnetotheranostics, hybrid nanotheranostics, and graphene theranostics have also been explored. These nanoparticle theranostics ensure the appropriate targeting of tumors along with selective delivery of cargos (both imaging and therapeutic probes) without affecting the surrounding healthy tissues. Though they have multiple applications, nanoparticles still possess numerous limitations that need to be addressed in order to be fully utilized in the clinic. In this review, we outline the importance of materials and design strategies used to engineer nanoparticles in the treatment and diagnosis of solid tumors and how effectively each method overcomes the drawbacks of the current techniques. We also highlight the gaps in each material platform and how design considerations can address their limitations in future research directions.

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Section: Interplay Of Known and Unknown Factorsmentioning

confidence: 99%

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Chavda,

Balar,

Nalla

et al. 2023

ACS Omega

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“…Most of the currently developed multifunctional NPs contain two or more inorganic nanomaterials, or carry multiple cargoes 178,179 . The clinical translation of multifunctional NPs is limited due to the complexity of their preparation process or unsatisfactory performance in a single function 180 . A recent study successfully utilized a straightforward solvent evaporation‐driven technique to achieve the self‐assembly formation of a multifunctional nano‐agent with multiple components 181 .…”

Section: Inp‐integrated Mscs For Simultaneous Treatment and Trackingmentioning

confidence: 99%

Inorganic nanoparticle‐integrated mesenchymal stem cells: A potential biological agent for multifaceted applications

Zheng,

Jiang,

et al. 2023

MedComm

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Mesenchymal stem cell (MSC)‐based therapies are flourishing. MSCs could be used as potential therapeutic agents for regenerative medicine due to their own repair function. Meanwhile, the natural predisposition toward inflammation or injury sites makes them promising carriers for targeted drug delivery. Inorganic nanoparticles (INPs) are greatly favored for their unique properties and potential applications in biomedical fields. Current research has integrated INPs with MSCs to enhance their regenerative or antitumor functions. This model also allows the in vivo fate tracking of MSCs in multiple imaging modalities, as many INPs are also excellent contrast agents. Thus, INP‐integrated MSCs would be a multifunctional biologic agent with great potential. In this review, the current roles performed by the integration of INPs with MSCs, including (i) enhancing their repair and regeneration capacity via the improvement of migration, survival, paracrine, or differentiation properties, (ii) empowering tumor‐killing ability through agent loaded or hyperthermia, and (iii) conferring traceability are summarized. An introduction of INP‐integrated MSCs for simultaneous treatment and tracking is also included. The promising applications of INP‐integrated MSCs in future treatments are emphasized and the challenges to their clinical translation are discussed.

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“…16,17 Due to the PTA with specic photophysical properties, it can be used for tumor imaging, such as thermal imaging, uorescence imaging (FL), and photoacoustic imaging (PAI), which has great potential for application in tumor visualization and treatment. 18,19 The effectiveness of PTT largely depends on the photothermal conversion efficiency of PTAs. 16,20,21 Therefore, it is critical to prepare PTAs with high photothermal conversion efficiency and strong NIR light absorption to achieve optimal PTT outcomes.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials for photothermal cancer therapy

Duan

Zhao

et al. 2023

RSC Adv.

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Advances in Single-component inorganic nanostructures for photoacoustic imaging guided photothermal therapy

Cited by 50 publications

References 292 publications

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Inorganic nanoparticle‐integrated mesenchymal stem cells: A potential biological agent for multifaceted applications

Nanomaterials for photothermal cancer therapy

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