Advances in stem cell treatment for sciatic nerve injury

Sayad-Fathi, Sara; Nasiri, Ebrahim; Zaminy, Arash

doi:10.1080/14712598.2019.1576630

Cited by 23 publications

(20 citation statements)

References 90 publications

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“…In regenerative medicine and tissue engineering, the use of Stem Cells and their secretome is fast expanding with the aim to develop innovative therapeutic strategies for the treatment of peripheral nerve injuries (Caplan, 2015; Caseiro et al, 2016; Busuttil et al, 2017; Sayad-Fathi et al, 2019). In particular, Mesenchymal Stem Cells (MSCs) present relevant key features: they can be easily expanded, they can differentiate into different cell types, they are immune-privileged and immune-modulatory, they show preferential homing to injured sites (Frausin et al, 2015; Sullivan et al, 2016; Jiang et al, 2017).…”

Section: Methodological Considerations – Approaches For the Treatmentmentioning

confidence: 99%

The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations

Ronchi

Morano

Fregnan

et al. 2019

Front. Cell. Neurosci.

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The successful introduction of innovative treatment strategies into clinical practise strongly depends on the availability of effective experimental models and their reliable pre-clinical assessment. Considering pre-clinical research for peripheral nerve repair and reconstruction, the far most used nerve regeneration model in the last decades is the sciatic nerve injury and repair model. More recently, the use of the median nerve injury and repair model has gained increasing attention due to some significant advantages it provides compared to sciatic nerve injury. Outstanding advantages are the availability of reliable behavioural tests for assessing posttraumatic voluntary motor recovery and a much lower impact on the animal wellbeing. In this article, the potential application of the median nerve injury and repair model in pre-clinical research is reviewed. In addition, we provide a synthetic overview of a variety of methods that can be applied in this model for nerve regeneration assessment. This article is aimed at helping researchers in adequately adopting this in vivo model for pre-clinical evaluation of peripheral nerve reconstruction as well as for interpreting the results in a translational perspective.

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Section: Methodological Considerations – Approaches For the Treatmentmentioning

confidence: 99%

The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations

Ronchi

Morano

Fregnan

et al. 2019

Front. Cell. Neurosci.

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“…Dental pulp stem cells (DPSCs) are also a source of NCLSCs that have multilineage differentiation potential, immunomodulatory properties, and high regenerative capability 126,127 . As a result, DPSCS can be utilized to treat a broad spectrum of disorders, 126,127 including PNI, 128,129 retinal injury, diabetes, cerebral ischemia, myocardial infarction, muscular dystrophy, and neurological diseases 128,130,131 . Indeed, in several case studies and preliminary clinical trials, the transplantation of DPSCs has proven to be a safe and effective therapeutic strategy, 127 indicating that DPSCs are a promising cell source for tissue regeneration and the treatment of various diseases.…”

Section: Introductionmentioning

confidence: 99%

Neural crest-like stem cells for tissue regeneration

Soto

Ding

Wang

et al. 2021

Stem Cells Translational Medicine

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Neural crest stem cells (NCSCs) are a transient population of cells that arise during early vertebrate development and harbor stem cell properties, such as self‐renewal and multipotency. These cells form at the interface of non‐neuronal ectoderm and neural tube and undergo extensive migration whereupon they contribute to a diverse array of cell and tissue derivatives, ranging from craniofacial tissues to cells of the peripheral nervous system. Neural crest‐like stem cells (NCLSCs) can be derived from pluripotent stem cells, placental tissues, adult tissues, and somatic cell reprogramming. NCLSCs have a differentiation capability similar to NCSCs, and possess great potential for regenerative medicine applications. In this review, we present recent developments on the various approaches to derive NCLSCs and the therapeutic application of these cells for tissue regeneration.

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“…Peripheral nerve injury (PNI) is a critical issue in the field of regenerative medicine ( Wang et al, 2018 ; Li et al, 2020 ). Accelerating axonal regeneration and improving functional recovery after PNI is a clinical dilemma and a basic medical challenge ( Li et al, 2019 ; Sayad-Fathi et al, 2019 ). In clinical practice, end-to-end suturing of proximal and distal stumps is the ideal method to repair short nerve defect ( Guo et al, 2019 ; Wu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Brain Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor-Transfected Bone Mesenchymal Stem Cells for the Repair of Periphery Nerve Injury

Zhang¹,

Wu²,

Chen³

et al. 2020

Front. Bioeng. Biotechnol.

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Peripheral nerve injury is a common clinical neurological disease. In our previous study, highly oriented poly ( L -lactic acid) (PLLA)/soy protein isolate (SPI) nanofiber nerve conduits were constructed and exhibited a certain repair capacity for peripheral nerve injury. In order to further improve their nerve repairing efficiency, the bone mesenchymal stem cells (BMSCs) overexpressing brain derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) were introduced into the conduits as seed cells and then were used to repair the 10-mm sciatic nerve defects in rats. The nerve repair efficiency of the functional nerve conduits was evaluated by gait experiment, electrophysiological test, and a series of assays such as hemotoxylin-eosin (HE) staining, immunofluorescence staining, toluidine blue (TB) staining, transmission electron microscopy (TEM) observation of regenerated nerve and Masson’s trichrome staining of gastrocnemius muscle. The results showed that the conduits containing BMSCs overexpressing BDNF and GDNF double-factors group had better nerve repairing efficiency than blank BMSCs and single BDNF or GDNF factor groups, and superior to autografts group in some aspects. These data demonstrated that BDNF and GDNF produced by BMSCs could synergistically promote peripheral nerve repair. This study shed a new light on the conduits and stem cells-based peripheral nerve repair.

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Advances in stem cell treatment for sciatic nerve injury

Cited by 23 publications

References 90 publications

The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations

The Median Nerve Injury Model in Pre-clinical Research – A Critical Review on Benefits and Limitations

Neural crest-like stem cells for tissue regeneration

Brain Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor-Transfected Bone Mesenchymal Stem Cells for the Repair of Periphery Nerve Injury

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