Advances in structure-switching aptasensing towards real time detection of cytokines

Cao, Chaomin; Zhang, Fuyuan; Goldys, Ewa M.; Gao, Fang; Liu, Guozhen

doi:10.1016/j.trac.2018.03.002

Cited by 51 publications

(46 citation statements)

References 201 publications

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“…However, the method suffers from some limitations—for example, it requires careful control to conjugate antibodies on the nanospheres, and the stability of probe is remained to be optimized. To overcome the limitation of antibody, one can utilize aptamers with high affinity and stability as a good alternative [ 67 ].…”

Section: Sample Pretreatment In Different Detection Platforms For mentioning

confidence: 99%

Food Safety in Post-COVID-19 Pandemic: Challenges and Countermeasures

Zhang

Zhu

et al. 2021

Biosensors

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Understanding food safety hazard risks is essential to avoid potential negative heath impacts in the food supply chain in a post-COVID-19 pandemic era. Development of strategies for virus direction in foods plays an important role in food safety and verification. Early warning, tracing, and detection should be implemented as an integrated system in order to mitigate thecoronavirus disease 2019 (COVID-19) outbreak, in which the detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is critical as it not only concerns screening of populations but also monitoring of possible contaminated sources such as the food supply chain. In this review, we point out the consequences in different aspects of our daily life in the post-COVID-19 pandemic from the perspective of the food supply chain and the food industry. We summarize the possible transmission routes of COVID-19 in the food supply chain before exploring the development of corresponding detection tools of SARS-CoV-2. Accordingly, we compare different detection methods for the virus in foods, including different pretreatments of food matrices in the virus detection. Finally, the future perspectives are proposed.

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Section: Sample Pretreatment In Different Detection Platforms For mentioning

confidence: 99%

Food Safety in Post-COVID-19 Pandemic: Challenges and Countermeasures

Zhang

Zhu

et al. 2021

Biosensors

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“…For example, transport needs to be refrigerated and antibodies/nanobodies need to be kept cool to ensure they remain functional, whereas aptamers are stable at higher temperatures [53,100]. Additionally, while aptamers have been used to replace antibodies in typical laboratory tests, they have also come into their own in a number of in vitro diagnostic assays that would be easily adapted to in field or POCT [101][102][103][104].…”

Section: In Vitro Applications: Which Is Best?mentioning

confidence: 99%

Antibodies, Nanobodies, or Aptamers—Which Is Best for Deciphering the Proteomes of Non-Model Species?

Dhar

Samarasinghe

Shigdar

2020

IJMS

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This planet is home to countless species, some more well-known than the others. While we have developed many techniques to be able to interrogate some of the “omics”, proteomics is becoming recognized as a very important part of the puzzle, given how important the protein is as a functional part of the cell. Within human health, the proteome is fairly well-established, with numerous reagents being available to decipher cellular pathways. Recent research advancements have assisted in characterizing the proteomes of some model (non-human) species, however, in many other species, we are only just touching the surface. This review considers three main reagent classes—antibodies, aptamers, and nanobodies—as a means of continuing to investigate the proteomes of non-model species without the complications of understanding the full protein signature of a species. Considerations of ease of production, potential applications, and the necessity for producing a new reagent depending on homology are presented.

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“…For example, Xia and coworkers developed an electrochemical DNA sensor (E‐DNA) based on the target‐driven DNA triplex formation which could generate an electrochemical output, thus supporting the continuous, real‐time measurement of melamine in flowing milk, [ 24 ] and HIV‐diagnostic antibodies in human serum. [ 25 ] Moreover, structure‐switchable aptamers have demonstrated promising performances in the real‐time detection of cytokines in vivo, [ 26 ] which is typically low abundances in physiological conditions and thus the aptasensing shows great value in biology and medicine. [ 27 ] Through decoration of graphene/methylene‐blue/Au nanocomposites with ferrocene‐labeled aptamer, Liu and coworkers successfully realized the real‐time detection of vascular endothelial growth factor in serum in a wide linear range (2–500 pg mL −1 ) with a much lower detection limit (0.1 pg mL −1 ).…”

Section: Biosensing Applications Based On Low‐order Dna‐crnsmentioning

confidence: 99%

“…As one typical example of reversible DNA‐CRNs, DNA nanoswitch can undergo a reversible structural change upon addition or removal of external stimuli such as analytes, [ 26 ] enzymes, [ 31 ] metal ions, [ 32 ] or pH values. [ 33 ] As an example, Figure 3b shows a pH‐dependant DNA nanoswitch for monitoring dynamical changes of intracellular pH.…”

Section: Biosensing Applications Based On Low‐order Dna‐crnsmentioning

confidence: 99%

DNA‐Based Chemical Reaction Networks for Biosensing Applications

Jiang

Yuan

et al. 2020

Advanced Intelligent Systems

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The nature of biosensing is a biochemical reaction. DNA‐based chemical reaction networks (DNA‐CRNs) as a powerful programming language for describing behaviors of chemical reactions have shown great potential in designs and applications of biosensors. Due to their programmability, modularity, and versatility of the DNA strand, the performance of different detection strategies can be improved mainly by the rational design of DNA‐CRNs. Herein, an overview of the fundamental theory and biosensing processes of DNA‐CRNs is provided. Various detection strategies of DNA‐CRNs are introduced, either in a simple low‐order reaction model or in a complicated high‐order reaction type, in combination with some typical cases for the different detection purposes. In addition, an overview of the recent development of DNA‐CRNs for monitoring the cell microenvironment is presented, which is of significance to uncover some specific cell behaviors and functions. Finally, the roles of DNA‐CRNs in the rational design of high‐performance biosensors are summarized by pointing out the remaining challenges that impede the precise biosensing using DNA‐CRNs in complicated biological environments.

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Advances in structure-switching aptasensing towards real time detection of cytokines

Cited by 51 publications

References 201 publications

Food Safety in Post-COVID-19 Pandemic: Challenges and Countermeasures

Food Safety in Post-COVID-19 Pandemic: Challenges and Countermeasures

Antibodies, Nanobodies, or Aptamers—Which Is Best for Deciphering the Proteomes of Non-Model Species?

DNA‐Based Chemical Reaction Networks for Biosensing Applications

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