Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

Abstract

Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients. In the treatment of oral ulcers, nanofiber films can control the drug-release rate and enable long-term local administration. Compared to other drug-delivery methods, nanofiber films avoid the disadvantages of frequent administration and certain side effects. Electrospinning is a simple and effective method for preparing nanofiber films. Currently, electrospinning technology has made significant breakthroughs in energy-saving and large-scale production. This paper summarizes the polymers that enable oral mucosal adhesion and the active pharmaceutical ingredients used for oral ulcers. Moreover, the therapeutic effects of currently available electrospun nanofiber films on oral ulcers in animal experiments and clinical trials are investigated. In addition, solvent casting and cross-linking methods can be used in conjunction with electrospinning techniques. Based on the literature, more administration systems with different polymers and loading components can be inspired. These administration systems are expected to have synergistic effects and achieve better therapeutic effects. This not only provides new possibilities for drug-loaded nanofibers but also brings new hope for the treatment of oral ulcers.

Processes of Electrospun Polyvinylidene Fluoride-Based Nanofibers, Their Piezoelectric Properties, and Several Fantastic Applications

“…The morphology and properties of NFs are mainly determined by the following three aspects: process parameters, the nature of the polymer solution, and environmental parameters [ 79 , 80 , 81 , 82 , 83 ]. The influence of three parameters on the morphology and piezoelectric properties of PVDF is introduced in the following section.…”

Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing

“…Nanofibers created utilizing electrospinning technology have shown outstanding wound healing properties. Their architecture closely resembles the human ECM structure and may be used as a dressing to promote cell adhesion and proliferation, eventually prompting new skin regeneration [ 105 , 106 ]. Simultaneously, the high permeability and absorption rate may absorb the exudate created on the trauma site and keep the healing environment moist [ 107 , 108 ].…”

Recent Progress of Electrospun Herbal Medicine Nanofibers

“…These properties can support cell synthesis of specific proteins and other biochemical and biological processes required for healthy tissue growth [28,83]. Therefore, electrospun fibers have become excellent candidates for various applications, such as catalysis [84], filtration [85], water treatment [86][87][88][89], biosensors [90][91][92], food packaging [93,94], cosmetics [95] and biomedicine [96][97][98][99][100][101].…”