“…When the target molecules are adsorbed into a roughened surface of nano-noble metals, a severe increase in the incident electromagnetic field and chemical charge transfers occurs, resulting in more intensive Raman signals (10 6 –10 14 times over that of a flat surface) [17,30]. This allows the detection of organic coupled nanoparticles at picomolar concentrations even in deep tissues and makes it an ideal in vivo detector (Figure 2) [4,31]. 10.1080/20022727.2017.1373551-F0002Figure 2.Schematic of the Raman spectra-imaging system.…”
Section: Principles Of Raman Spectroscopymentioning
confidence: 99%
“…proteins, antibodies, aptamers, and small molecules), aiming for specific receptors, proteins and cell types [28,41,55,56]. Regarding the shape of AuNPs, some advantages were demonstrated when using star structures, but much work has also been done with spheres [4]. Silver nanoparticles (AgNPs) can also be used in correlation with RS and SERS.…”
Section: Nanoparticles and Raman Techniquesmentioning
confidence: 99%
“…Accordingly, among the numerous techniques based on Raman, SERS seems to be more capable of achieving this purpose [4,69]. …”
Section: Cancer Detection Using Ramanmentioning
confidence: 99%
“…Cancer detection with a handheld instrument is now possible [4]. Raman spectroscopy (RS) is a powerful analytical technique that can be used in the detection of biological specimens, even a single cell.…”
Section: Introductionmentioning
confidence: 99%
“…Though RS is not a novel technology, its application for cancer detection is new. Recent advances in RS include in vivo trials [4–6]. RS can measure the chemical composition of complex biological samples [7].…”
In vitro detection technique Raman spectroscopy (Rs), in one number times another Rs based expert ways of art and so on, are useful instruments for cancer discovery. top gave greater value to Raman spectroscopy sers is a relatively new careful way for in vitro and in vivo discovery that takes away bad points of simple Raman spectroscopy (Rs). Raman spectroscopy (RS) and in particular, multiple RS-based techniques are useful for cancer detection. Surface enhanced Raman spectroscopy (SERS) is a relatively new method for both in vitro and in vivo detection, which eliminates the drawbacks of simple RS. Using nanoparticles has elevated the sensitivity and specificity of SERS. SERS has the potential to increase sensitivity, specificity and spatial resolution in cancer detection, especially in cooperation with other diagnostic imaging tools such as magnetic resonance imaging (MRI) and PET-scan polyethylene terephthalate. Developing a hand held instrument for detecting cancer or other illnesses may also be feasible by using SERS. Frequently, novel nanoparticles are used in SERS. With a focus on nanoparticle utilization, we review the benefits of RS in cancer detection and related biomarkers. With a focus on nanoparticles utilizations, the benefits of RS in cancer detection and related biomarkers were reviewed. In addition, Raman applications to detect some of prevalent were discussed. Also more investigated cancers such as breast and colorectal cancer, multiple nanostructures and their possible special biomarkers, especially as SERS nano-tag have been reviewed. The main purpose of this article is introducing of most popular nanotechnological approaches in cancer detection by using Raman techniques. Moreover, have been caught up on detection and reviewed some of the most prevalent and also more investigated cancers such as breast, colorectal cancer, multiple intriguing nanostructures, especially as SERS nano-tag, special cancer biomarkers and related approaches. The main purpose of this article is to introduce the most popular nanotechnological approaches in cancer detection by using Raman techniques.
“…When the target molecules are adsorbed into a roughened surface of nano-noble metals, a severe increase in the incident electromagnetic field and chemical charge transfers occurs, resulting in more intensive Raman signals (10 6 –10 14 times over that of a flat surface) [17,30]. This allows the detection of organic coupled nanoparticles at picomolar concentrations even in deep tissues and makes it an ideal in vivo detector (Figure 2) [4,31]. 10.1080/20022727.2017.1373551-F0002Figure 2.Schematic of the Raman spectra-imaging system.…”
Section: Principles Of Raman Spectroscopymentioning
confidence: 99%
“…proteins, antibodies, aptamers, and small molecules), aiming for specific receptors, proteins and cell types [28,41,55,56]. Regarding the shape of AuNPs, some advantages were demonstrated when using star structures, but much work has also been done with spheres [4]. Silver nanoparticles (AgNPs) can also be used in correlation with RS and SERS.…”
Section: Nanoparticles and Raman Techniquesmentioning
confidence: 99%
“…Accordingly, among the numerous techniques based on Raman, SERS seems to be more capable of achieving this purpose [4,69]. …”
Section: Cancer Detection Using Ramanmentioning
confidence: 99%
“…Cancer detection with a handheld instrument is now possible [4]. Raman spectroscopy (RS) is a powerful analytical technique that can be used in the detection of biological specimens, even a single cell.…”
Section: Introductionmentioning
confidence: 99%
“…Though RS is not a novel technology, its application for cancer detection is new. Recent advances in RS include in vivo trials [4–6]. RS can measure the chemical composition of complex biological samples [7].…”
In vitro detection technique Raman spectroscopy (Rs), in one number times another Rs based expert ways of art and so on, are useful instruments for cancer discovery. top gave greater value to Raman spectroscopy sers is a relatively new careful way for in vitro and in vivo discovery that takes away bad points of simple Raman spectroscopy (Rs). Raman spectroscopy (RS) and in particular, multiple RS-based techniques are useful for cancer detection. Surface enhanced Raman spectroscopy (SERS) is a relatively new method for both in vitro and in vivo detection, which eliminates the drawbacks of simple RS. Using nanoparticles has elevated the sensitivity and specificity of SERS. SERS has the potential to increase sensitivity, specificity and spatial resolution in cancer detection, especially in cooperation with other diagnostic imaging tools such as magnetic resonance imaging (MRI) and PET-scan polyethylene terephthalate. Developing a hand held instrument for detecting cancer or other illnesses may also be feasible by using SERS. Frequently, novel nanoparticles are used in SERS. With a focus on nanoparticle utilization, we review the benefits of RS in cancer detection and related biomarkers. With a focus on nanoparticles utilizations, the benefits of RS in cancer detection and related biomarkers were reviewed. In addition, Raman applications to detect some of prevalent were discussed. Also more investigated cancers such as breast and colorectal cancer, multiple nanostructures and their possible special biomarkers, especially as SERS nano-tag have been reviewed. The main purpose of this article is introducing of most popular nanotechnological approaches in cancer detection by using Raman techniques. Moreover, have been caught up on detection and reviewed some of the most prevalent and also more investigated cancers such as breast, colorectal cancer, multiple intriguing nanostructures, especially as SERS nano-tag, special cancer biomarkers and related approaches. The main purpose of this article is to introduce the most popular nanotechnological approaches in cancer detection by using Raman techniques.
Surface‐enhanced Raman spectroscopy is a powerful and sensitive analytical tool that has found application in chemical and biomolecule analysis and environmental monitoring. Since its discovery in the early 1970s, a variety of materials ranging from noble metals to nanostructured materials have been employed as surface enhanced Raman scattering (SERS) substrates. In recent years, 2D inorganic materials have found wide use in the development of SERS‐based chemical sensors owing to their unique thickness dependent physico‐chemical properties with enhanced chemical‐based charge‐transfer processes. Here, recent advances in the application of various 2D inorganic nanomaterials, including graphene, boron nitride, semiconducting metal oxides, and transition metal chalcogenides, in chemical detection via SERS are presented. The background of the SERS concept, including its basic theory and sensing mechanism, along with the salient features of different nanomaterials used as substrates in SERS, extending from monometallic nanoparticles to nanometal oxides, is comprehensively discussed. The importance of 2D inorganic nanomaterials in SERS enhancement, along with their application toward chemical detection, is explained in detail with suitable examples and illustrations. In conclusion, some guidelines are presented for the development of this promising field in the future.
Early clinical diagnosis, effective intraoperative guidance, and an accurate prognosis can lead to timely and effective medical treatment. The current conventional clinical methods have several limitations. Therefore, there is a need to develop faster and more reliable clinical detection, treatment, and monitoring methods to enhance their clinical applications. Raman spectroscopy is noninvasive and provides highly specific information about the molecular structure and biochemical composition of analytes in a rapid and accurate manner. It has a wide range of applications in biomedicine, materials, and clinical settings. This review primarily focuses on the application of Raman spectroscopy in clinical medicine. The advantages and limitations of Raman spectroscopy over traditional clinical methods are discussed. In addition, the advantages of combining Raman spectroscopy with machine learning, nanoparticles, and probes are demonstrated, thereby extending its applicability to different clinical phases. Examples of the clinical applications of Raman spectroscopy over the last 3 years are also integrated. Finally, various prospective approaches based on Raman spectroscopy in clinical studies are surveyed, and current challenges are discussed.
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