Advances in the control of (cat flea) on cats and dogs

Rust, Michael Κ.

doi:10.1016/j.pt.2005.03.010

Cited by 160 publications

(108 citation statements)

References 44 publications

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“…1), referred to as neonicotinoids, are used worldwide as agrochemicals (Matsuda et al, 2001Tomizawa and Casida, 2005). In addition, neonicotinoids are employed in animal health as flea repellants (Mencke and Jeschke, 2002;Rust, 2005). Most neonicotinoids are partial agonists of native (Nagata et al, 1996;Deglise et al, 2002;Ihara et al, 2006) and recombinant (Shimomura et al, 2002(Shimomura et al, , 2004Ihara et al, 2003Ihara et al, , 2004Matsuda et al, 1998Matsuda et al, , 2005 nAChRs, but some antagonize the acetylcholineinduced responses of native insect neurons (Salgado and Saar, 2004;Ihara et al, 2006) and others show superagonist actions (Ihara et al, 2004).…”

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confidence: 99%

Role in the Selectivity of Neonicotinoids of Insect-Specific Basic Residues in Loop D of the Nicotinic Acetylcholine Receptor Agonist Binding Site

Shimomura¹,

Yokota²,

Ihara³

et al. 2006

Mol Pharmacol

121

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The insecticide imidacloprid and structurally related neonicotinoids act selectively on insect nicotinic acetylcholine receptors (nAChRs). To investigate the mechanism of neonicotinoid selectivity, we have examined the effects of mutations to basic amino acid residues in loop D of the nAChR acetylcholine (ACh) binding site on the interactions with imidacloprid. The receptors investigated are the recombinant chicken ␣4␤2 nAChR and Drosophila melanogaster D␣2/chicken ␤2 hybrid nAChR expressed in Xenopus laevis oocytes. Although mutations of Thr77 in loop D of the ␤2 subunit resulted in a barely detectable effect on the imidacloprid concentration-response curve for the ␣4␤2 nAChR, T77R;E79V double mutations shifted the curve dramatically to higher affinity binding of imidacloprid. Likewise, T77K;E79R and T77N;E79R double mutations in the D␣2␤2 nAChR also resulted in a shift to a higher affinity for imidacloprid, which exceeded that observed for a single mutation of Thr77 to basic residues. By contrast, these double mutations scarcely influenced the ACh concentration-response curve, suggesting selective interactions with imidacloprid of the newly introduced basic residues. Computational, homology models of the agonist binding domain of the wild-type and mutant ␣4␤2 and D␣2␤2 nAChRs with imidacloprid bound were generated based on the crystal structures of acetylcholine binding proteins of Lymnaea stagnalis and Aplysia californica. The models indicate that the nitro group of imidacloprid interacts directly with the introduced basic residues at position 77, whereas those at position 79 either prevent or permit such interactions depending on their electrostatic properties, thereby explaining the observed functional changes resulting from site-directed mutagenesis.

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confidence: 99%

Role in the Selectivity of Neonicotinoids of Insect-Specific Basic Residues in Loop D of the Nicotinic Acetylcholine Receptor Agonist Binding Site

Shimomura¹,

Yokota²,

Ihara³

et al. 2006

Mol Pharmacol

121

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“…Despite the increasing number of ectoparasiticide products and their use, flea and ticks infestation of dogs remains common in Europe and other continents [7]. Many ectoparasiticides have been formulated for topical application (spot ons, collars) or more recently for oral administration [8] [9].…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Frontline Tri-Act® Spot on (Fipronil/Permethrin) versus Seresto® Collar (Imidacloprid/Flumethrin) against Fleas (Ctenocephalides felis) and Ticks (Rhipicephalus sanguineus) on Dogs with Simulation of Bi-Monthly Rain Exposure

Beugnet¹,

Servonnet²,

Halos³

et al. 2018

OJVM

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The objective of the study was to compare the efficacy of one topical insecticide-acaricide (Frontline Tri-Act®) and of one collar (Seresto®) against fleas (Ctenocephalides felis) and ticks (Rhipicephalus sanguineus) on dogs exposed to bi-weekly water showering. Twenty four (24) dogs were enrolled in the study. A first set of 16 dogs were acclimatised to their cages from Day 1 to 7 and a second set of 8 dogs from Day 163 to Day 169. The 24 dogs were randomly allocated to three groups (1 to 3). Dogs assigned to Group 1 were not treated and served as negative controls. Dogs assigned to Group 2 received the Seresto® collar on Day 0 and dogs in Group 3 received Frontline Tri-Act® on Days 170 and 198. The dogs were observed hourly for four hours after treatment administration for possible adverse reactions. Dogs in Groups 1 and 2 underwent water showering on Days 14, 28, 42, 56, 70, 84, 98, 112, 126, 143 and 157

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“…The cat flea, Ctenocephalides felis felis, is widely recognised as the most common ectoparasite infesting dogs and cats worldwide (Bond et al 2007;Rust 2005;Slapeta et al 2011). Aside from being a prominent cause of dermatitis and anaemia in these companion animals (reviewed by Dryden 2009), the cat flea is also a recognised vector for several disease agents, including Bartonella and Rickettsia spp.…”

Section: Introductionmentioning

confidence: 99%

“…Approaches to cat flea control have evolved considerably over time. Arguably the most significant change in the last twenty years has been a shift away from strategies that were underpinned by separate and often very frequent chemical treatment of host and environment, towards reliance upon monthly application of treatment to host only (Rust 2005). This has been achieved thanks to the advent of several highly effective insecticide classes that maintain a high degree of residual adulticidal efficacy on the host and, in many cases, possess activity against off-host life stages in the host's environment (Dryden 2009).…”

Section: Introductionmentioning

confidence: 99%

Monitoring Field Susceptibility to Imidacloprid in the Cat Flea: A World-First Initiative Twelve Years on

et al. 2013

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In 2001, an international surveillance initiative was established, utilising a validated larval development inhibition assay to track the susceptibility of cat flea isolates to imidacloprid. In 2009, an Australian node was incorporated into the programme, joining laboratories in the United States and Europe. Field isolates of Ctenocephalides felis eggs were submitted to participating laboratories and, where egg quantity and quality was sufficient, were placed in the imidacloprid discriminating dose bioassay for evaluation. Between 2002 and 2012, a total of 2,307 cat flea isolates were received across all sites; 1,685 submissions (73 %) were suitable for placement into the bioassay. In the Northern Hemisphere, isolate submission rate was influenced by season, with highest numbers submitted S48Ectopar asitEs between June and October. In Australia, pets with flea infestations could be sourced yearround, and submission rate was largely influenced by programme factors and not climate. A total of 1,367 valid assays were performed between 2002 and 2012 (assay validity data was not recorded in 2001); adult flea emergence 5 % or greater at 3 ppm imidacloprid was observed in 38 of these assays (2.8 %). For these isolates that reached the threshold for further investigation, re-conduct of the assay using either a repeat challenge dose of 3 ppm of imidacloprid or a dose response probit analysis confirmed their susceptibility to imidacloprid. From 2009 to 2012, the Australian node performed valid assays on 97 field isolates from a total of 136 submissions, with no adult emergence observed at the 3-ppm imidacloprid discriminating dose. In addition to reviewing the data generated by this twelve-year initiative, this paper discusses lessons learned from the coordination and evolution of a complex project across geographically dispersed laboratories on three continents.

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Advances in the control of (cat flea) on cats and dogs

Cited by 160 publications

References 44 publications

Role in the Selectivity of Neonicotinoids of Insect-Specific Basic Residues in Loop D of the Nicotinic Acetylcholine Receptor Agonist Binding Site

Role in the Selectivity of Neonicotinoids of Insect-Specific Basic Residues in Loop D of the Nicotinic Acetylcholine Receptor Agonist Binding Site

Comparative Efficacy of Frontline Tri-Act<sup>®</sup> Spot on (Fipronil/Permethrin) versus Seresto<sup>®</sup> Collar (Imidacloprid/Flumethrin) against Fleas (<i>Ctenocephalides felis</i>) and Ticks (<i>Rhipicephalus sanguineus</i>) on Dogs with Simulation of Bi-Monthly Rain Exposure

Monitoring Field Susceptibility to Imidacloprid in the Cat Flea: A World-First Initiative Twelve Years on

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