Advances in the interventional management of neuropathic pain

Varshney, Vishal; Osborn, Jill; Chaturvedi, Rahul; Shah, Vrajesh; Chakravarthy, Krishnan

doi:10.21037/atm-20-6190

Cited by 20 publications

(29 citation statements)

References 56 publications

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Section: Chronic Npmentioning

confidence: 99%

“…NP can be classified depending on the underlying lesion or disease [ 2 ], or according to the clinical phenotype [ 3 ]. The 11th edition of the International Classification of Diseases (ICD-11) distinguishes NPs of peripheral and central origin, consisting of nine common conditions associated with persistent or recurrent pain [ 3 , 4 ] ( Table 1 ). Chronic NP caused by a lesion or disease in the somatosensory nervous system can be spontaneous and cause an increased response to painful stimuli (hyperalgesia) or a painful response to painless stimuli (allodynia) [ 3 ].…”

Section: Chronic Npmentioning

confidence: 99%

“…The 11th edition of the International Classification of Diseases (ICD-11) distinguishes NPs of peripheral and central origin, consisting of nine common conditions associated with persistent or recurrent pain [ 3 , 4 ] ( Table 1 ). Chronic NP caused by a lesion or disease in the somatosensory nervous system can be spontaneous and cause an increased response to painful stimuli (hyperalgesia) or a painful response to painless stimuli (allodynia) [ 3 ]. The subtypes of chronic peripheral NP are the following: Trigeminal neuralgia, chronic NP after peripheral nerve injury, painful polyneuropathy, postherpetic neuralgia, and painful radiculopathy.…”

Section: Chronic Npmentioning

confidence: 99%

“…In general, chronic NP is poorly recognized, poorly diagnosed, and poorly treated. Diagnosis of chronic NP requires a medical history of lesion or disease of the nervous system and clinical examination showing negative (e.g., decreased or loss of sensation) or positive sensory signs (e.g., allodynia or hyperalgesia) with a plausible neuroanatomical distribution [ 3 ]. NP treatment is a real challenge for physicians.…”

Section: Chronic Npmentioning

confidence: 99%

“…Neuropathic pain (NP) is defined by The International Association for the Study of Pain (IASP) as pain that occurs as a direct consequence of lesion or disease affecting the somatosensory system [ 2 ]. NP makes up 20–25% of chronic pain patients, and although it may vary, due to a global dissonance of the definition of NP, a systematic epidemiological review has estimated the prevalence of NP between 3% and 17% [ 3 ]. Despite significant advances in NP treatment, safe and effective treatment options targeting NP are lacking.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain

Joshi

Kim

et al. 2021

IJMS

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Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disease mechanisms. Current pharmacological and nonpharmacological approaches can provide long-lasting pain relief to a limited percentage of patients and lack safe and effective treatment options. Therefore, scientists are focusing on the introduction of novel treatment approaches, such as stem cell therapy. A growing number of reports have highlighted the potential of stem cells for treating NP. In this review, we briefly introduce NP, current pharmacological and nonpharmacological treatments, and preclinical studies of stem cells to treat NP. In addition, we summarize stem cell mechanisms—including neuromodulation in treating NP. Literature searches were conducted using PubMed to provide an overview of the neuroprotective effects of stem cells with particular emphasis on recent translational research regarding stem cell-based treatment of NP, highlighting its potential as a novel therapeutic approach.

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Section: Chronic Npmentioning

confidence: 99%

Section: Chronic Npmentioning

confidence: 99%

Section: Chronic Npmentioning

confidence: 99%

Section: Chronic Npmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain

Joshi

Kim

et al. 2021

IJMS

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Intermolecular Dynamics and Structure in Aqueous Lidocaine Hydrochloride Solutions

et al. 2022

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We investigated the intermolecular dynamics and static structure in the aqueous solutions of lidocaine hydrochloride (LDHCl) in the concentration range of [LDHCl] = 0−2.00 M using femtosecond Raman-induced Kerr effect spectroscopy (fs-RIKES), small-and wideangle X-ray scattering (SWAXS), and dynamic light scattering (DLS). For the fs-RIKES experiments, the concentration dependence of the difference low-frequency spectra of the aqueous LDHCl solutions relative to the neat water, which was mainly due to the intermolecular vibrations, was characterized using an exponential function with a characteristic concentration of ∼1 M. For the SWAXS experiments, we observed a manifestation of an excess scattering component centered within a range of 8−10 nm −1 in the aqueous LDHCl solutions. The results of Fourier inversion and further deconvolution analyses unambiguously demonstrated that lidocaines assemble into a nanometer-sized micelle-like structure with the innermost core (∼0.3 nm) and outer shell (∼0.5 nm), respectively. The DLS experiments also found nanometer-sized aggregates and further indicated evidence of the clusters of the aggregates. The results of viscosities, densities, and surface tensions of the solutions and the quantum chemistry calculations supported the unique features of the microscopic intermolecular interaction and the micelle-like aggregation.

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The temporal and spatial signature of microglial transcriptome in neuropathic pain

Liu

Dai

et al. 2023

NeuroReport

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Microglial activation following peripheral nerve injury is crucial for neuropathic pain (NP) development; however, studies on time-specific and spatial characteristics of microglial transcriptome are scarce. Firstly, we comparatively analysed microglial transcriptome of different brain regions and multiple timepoints after nerve injury by analysing the gene expression profile of GSE180627 and GSE117320. Then, we performed a mechanical pain hypersensitivity test on 12 rat neuropathic pain models using von Frey fibres at various timepoints after nerve injury. To further explore the key gene clusters closely related to the neuropathic pain phenotype, we conducted a weighted gene co-expression network analysis (WGCNA) on the GSE60670 gene expression profile. Lastly, we performed a single-cell sequencing analysis on GSE162807 for identifying microglia subpopulations. We found that the trend of microglia's transcriptome changes after nerve injury was that mRNA expression changes mainly occur early after injury, which is also consistent with phenotypic changes (NP progression). We also revealed that in addition to spatial specificity, microglia are also temporally specific in NP progression following nerve injury. The WGCNA findings revealed that the functional analysis of the key module genes emphasized the endoplasmic reticulum's (ER's) crucial role in NP. In our single-cell sequencing analysis, microglia were clustered into 18 cell subsets, of which we identified specific subsets of two timepoints (D3/D7) post-injury. Our study further revealed the temporal and spatial gene expression specificity of microglia in neuropathic pain. These results contribute to our comprehensive understanding of the pathogenic mechanism of microglia in neuropathic pain.

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Advances in the interventional management of neuropathic pain

Cited by 20 publications

References 56 publications

Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain

Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain

Intermolecular Dynamics and Structure in Aqueous Lidocaine Hydrochloride Solutions

The temporal and spatial signature of microglial transcriptome in neuropathic pain

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