2023
DOI: 10.1002/adom.202202888
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Advances of NIR Light Responsive Materials for Diagnosis and Treatment of Brain Diseases

Abstract: Generally, brain diseases could be classified into various types. [2] The first is brain tumors, such as malignant glioblastoma, which grows invasively and destroys deep structures. The second type is brain trauma, i.e., traumatic brain injury (TBI), [3] which could cause multiple secondary injuries, including neuroinflammation, blood brain barrier (BBB) damage, and brain edema. The brain vascular diseases are an important type of brain diseases, such as strokes, which can induce a range of dysfunction due to … Show more

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Cited by 9 publications
(3 citation statements)
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“…By mimicking the rabies virus, Lee et al successfully developed unique silica-coated gold nanorods (RVG-PEG-AuNRs@SiO 2 ) that can penetrate the blood–brain barrier, advancing the diagnosis and treatment of brain diseases. 67 Following the Covid-19 outbreak, nanomaterials that mimic SARS-CoV-2 tissue tropism have also been efficiently delivered to specific tissues or cells, which can efficiently improve the accuracy of diagnosis or the potency of drugs. 68,69…”
Section: Viral Infection Mechanisms That Inspire the Design Of Nanosy...mentioning
confidence: 99%
“…By mimicking the rabies virus, Lee et al successfully developed unique silica-coated gold nanorods (RVG-PEG-AuNRs@SiO 2 ) that can penetrate the blood–brain barrier, advancing the diagnosis and treatment of brain diseases. 67 Following the Covid-19 outbreak, nanomaterials that mimic SARS-CoV-2 tissue tropism have also been efficiently delivered to specific tissues or cells, which can efficiently improve the accuracy of diagnosis or the potency of drugs. 68,69…”
Section: Viral Infection Mechanisms That Inspire the Design Of Nanosy...mentioning
confidence: 99%
“…NIR light has good biological safety and high tissue penetration, which makes it more suitable for deep tissue penetration applications. 184,185 Besides, appropriate light sources are selected according to different parts of the organism. (1) Irradiating light-responsive MNMs with NIR-I/ NIR-II wavelengths have been used to penetrate deep tissue regions for excellent disease treatment.…”
Section: Efficient Deep Tissue Penetration Of Light-driven Mnmsmentioning
confidence: 99%
“…Therefore, Scheme 1 PYT enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy organic materials are the best candidates for large-scale clinical application in the future, which has attracted more and more researchers' attention. Currently, the U.S. Food and Drug Administration (FDA) has approved indocyanine green (ICG) for clinical application, which is a typical example [15]. However, due to ICG inferior photothermal conversion efficiency and optical instability, the application of ICG is limited obviously.…”
Section: Introductionmentioning
confidence: 99%