Advancing Clinical and Translational Science

Wagner, John A.

doi:10.1111/cts.12450

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Wagner stated “Clinical and translational science holds the promise to put the patient at the top, the beginning, middle, and end of research. Translational medicine is evolving to become a paradigm of bedside‐to‐bench‐to‐bedside research, which will in turn drive a new era of medicine and therapeutics.” In the same spirit, our current work proposes alternative dosing strategies for initiation of sotalol therapy.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Pharmacology‐Driven Translational Research to Optimize Bedside Therapeutics of Sotalol Therapy

Dahmane

Tang

Gobburu

et al. 2019

Clinical Translational Sci

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Oral sotalol, used in adults for sinus rhythm control, is initiated at 80 mg b.i.d. and titrated to a maximum safe dose. The US Food and Drug Administration recommends monitoring the corrected QT interval (QTc) for at least 3 days, until steady‐state exposure of the drug is reached, before patient discharge, which can significantly impact the total cost of treatment. The objectives of this research were to design an accelerated intravenous sotalol loading and maintenance therapy that will reduce the hospital length of stay and to also evaluate the pharmacoeconomic impact in a hospital setting. Pharmacokinetic simulations of sotalol plasma concentrations vs. times profiles were performed to determine the optimal intravenous/oral transition regimen. A cost minimization analysis from the health sector perspective was conducted to assess the cost savings for these proposed accelerated regimens. For a chosen target dose of 120 mg b.i.d., two infusions of 40 mg over 1 hour and 20 mg over 0.5 hour, each followed up by an evaluation of QTc, can be administered followed immediately by the target oral maintenance dose of 120 mg at the end of the second infusion. Consequently, steady‐state exposure and, therefore, steady‐state QTc are obtained on the first day of therapy, facilitating an earlier hospital discharge. Two and 1‐day mean total cost of −$3,123 (95% confidence interval (CI), −$3,640, −$2,607) −$4,820 (95% CI, −$5,352, −$4,288) were observed for this strategy, respectively. We are proposing an intravenous to oral transition strategy for sotalol that has the potential to significantly reduce cost and increase patient convenience.

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Section: Discussionmentioning

confidence: 99%

“…Wagner states that translational medicine is bolstered by quantitative, model‐based, and mechanistic approaches. We propose to use the state‐of‐the‐art knowledge to optimize bedside therapeutics of sotalol.…”

mentioning

confidence: 99%

Clinical Pharmacology‐Driven Translational Research to Optimize Bedside Therapeutics of Sotalol Therapy

Dahmane

Tang

Gobburu

et al. 2019

Clinical Translational Sci

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“…While there is a clear need for additional training programs for researchers and reviewers, existing cultural differences need to shift to address barriers. This loop or iterative process presents inherent barriers to understanding translational fundamentals and processes (Wagner 2017), as well as different research experiences and backgrounds. These barriers stem from differences in scientific disciplines or cultures, training, or practice for basic and clinical scientists; structured interdisciplinary training and sufficient protected time for research would be a logical step toward overcoming these barriers.…”

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confidence: 99%

“…While there is a clear need for additional training programs for researchers and reviewers, existing cultural differences need to shift to address barriers. This loop or iterative process presents inherent barriers to understanding translational fundamentals and processes (Wagner 2017) This commentary discusses the ongoing challenges faced by earlycareer translational researchers when conducting oral and dental research, disseminating work, and contributing to science in general. This commentary also provides some recommendations/ initiatives that potentially address or alleviate these challenges.…”

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confidence: 99%

The Translational Science Conundrum for Junior Investigators

Calderon

Momeni

Coker

2023

JDR Clinical & Translational Research

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Translational research is the integration of 2 broad categories of biomedical science—basic science and applied science. However, in dentistry, this effort has been concentrated among a few researchers and must expand to keep pace with other disciplines. This commentary discusses the ongoing challenges faced by translational researchers (particularly early-career investigators) as they conduct oral and dental research, disseminate work, and contribute to science in general. This commentary also provides some recommendations/initiatives that could potentially address or alleviate these challenges. Knowledge Transfer Statement: The challenges and recommendations outlined in this commentary will serve as steppingstones to process the concepts of translational science, facilitate training for future scientists, and serve as an approach for the early investigators in the field of translational science.

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Acoustic Characteristics of Micro-Pressure Wave at the High Speed Railway Tunnel Exit

刘¹

2018

OJAV

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Advancing Clinical and Translational Science

Cited by 3 publications

References 5 publications

Clinical Pharmacology‐Driven Translational Research to Optimize Bedside Therapeutics of Sotalol Therapy

Clinical Pharmacology‐Driven Translational Research to Optimize Bedside Therapeutics of Sotalol Therapy

The Translational Science Conundrum for Junior Investigators

Acoustic Characteristics of Micro-Pressure Wave at the High Speed Railway Tunnel Exit

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