Advancing Integrated Research in Psychological Health and Traumatic Brain Injury: Common Data Elements

Thurmond, Veronica A.; Hicks, Ramona; Gleason, Theresa; Miller, A. Cate; Szuflita, Nicholas S.; Orman, Jean A.; Schwab, Karen

doi:10.1016/j.apmr.2010.06.034

Cited by 72 publications

(57 citation statements)

References 7 publications

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“…The recommendations presented here have resulted from a large interagency initiative to find ''an integrated approach to research in psychological health and traumatic brain injury'' (Thurmond et al, 2010). Within this initiative, four working groups on TBI addressed aspects of standardization concerning demographics and clinical assessment, biomarkers, neuroimaging, and outcome.…”

Section: Discussionmentioning

confidence: 99%

“…With these considerations in mind, an inter-agency workshop on standardization of data collection in TBI and psychological health was organized in March 2009 (Thurmond et al, 2010). General recommendations for collecting data on demographics and clinical assessment, neuroimaging studies, biomarkers, and outcomes for TBI, have previously been published (Duhaime et al, 2010;Maas et al, 2010;Manley et al, 2010;Wilde et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Standardizing Data Collection in Traumatic Brain Injury

Maas

Harrison-Felix

Menon

et al. 2011

Journal of Neurotrauma

Self Cite

149

137

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Collaboration among investigators, centers, countries, and disciplines is essential to advancing the care for traumatic brain injury (TBI). It is thus important that we ''speak the same language.'' Great variability, however, exists in data collection and coding of variables in TBI studies, confounding comparisons between and analysis across different studies. Randomized controlled trials can never address the many uncertainties concerning treatment approaches in TBI. Pooling data from different clinical studies and high-quality observational studies combined with comparative effectiveness research may provide excellent alternatives in a cost-efficient way. Standardization of data collection and coding is essential to this end. Common data elements (CDEs) are presented for demographics and clinical variables applicable across the broad spectrum of TBI. Most recommendations represent a consensus derived from clinical practice. Some recommendations concern novel approaches, for example assessment of the intensity of therapy in severely injured patients. Up to three levels of detail for coding data elements were developed: basic, intermediate, and advanced, with the greatest level of detail attained in the advanced version. More detailed codings can be collapsed into the basic version. Templates were produced to summarize coding formats, explanation of choices, and recommendations for procedures. Endorsement of the recommendations has been obtained from many authoritative organizations. The development of CDEs for TBI should be viewed as a continuing process; as more experience is gained, refinement and amendments will be required. This proposed process of standardization will facilitate comparative effectiveness research and encourage high-quality meta-analysis of individual patient data.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Standardizing Data Collection in Traumatic Brain Injury

Maas

Harrison-Felix

Menon

et al. 2011

Journal of Neurotrauma

Self Cite

149

137

View full text Add to dashboard Cite

show abstract

“…Most of these evidence-based recommendations are best applied in well-funded and well-equipped neurosurgical or neurotrauma centres [15][16][17] . The recent Benchmark Evidence from South American Trials: Treatment of Intracranial Pressure (BEST Trip) trial was based on standard recommendations for randomized clinical trials in high-income countries [18][19][20][21][22] . Results were far from expected because advanced monitoring tools used to guide treatments in high-income countries were not as successful in LMICs, and discussion within the global neurotrauma scientific community emerged after the publication of this study [23][24][25][26][27] .…”

Section: Epidemiology and Global Research In Tbimentioning

confidence: 99%

Global neurotrauma research challenges and opportunities

Rubiano

Carney

Chesnut

et al. 2015

Nature

424

277

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“…155 While significant work has been done (and is continuing) to gain consensus and recommend CDEs for outcome measures for use in clinical trials and other TBI-related research, limitations of existing outcome measures remain. 156,157 For example, the most widely used primary outcome measures in clinical trials have been the Glasgow Outcome Scale (GOS) and the GOS-Extended.…”

Section: Neuropsychological Evaluationmentioning

confidence: 99%

Therapy Development for Diffuse Axonal Injury

Smith

Hicks

Povlishock

2013

Journal of Neurotrauma

Self Cite

174

146

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Diffuse axonal injury (DAI) remains a prominent feature of human traumatic brain injury (TBI) and a major player in its subsequent morbidity. The importance of this widespread axonal damage has been confirmed by multiple approaches including routine postmortem neuropathology as well as advanced imaging, which is now capable of detecting the signatures of traumatically induced axonal injury across a spectrum of traumatically brain-injured persons. Despite the increased interest in DAI and its overall implications for brain-injured patients, many questions remain about this component of TBI and its potential therapeutic targeting. To address these deficiencies and to identify future directions needed to fill critical gaps in our understanding of this component of TBI, the National Institute of Neurological Disorders and Stroke hosted a workshop in May 2011. This workshop sought to determine what is known regarding the pathogenesis of DAI in animal models of injury as well as in the human clinical setting. The workshop also addressed new tools to aid in the identification of this axonal injury while also identifying more rational therapeutic targets linked to DAI for continued preclinical investigation and, ultimately, clinical translation. This report encapsulates the oral and written components of this workshop addressing key features regarding the pathobiology of DAI, the biomechanics implicated in its initiating pathology, and those experimental animal modeling considerations that bear relevance to the biomechanical features of human TBI. Parallel considerations of alternate forms of DAI detection including, but not limited to, advanced neuroimaging, electrophysiological, biomarker, and neurobehavioral evaluations are included, together with recommendations for how these technologies can be better used and integrated for a more comprehensive appreciation of the pathobiology of DAI and its overall structural and functional implications. Lastly, the document closes with a thorough review of the targets linked to the pathogenesis of DAI, while also presenting a detailed report of those target-based therapies that have been used, to date, with a consideration of their overall implications for future preclinical discovery and subsequent translation to the clinic. Although all participants realize that various research gaps remained in our understanding and treatment of this complex component of TBI, this workshop refines these issues providing, for the first time, a comprehensive appreciation of what has been done and what critical needs remain unfulfilled.

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Advancing Integrated Research in Psychological Health and Traumatic Brain Injury: Common Data Elements

Cited by 72 publications

References 7 publications

Standardizing Data Collection in Traumatic Brain Injury

Standardizing Data Collection in Traumatic Brain Injury

Global neurotrauma research challenges and opportunities

Therapy Development for Diffuse Axonal Injury

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