Advancing smart manufacturing in the pharmaceutical industry

Ganesh, Sudarshan; Su, Qing; Nagy, Zoltán K.; Reklaitis, Gintaras V.

doi:10.1016/b978-0-12-820028-5.00002-3

Cited by 9 publications

(3 citation statements)

References 46 publications

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“…[ 15 ] The adoption of continuous manufacturing in the solid oral dosage pharmaceutical industry, involves the systematic integration of several unit operations, process knowledge and automation tools. [ 16 ] This adoption has been driven by expectations of reduced operation and capital costs, lower material inventory, improved product quality and reduced variability within the product. SM when combined with continuous manufacturing has the potential to improve economics of the process, as well as improve the energy efficiency and sustainability aspects of manufacturing.…”

Section: Introductionmentioning

confidence: 99%

Enabling energy‐efficient manufacturing of pharmaceutical solid oral dosage forms via integrated techno‐economic analysis and advanced process modeling

Sampat

Kotamarthy

Bhalode

et al. 2022

J Adv Manuf & Process

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The global pharmaceutical industry is a trillion-dollar market. However, the pharmaceutical sector often lags in manufacturing innovation and automation which limits its potential to maximize energy efficiency. The integration of technoeconomic analysis (TEA) with advanced process models as part of an overarching smart manufacturing platform, can help industries create business models, which can be adapted for manufacturing to reduce energy consumption and operating costs while ensuring product quality which can further enable a more sustainable process operation. In this study, a rational design of experiment on three unitoperations (wet granulation, drying, and milling) was performed on a batch (case 1) and continuous (case 2) pharmaceutical process to obtain experimental data. Process models for predicting product quality and energy efficiency of each of the three-unit operations were developed. The experimental data were used to validate the models and good agreement was observed. The energy consumption of each unit operation was calculated using statistical models relating the power consumption and the process parameters. The developed process models and energy models were further integrated into a TEA framework, which quantified the energy and monetary cost of manufacturing for both batch and continuous manufacturing cases. With this integrated framework, energy costs savings of ~33% was obtained in the continuous manufacturing process (case 2) over the batch process (case 1). K E Y W O R D Sadvanced process models, energy efficiency, Industry 4.0, smart manufacturing, technoeconomic analysis Chaitanya Sampata and Lalith Kotamarthy contributed equally to this study.

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Section: Introductionmentioning

confidence: 99%

Enabling energy‐efficient manufacturing of pharmaceutical solid oral dosage forms via integrated techno‐economic analysis and advanced process modeling

Sampat

Kotamarthy

Bhalode

et al. 2022

J Adv Manuf & Process

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“…Through the analysis of the factory monitoring logic structure, the system logic framework is designed into four layers, which are acquisition control layer, data storage layer [1] , process monitoring layer and management application layer. The functions of these four layers are shown in Figure 2.…”

Section: Overall Structure Of Energy Monitoring and Analysis System D...mentioning

confidence: 99%

Design and Research of Intelligent Energy Monitoring System for Traditional Chinese Medicine Production Enterprises

Cui

2023

Proceedings of the 2nd International Conference on Public Management, Digital Economy and Internet Technology, ICPDI 2023, Sept

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Energy consumption is high in traditional Chinese medicine production enterprises. The production of traditional Chinese medicine includes the extraction of traditional Chinese medicine components and preparations. The extraction process can be divided into several unit operations, such as filtration, evaporation, crystallization, drying, etc. The preparation process can be divided into crushing, sieving, granulation, tabletting, etc. These processes require energy consumption. Energy consumption is high in traditional Chinese medicine production enterprises. The production of traditional Chinese medicine includes the extraction of traditional Chinese medicine components and preparations. The extraction process can be divided into several unit operations, such as filtration, evaporation, crystallization, drying, etc. The preparation process can be divided into crushing, sieving, granulation, tabletting, etc. These processes require energy consumption.

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“…Digitalization can be as basic as replacing a paper book with a tablet at a visual inspection workstation. Instead of documenting their inspection results in a paper book, employees would use the tablet to enter them immediately into the enterprise resource planning system ( Ganesh et al, 2020 ). It could also be a more complicated procedure, such as digitally developing formerly paper-based operations into the new software.…”

Section: The Digitization Process In Contract Development Manufacturing Organizations (Cdmo)mentioning

confidence: 99%

Digitalization in pharmaceutical industry: What to focus on under the digital implementation process?

Hole

Hole²,

McFalone-Shaw

2021

International Journal of Pharmaceutics: X

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Digitalization of any manufacture industry is a key step in any progress of the production process. The process of digitalization includes both increased use of robotics, automatization solutions and computerization, thereby allowing to reduce costs, to improve efficiency and productivity, and to be flexible to changes. Pharmaceutical Industry (PI) has however been resistant to digitalization, mainly due to fair experience and complexity of the entailed development and manufacture processes. Nevertheless, there is a clear need to digitalize PI as the demand in both traditional and new drugs is constantly growing. Contract Development Manufacture Organizations (CDMOs) have a special digitalizing challenge. Digitalization of PI, and CDMO precisely, should be tightly related to the main aspects of Good Manufacture Practice (GMP), and, to succeed in PI digitalizing requires constant focus on GMP. Close collaboration with constantly changing stakeholders is another important factor which should be in focus during digitalization of CDMO. This paper represents an overview over the main aspects of CDMO digitalization and discusses both the opportunities and challenges of the process, focusing on the practical solutions for successive digital implementation.

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Advancing smart manufacturing in the pharmaceutical industry

Cited by 9 publications

References 46 publications

Enabling energy‐efficient manufacturing of pharmaceutical solid oral dosage forms via integrated techno‐economic analysis and advanced process modeling

Enabling energy‐efficient manufacturing of pharmaceutical solid oral dosage forms via integrated techno‐economic analysis and advanced process modeling

Design and Research of Intelligent Energy Monitoring System for Traditional Chinese Medicine Production Enterprises

Digitalization in pharmaceutical industry: What to focus on under the digital implementation process?

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