Adverse allergic reactions to linear ionic gadolinium-based contrast agents: experience with 194, 400 injections

Aran, Shima; Shaqdan, Khalid W.; Abujudeh, Hani H.

doi:10.1016/j.crad.2014.12.011

Cited by 42 publications

(44 citation statements)

References 21 publications

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“…Contrast reactions are an important source of morbidity and mortality in diagnostic imaging. Although adverse reactions to gadolinium‐based MRI contrast agents occur at a lower frequency than iodinated computed tomography (CT)‐based contrast agents, the adverse reaction rate after an injection of 0.1 or 0.2 mmol/kg of gadolinium chelate is nonetheless reported to be in the range of 0.07–2.4% . The majority of gadolinium‐based contrast reactions are mild and include coldness at the site of injection, nausea, headache, warmth, pain, paresthesias, dizziness, and itching .…”

Section: Discussionmentioning

confidence: 99%

Rates of safety incident reporting in MRI in a large academic medical center

Mansouri

Aran

Harvey

et al. 2015

J. Magn. Reson. Imaging

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Section: Discussionmentioning

confidence: 99%

Rates of safety incident reporting in MRI in a large academic medical center

Mansouri

Aran

Harvey

et al. 2015

J. Magn. Reson. Imaging

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“…Owing to this property, Gd-EOB-DTPA has been thought to be superior to the conventional extracellular Gd-based contrast agents, especially in the early detection of focal liver lesions (FLLs) (11)(12)(13). However, despite the advantages of HBP imaging in Gd-EOB-DTPA-enhanced MR, arterial phase enhancement remains critical for the detection and characterization of FLLs (14). In previous study, it has been reported that transient severe motion (TSM) often occurred after administration of Gd-EOB-DTPA (15).…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism of such phenomena still remains unclear, and some authors have attributed its severity to Gd-EOB-DTPA-related dose-toxicity (17,18). In order to minimize the issue related TSM, a body-weight calibrated dose and a slower injection rate of contrast has been adopted in previous studies (14,17). Since TSM may have a serious effect on image quality during the arterial phase, and affect diagnostic accuracy of liver disease, it is crucial to provide optimal arterial phase imaging.…”

Section: Introductionmentioning

confidence: 99%

Transient severe motion during arterial phase in patients with Gadoxetic acid administration: Can a five hepatic arterial subphases technique mitigate the artifact?

Xiao

Liu

et al. 2018

Exp Ther Med

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Abstract. Gadoxetic acid (Gd-EOB-DTPA) is a hepatocyte-specific magnetic resonance (MR) contrast agent, which has been increasingly used in recent years. However, it has been reported that Gd-EOB-DTPA related transient severe motion (TSM) is sometimes observed during the hepatic arterial phase of MR imaging, which may influence image quality. Since the hepatic arterial phase of contrast enhancement is used for the diagnosis of hepatocellular carcinoma, it is crucial to obtain a decent arterial phase imaging. The present study analyzed motion in patients receiving Gd-EOB-DTPA, comparing a single arterial phase acquisition to a five arterial phase acquisition to determine whether the multiphase acquisition was able to alleviate the TSM-related hepatic arterial MR imaging artifact. It was demonstrated that the single-phase acquisition failed to provide adequate diagnostic image quality in patients with TSM, whereas the multiphase arterial acquisition provided acceptable image quality in 20/22 (90.9%) patients with TSM. In conclusion, the results of the present study demonstrated that multiphase arterial acquisition is superior to single-phase arterial acquisition, mitigating arterial MR imaging artifacts caused by TSM after the administration of Gd-EOB-DTPA.

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“…A taxa de reações adversas foi maior em mulheres se comparado aos homens, sendo a maioria das reações classificadas como leves. 34 Em contrapartida, um estudo que avaliou 105.607 injeções de contrastes a base de gadolínio não encontrou associação entre o sexo feminino e a ocorrência de reações alérgicas, sendo que em ambos os sexos, a maioria das reações foram classificadas como leves. 35 A tabela 4 mostra os principais efeitos adversos com o uso do Gd.…”

Section: *Pacientes Ou Aplicações Do Contrasteunclassified