Adverse effects associated with the use of nonsteroidal antiinflammatory drugs: An overview

Derle, Dilip; Gujar, Kishore N.; Sagar, Banode

doi:10.4103/0250-474x.27809

Cited by 29 publications

(22 citation statements)

References 26 publications

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“…The use of NSAIDs is the second most common cause of ulcers and the rate of NSAID-caused ulcers is increasing (Ibrahim et al 2007;Hawkey (1990); Derle et al 2006). Famotidine is H 2 -receptor antagonist widely prescribed in the gastric ulcers, duodenal ulcers, Zollinger-Ellison syndrome and gastro-esophageal reflux disease.…”

Section: Introductionmentioning

confidence: 99%

Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment

Patel

Patel²

2013

Braz. arch. biol. technol.

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Section: Introductionmentioning

confidence: 99%

Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment

Patel

Patel²

2013

Braz. arch. biol. technol.

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“…Among the mediators that regulate the events of inflammation, vasoactive amines, lipid-derived eicosanoids, cytokines, chemokines and adhesion molecules have been highlighted (Silva, 2015). On the other hand, the inflammatory pain has been treated with non-steroidal anti-inflammatory agents, but present high prevalence among adverse reactions to drugs (Derle et al, 2006). However, natural products, as flavonoids, have been investigated for their mechanisms against painful, inflammatory and oxidative processes (Agrawal, 2011;Iwalewa et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological potential of Palicourea rigida kunth: A possible participation of flavonoid compounds

Moraes¹,

Santos²,

Fabri³

et al. 2017

J. Med. Plants Res.

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Palicourea rigida Kunth (Rubiaceae), also called "bate-caixa" or "douradão", has been used as antihypertensive, antiulcerogenic, anti-inflammatory and analgesic by traditional communities. Pharmacological potential of the ethanol extract from P. rigida (EEPR) and two quercetin derivatives were investigated. Using the high performance liquid chromatography (HPLC) assay, EEPR was analyzed. Phenolic contents (total phenolic and flavonoids) were quantified by spectrophotometric methods. 2,2-diphenyl-1-pycrilhydrazil (DPPH), iron reducing power and β-carotene/linoleic acid bleaching tests were applied to estimate the antoxidant capacity of EEPR. Nociception (acetic acidinduced writhing, formalin and hot plate) and inflammation (carrageenan-induced paw edema and pleurisy) assays were performed. Molecular docking was used to measure the interactions' profiles of ligands (rutin and quercetin) and cyclooxigenases (COX-1 and COX-2). HPLC analysis identified rutin and quercetin derivatives. Expressive levels of total phenolic and flavonoids and a promising antioxidant effect were measured. EEPR, rutin and quercetin reduced the abdominal contortions. EEPR was effective against both phases of formalin, while rutin and quercetin inhibited the second phase. The latency time on hot plate significantly increased after treatment with EEPR. Inflammatory parameters (paw edema, exudate volume and leukocyte infiltrate) were diminished by EEPR, rutin and quercetin. The molecular docking showed that rutin and quercetin are capable of complexing with COX-1 and COX-2 favorably through physical-chemical interactions. The results suggest that EEPR showed a relevant pharmacological potential, which may be related to action of rutin and quercetin derivatives.Key words: Palicourea rigida, rutin, quercetin, antioxidant, antinociception, inflammation. INTRODUCTIONIn the body, the imbalance between oxidant/antioxidant in favor of the oxidation promotes the oxidative stress that causes proteins, lipids and DNA damages, as well as induces a variety of cellular responses through the generation of reactive oxygen species (ROS) that may be originated from cellular metabolism or environmental sources (Nita and Grzybowski, 2016). ROS have become a concern among researchers because they have been associated with a significant number of diseases involving inflammatory and painful processes that affect humans and animals. In inflammation, for example, ROS cause vascular damage which allows the permeability of macromolecules and inflammatory cells from the blood to tissue (Mittal et al., 2014). This permeability is controlled by vasoactive and chemotactic mediators, which make the inflammatory process active, including the pain (Silva, 2015). Among the mediators that regulate the events of inflammation, vasoactive amines, lipid-derived eicosanoids, cytokines, chemokines and adhesion molecules have been highlighted (Silva, 2015). On the other hand, the inflammatory pain has been treated with non-steroidal anti-inflammatory agents, but present high prevalenc...

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“…The drugs used for adulteration include (1) steroids and non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of rheumatoid arthritis, allergy and asthma; [1,2,4 -29] (2) PDE-5 inhibitors for sexual dysfunction; [27,30 -35] (3) sibutramine as anorectic; [36 -38] and (4) sulfonylureas (chlorpropamide, tolbutamide and glibenclamide) in antidiabetic formulations. [41,42] Adulteration of AHPs with steroids and NSAIDs has been reported mostly from China, Singapore, Pakistan, South Africa and India. [2,4,27] The most commonly found steroidal adulterants include dexamethasone, hydrocortisone, prednisolone, betamethasone, cortisone and triamcinolone and the NSAIDs used include diclofenac, mefenamic acid, indomethacin, paracetamol, phenacetin and phenylbutazone.…”

Section: Introductionmentioning

confidence: 99%

“…[40] On the other hand, adverse reactions such as dyspepsia, nausea, vomiting, gastric damage with risk of haemorrhage, skin reactions, reversible renal insufficiency, nephropathy (mainly with paracetamol) and bone marrow depression are the risk factors associated with the use of NSAIDs. [41,42] Adulteration of AHPs with steroids and NSAIDs has been reported mostly from China, Singapore, Pakistan, South Africa and India. [2,3,5,7 -10,12,14 -16,18,19,23,25 -29] The methods used for detection of adulteration have been based on medical symptoms or analytical approaches such as UV colorimetry, TLC, HPLC and LC-MS. Adulteration of animal food products and environmental water samples with steroids and NSAIDs has been reviewed.…”

Section: Introductionmentioning

confidence: 99%

Detection and characterization of synthetic steroidal and non‐steroidal anti‐inflammatory drugs in Indian ayurvedic/herbal products using LC‐MS/TOF

Savaliya

Prasad

Raijada

et al. 2009

Drug Testing and Analysis

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It is claimed that ayurvedic/herbal healthcare products (AHPs) are safe because of their natural origin. However, several reports exist of adulteration of AHPs with synthetic drugs. In this study, a generalized strategy was developed using LC-MS/TOF for the detection and verification of steroidal and anti-inflammatory drugs in 58 AHPs collected from various parts of India. The strategy involved recording of mass spectral information for standard drugs-including ionization mode (ESI/APCI - ve or + ve), mass spectrum, accurate mass, identification of qualifier fragments (two), extracted ion chromatograms (EICs), isotopic pattern and determination of UV max (nm)-through UV-PDA studies. Adulteration was then detected in AHPs primarily through comparison of EICs at accurate m/z for molecular ion peaks and R(T) matching with the standard. It was confirmed by spiking with the standards, and matching mass spectrum, accurate mass, R(T) of qualifier fragments, isotopic pattern and UV spectrum of the standards with the adulterant peaks in AHPs. Dexamethasone and diclofenac were detected as adulterants in ten AHPs whereas one AHP tested positive for piroxicam and another for dexamethasone. All the adulterated products were sold by the healthcare practitioners, while no product marketed by manufacturers or chemist shops had this problem. The study showed that LC-MS/TOF-based screening could be used as a rapid approach to monitor adulteration of steroids and anti-inflammatory drugs in AHPs.

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Adverse effects associated with the use of nonsteroidal antiinflammatory drugs: An overview

Cited by 29 publications

References 26 publications

Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment

Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment

Pharmacological potential of Palicourea rigida kunth: A possible participation of flavonoid compounds

Detection and characterization of synthetic steroidal and non‐steroidal anti‐inflammatory drugs in Indian ayurvedic/herbal products using LC‐MS/TOF

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