Adverse effects of the SSRI antidepressant sertraline on early life stages of marine invertebrates

Estévez-Calvar, Noelia; Canesi, Laura; Montagna, Michele K.; Faimali, Marco; Piazza, Veronica; Garaventa, Francesca

doi:10.1016/j.marenvres.2016.05.021

Cited by 37 publications

(14 citation statements)

References 87 publications

(116 reference statements)

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“…was ranged between 0.067 to up to 1 mg.L -1 (Di Poi et al 2014). In Mytilus galloprovincialis embryotoxicity test, the EC 50 -value was 0.21 μg.L -1 for sertraline (Estévez-Calvar et al 2016). Aguirre-Martínez et al (2015) also showed that acute toxicity of the pharmaceuticals ibuprofen, carbamazepine, novobiocin and caffeine, was in the order of mg.L -1 for bacteria bioluminescence, microalgae growth inhibition and urchin fertilization.…”

Section: Acute Effects Of Pharmaceuticalsmentioning

confidence: 95%

Toxicity assessment of five emerging pollutants, alone and in binary or ternary mixtures, towards three aquatic organisms

Poi

Costil

Bouchart³

et al. 2017

Environ Sci Pollut Res

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Despite a growing scientific attention on ecological impact of emerging pollutants (EPs) such as pharmaceuticals, personal care products, and pesticides, knowledge gaps remain regarding mixture toxicity and effects on aquatic organisms. Several EPs were screened in seawater (Normandy, France), and the ecotoxicity of five compounds, chosen on their occurrence in ecosystems and use worldwide, was assessed and were the biocides methylparaben (MP) and triclosan (TCS), a pesticide degradation product (AMPA), and the pharmaceuticals venlafaxine (VEN) and carbamazepine (CBZ). The acute or sub-chronic toxicity, alone or in binary/ternary mixtures of three of them (CBZ, AMPA, and MP), was assessed on one marine and two freshwater organisms: Crassostrea gigas, Pseudokirchneriella subcapitata, and Daphnia magna. TCS and AMPA were, respectively, the most (EC < 1 mg L) and the least (EC > 50 mg L) toxic chemicals for the four endpoints (algal growth inhibition, daphnia immobilization, oyster embryotoxicity, and metamorphosis). The anxiolytic VEN (EC < 1 mg L) was particularly toxic to oyster larvae showing sensitivity difference between freshwater and marine organisms. If all the mixtures appeared to be in the same range of toxicity, the joint-toxic effects mainly led to synergistic or antagonistic interactions compared to single-compound toxicity. The data also highlighted species-dependent differing models of toxicity and underscored the need for an awareness of cocktail effects for better ecological risk assessment.

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Section: Acute Effects Of Pharmaceuticalsmentioning

confidence: 95%

Toxicity assessment of five emerging pollutants, alone and in binary or ternary mixtures, towards three aquatic organisms

Poi

Costil

Bouchart³

et al. 2017

Environ Sci Pollut Res

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“…Some invertebrates such as snails and shrimps have been selected to monitor PPCPs in the aquatic ecosystem . A number of studies report the toxicological impacts of PPCPs such as fluoxetine, citalopram, cetirizine, sertraline, diclofenac, propranolol, simvastatin, carbamazepine, and triclosan on invertebrates such as freshwater and Mediterranean mussels, sea urchin, Ephemeroptera, Baetis sp., Decapoda, and M. lanchesteri . While pharmaceuticals such as fluoxetine and clofibric acid can affect the development of some crustaceans, others (e.g.…”

Section: Introductionmentioning

confidence: 99%

Determination of selected emerging contaminants in freshwater invertebrates using a universal extraction technique and liquid chromatography accurate mass spectrometry

Althakafy

Kulsing

Grace

et al. 2018

J of Separation Science

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A simple sample preparation method based on a modified liquid-phase extraction approach to extract selected pharmaceuticals and personal care products from freshwater organisms is described. Extracted samples were analysed using liquid chromatography with Q-Exactive plus hybrid quadrupole Orbitrap mass spectrometry, using 2.6 μm C18 media. A 0.1% v/v acetic acid/acetonitrile mobile phase was applied over a 20 min gradient. Method detection limits in full scan mode were ca. 0.04-2.38 ng of analyte per g of sample. Linearity ranged from 0.9750 to 0.9996 over the calibration range of 0.01-100 μg/L; MS mass accuracy was <2 ppm for most analytes. This method was applied to quantify six pharmaceuticals and personal care products in seven invertebrate samples. For tandem mass spectrometry analysis, selection of precursor ions was performed for each pharmaceutical, with Mass Frontier software illustrating the fragmentation mechanism. Effects of collision energy on intensities of ions was further investigated. The tandem mass spectrometry condition resulting in the highest signal of respective selected product ion was selected to confirm each pharmaceutical, which was initially observed in the full scan mode. Results indicate that pharmaceuticals and personal care products found to be present in water-ways, may be incorporated into organisms that live in the environment of affected water streams.

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“…In contrast, several potential EDCs and NEDs have been shown to affect early larval development (48 h) in the mussel M. galloprovincialis at environmental concentrations (102)(103)(104). With regards to the possible molecular mechanisms involved, it was demonstrated that both the natural estrogen 17b-estradiol and the xenoestrogen bisphenol A (BPA) modulated the transcriptional profiles of different genes, in particular of those involved in shell formation and neuroendocrine signalling, including the 5-HTR1 (105).…”

Section: The Serotonergic System Of Early Bivalve Larvae As a Target ...mentioning

confidence: 99%

Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption

et al. 2022

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Contaminants of Emerging Concerns (CECs) are defined as chemicals not commonly monitored in aquatic ecosystems, but with the potential to cause adverse effects on biota. CECs include Endocrine Disrupting Chemicals (EDCs) and Neuro-Endocrine disruptors (NEDs) of vertebrates. However, most invertebrates only rely on neuroendocrine systems to maintain homeostatic processes. Although conserved neuroendocrine components have been characterized in ecologically relevant groups, limited knowledge on invertebrate neuroendocrinology makes it difficult to define EDCs and NEDs in most species. The monoamine serotonin (5-hydroxytryptamine, 5-HT) acts both as a neurotransmitter and as a peripheral hormone in mammals. In molluscs, 5-HT is involved in multiple physiological roles and molecular components of the serotonergic system have been identified. This review is focused on the effects of CECs on the serotonergic system of bivalve molluscs. Bivalves are widespread in all aquatic environments, estuarine and coastal areas in particular, where they are exposed to a variety of chemicals. In bivalves, 5-HT is involved in gametogenesis and spawning, oocyte maturation and sperm motility, regulates heart function, gill ciliary beating, mantle/siphon function, the ‘‘catch’’ state of smooth muscle and immune responses. Components of 5-HT transduction (receptors and signaling pathways) are being identified in several bivalve species. Different CECs have been shown to affect bivalve serotonergic system. This particularly applies to antidepressants, among the most commonly detected human pharmaceuticals in the aquatic environment. In particular, selective serotonin reuptake inhibitors (SSRIs) are frequently detected in seawater and in bivalve tissues. Information available on the effects and mechanisms of action of SSRIs on the serotonergic system of adult bivalves is summarized. Data are also reported on the effects of CECs on development of neuroendocrine pathways of early larval stages, in particular on the effects of model EDCs in the marine mussel Mytilus galloprovincialis. Overall, available data point at the serotonergic system as a sensitive target for neuroendocrine disruption in bivalves. The results contribute drawing Adverse Outcome Pathways (AOPs) for model EDCs and SSRIs in larvae and adults. However, basic research on neuroendocrine signaling is still needed to evaluate the potential impact of neuroendocrine disruptors in key invertebrate groups of aquatic ecosystems.

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Adverse effects of the SSRI antidepressant sertraline on early life stages of marine invertebrates

Cited by 37 publications

References 87 publications

Toxicity assessment of five emerging pollutants, alone and in binary or ternary mixtures, towards three aquatic organisms

Toxicity assessment of five emerging pollutants, alone and in binary or ternary mixtures, towards three aquatic organisms

Determination of selected emerging contaminants in freshwater invertebrates using a universal extraction technique and liquid chromatography accurate mass spectrometry

Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption

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