Adverse histological features in malignant colorectal polyps: a contemporary series of 239 cases

Abstract

Surgical resection should be recommended if ≥2 of these adverse histological features are present and may be warranted if one feature is present. A positive margin may require additional local resection but not necessarily surgery if no other adverse factors are present.

Protein kinase C zeta suppresses low‐ or high‐grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring

“…These phenomena led to cribriform morphology (CM) over longer‐term culture intervals of up to 12 days . While CM is regarded as a marker of malignant transformation in human colon , this study shows early features of this morphology in normal intestinal organoids when the ezrin/NHERF1 interaction was disrupted. Hence, these data suggest that cribriform morphogenesis is a consequence of bipolar spindle misorientation but is not necessarily restricted to malignant cells.…”

Introduction of a colorectal cancer screening programme: results from a single‐centre study

“…Interestingly, according to a T1 study of 140 surgical resection specimens, a positive margin was not associated with nodal metastasis. Also, none of the malignant polyps with carcinoma present between 0.1 and 1 mm from the margin showed residual carcinoma in these 140 surgical specimens [33]. Not surprisingly, pooled data analysis of 1900 patients with malignant polyps showed that positivity of the resection margin was significantly predictive of the presence of residual disease (OR 22; 95% CI 10.3-46.6, P < 0.0001) [34].…”

Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Multidisciplinary Management

“…With no further treatment, the risks are of luminal recurrence and progression of involved undetected mesorectal lymph nodes. Current guidelines consider carcinoma within 1 mm of the resection margin as being involved but recent evidence suggests that the risk of recurrence is highest only when tumour is present at the resection margin or within diathermized tissue (Brown et al ., ). Risk factors for lymph node involvement include extent of submucosal invasion, intramural lymphovascular invasion (LVI) and poor differentiation.…”