Adverse outcome pathway from activation of the AhR to breast cancer-related death

Benoit, Louise; Jornod, Florence; Zgheib, Elias; Tomkiewicz, Céline; Koual, Meriem; Coustillet, Thibaut; Barouki, Robert; Audouze, Karine; Vinken, Mathieu; Coumoul, Xavier

doi:10.1016/j.envint.2022.107323

“…Unfortunately, this issue cannot be alleviated with larger sample size (Agier et al, 2016), but eventually expert toxicological knowledge can be used to inform the congeners selection. Novel statistical methods incorporating that a priori toxicological information in the model (McGee et al, 2022), will be of high utility to integrate the consolidated AOP framework information of breast cancer metastasis (Benoit et al, 2022), in multipollutant analysis. In addition, other multipollutant models are currently available including extending WQS in a Bayesian framework (Colicino et al, 2020) or overcoming the assumption of directional homogeneity through quantile g-computation and outperforming WQS in some scenarios (Keil et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Impact of mixtures of persistent organic pollutants on breast cancer aggressiveness

Benoit¹

2023

Gynécologie Obstétrique Fertilité & Sénologie

0

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“…Unfortunately, this issue cannot be alleviated with larger sample size (Agier et al, 2016), but eventually expert toxicological knowledge can be used to inform the congeners selection. Novel statistical methods incorporating that a priori toxicological information in the model (McGee et al, 2022), will be of high utility to integrate the consolidated AOP framework information of breast cancer metastasis (Benoit et al, 2022), in multipollutant analysis. In addition, other multipollutant models are currently available including extending WQS in a Bayesian framework (Colicino et al, 2020) or overcoming the assumption of directional homogeneity through quantile g-computation and outperforming WQS in some scenarios (Keil et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Impact of mixtures of persistent organic pollutants on breast cancer aggressiveness

Benoit

¹

,

Koual

²

,

Tomkiewicz

³

et al. 2022

Environment International

Self Cite

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“…In another example, Nymark et al [76] proposed a AOP for lung cancer based on eighteen standardised tests especially developed for the risk assessment of nanomaterials. In addition, Benoit et al [77] proposed an AOP for breast cancer (i.e., the AO in the case) whose MIE is the activation of the AhR (aryl hydrocarbon receptor), a pivotal molecule in exposure to many carcinogenic compounds, including PAHs. An important advantage of finding AOPs is that they may circumvent the lack of a comprehensive view of an organisms' exposome for the purpose of risk assessment.…”

Section: Novel Approaches To Mechanism and Causation: Cancer And The ...mentioning

confidence: 99%

After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?

Vitorino

¹

,

Costa

²

2023

IJERPH

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Cancer is one of the longest-known human diseases, yet only in recent times have we begun to perceive that the percentage of neoplasms caused by environmental factors, lifestyle and chemicals, is likely underestimated. The first medical reports associating cancer with pollutants like tars appeared by the early 20th century, but despite initial evidence relating oncogenesis and chromosomal alterations, only after the structure of DNA had been elucidated in the 1950s have genetic disorders been fully perceived as cause. This led to a growing interest in genotoxic and mutagenic pollutants. Even though we are now familiar with a range of environmental carcinogens spanning between aromatic hydrocarbons and asbestos to radionuclides and forms of carbon nanomaterials, establishing causal networks between pollutants and cancer remains cumbersome. In most part, this is due to the complexity of toxicant matrices, unknown modes-of-action of chemicals or their mixtures, the widening array of novel pollutants plus difficulties in subtracting background effects from true aetiology of disease. Recent advances in analytical chemistry, high-throughput toxicology, next-generation sequencing, computational biology and databases that allocate whole normal and cancer genomes, all indicate that we are on the verge of a new age of research into mechanistic ‘oncotoxicology’, but how can it impact risk assessment and prevention?

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Adverse outcome pathway from activation of the AhR to breast cancer-related death

Cited by 34 publications

References 123 publications

Impact of mixtures of persistent organic pollutants on breast cancer aggressiveness

Impact of mixtures of persistent organic pollutants on breast cancer aggressiveness

Impact of mixtures of persistent organic pollutants on breast cancer aggressiveness

After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?

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